Vitamin K 1 (Phylloquinone)

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287 relevant articles (21 outcomes, 21 trials/studies) found for this Drug

Description: A family of phylloquinones that contains a ring of 2-methyl-1,4-naphthoquinone and an isoprenoid side chain. Members of this group of vitamin K 1 have only one double bond on the proximal isoprene unit. Rich sources of vitamin K 1 include green plants, algae, and photosynthetic bacteria. Vitamin K1 has antihemorrhagic and prothrombogenic activity.

Also Known As:

Phylloquinone; Phytomenadione; Aquamephyton; Vitamin K1; Konakion; Phyllohydroquinone; Phytonadione; 1,4-Naphthalenedione, 2-methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-, (R-(R*,R*-(E)))-

Relationship Network

Drug Context: Research Results

Organic Chemicals: 42

Hydrocarbons: 363

Experts

1.	Tirapelli, Carlos R: 2 articles (12/2002 - 09/2002)
2.	Mingatto, Fábio E: 2 articles (12/2002 - 09/2002)
3.	Gundberg, Caren: 1 article (09/2008)
4.	Grey, Vijay Laxmi: 1 article (09/2008)
5.	Lands, Larry C: 1 article (09/2008)
6.	Drury, Donna: 1 article (09/2008)
7.	Ferland, Guylaine: 1 article (09/2008)
8.	Macdonald, Helen M: 1 article (05/2008)
9.	McGuigan, Fiona E: 1 article (05/2008)
10.	Lanham-New, Susan A: 1 article (05/2008)

Related Diseases

1.	Vitamin K Deficiency 10/23/1993 - "A single administration of 1 mg vitamin K1 orally or intramuscularly may not afford complete protection against late vitamin K deficiency in healthy breastfed infants. " 08/01/1993 - "In conclusion, weekly administration of vitamin K1 1 mg offers complete protection against vitamin K deficiency and does not result in an accumulation of vitamin K1 in the blood." 12/01/2009 - "The high proportion of false positive results suggest that poor assay specificity at low phylloquinone concentrations is a common problem, which in the clinical setting could lead to underreporting of vitamin K deficiency." 10/23/1993 - "A regimen of 1 mg per week or 25 micrograms vitamin K1 per day proved to be effective in prevention of vitamin K deficiency and the latter is recommended for breastfed infants during the first three months of life." 12/01/2005 - "CONCLUSION: In preterm infants born at <32 wk gestation who received > or = 0.2 mg vitamin K(1) after delivery, a prolonged PT in the first month of life is unlikely to be due to vitamin K deficiency." Order ALL the reference details at left...
2.	Hemorrhage 12/01/1989 - "Studies of a larger number of patients are necessary before it can be established that maternal antenatal administration of vitamin K1 results in improvement of coagulation and the prevention of intraventricular hemorrhage in premature infants." 06/01/2007 - "Initial prothrombin time and activated partial thromboplastin time were both greater than 110 seconds and the patient suffered severe gastric and pulmonary hemorrhage requiring fresh frozen plasma transfusion and parenteral phytonadione administration (up to 100 mg per day). " 12/01/2006 - "To protect against late vitamin K1 deficiency bleeding, breastfed preterm infants given a 0.2-mg dose of prophylaxis should receive additional supplementation when feeding has been established." 06/01/2006 - "RESULTS: No randomized, controlled trial testing prenatal vitamin K1 administration for reducing the incidence or severity of neonatal hemorrhage was identified. " 06/01/2006 - "Prenatal vitamin K1 administration in epileptic women to prevent neonatal hemorrhage: is it effective?" Order ALL the reference details at left...
3.	Hypoprothrombinemias (Prothrombin Deficiency) 01/01/1959 - "Efficacy of water-soluble derivatives of vitamin K1 in counteracting drug-induced hypoprothrombinemia." 11/01/1959 - "[A new study on the therapeutic action of vitamin K1 on hypoprothrombinemia in the premature infant.]" 07/01/1963 - "Drug-induced hypoprothrombinemia countered with phytonadione." 07/26/1959 - "[Vitamin K1 and hypoprothrombinemias in hepatic diseases.]" 07/01/1959 - "Oral phytonadione in neonatal hypoprothrombinemia." Order ALL the reference details at left...
4.	Osteoporosis 02/01/2008 - "Both vitamin K1 and K2 have been shown to exert protective effects against osteoporosis. " 09/01/2006 - "Both vitamin K(1) and K(2) have been shown to exert protective effects against osteoporosis. " 06/01/1985 - "Electrochemical detection of depressed circulating levels of vitamin K1 in osteoporosis." 08/01/2005 - "CONCLUSION: Phytonadione and menaquinone may be effective for the prevention and treatment of osteoporosis and arterial calcification." 03/01/2005 - "Vitamin K2 exerts a more powerful influence on bone than vitamin K1, and should be considered for prevention or treatment in those conditions known to contribute to osteoporosis." Order ALL the reference details at left...
5.	Liver Diseases (Liver Disease) 02/01/1995 - "Adverse effects are seen not only in patients with liver-function disturbances but also in patients without liver diseases, and occur mostly after intramuscular or subcutaneous administration of vitamin K1, independent of the total dose. " 03/12/1959 - "[Indications for vitamin K1 in liver disease.]" 01/01/1958 - "[Effect of synthetic vitamin K1 in liver diseases in small children.]" 02/01/1993 - "Our findings support the observation that liver disease is not a necessary condition for the occurrence of vitamin K1 hypersensitivity." 12/01/2000 - "CONCLUSION: Oral menadiol appears to be an effective alternative to intravenous phytomenadione in the correction of coagulopathies associated with obstructive liver disease. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Vitamin K 1 (Phylloquinone)
2.	Vitamin K
3.	Warfarin (Coumadin)
4.	Vitamin K 2 (Vitamin K2)
5.	Blood Coagulation Factors (Coagulation Factor)
6.	Prothrombin (Factor II)
7.	Dicumarol (Dicoumarol)
8.	Vitamin K 3 (Menadione)
9.	menadiol
10.	Acetaminophen (Paracetamol)

Related Therapies and Procedures

1.	Injections
2.	Intravenous Injections
3.	Renal Dialysis (Hemodialysis)
4.	Hip Replacement Arthroplasty (Total Hip Replacement)
5.	Lasers (Laser)

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