Phosphorylcholine (Phosphocholine)

Calcium and magnesium salts used therapeutically in hepatobiliary dysfunction.

Also Known As:

Phosphocholine; Choline Phosphate; Chloride, Choline Phosphate; Chloride, Phosphorylcholine; Phosphate Chloride, Choline; Phosphate, Choline; Choline Chloride Dihydrogen Phosphate; Choline Phosphate Chloride; Phosphorylcholine Chloride; Ethanaminium, N,N,N-trimethyl-2-(phosphonooxy)-, chloride

Networked: 752 relevant articles (29 outcomes, 76 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Quaternary Ammonium Compounds: 136
    - Trimethyl Ammonium Compounds: 1
      - Choline: 6256
        Phosphorylcholine: 752
        erucylphosphocholine: 2372
        miltefosine: 803
        perifosine: 190
        sphingosine phosphorylcholine: 84
        tyloxapol drug combination hexadecanol dipalmitoylphosphatidylcholine: 80
        4-nitrophenylphosphorylcholine: 28
        2-methacryloyloxyethyl phosphorylcholine: 23
        oleyloxyethylphosphorylcholine: 20
        dodecylphosphocholine: 12
        tuftsin-phosphorylcholine: 10
        n-octadecylphosphocholine: 6
        poly(2-methacryloyloxyethyl-phosphorylcholine): 6
        oleylphosphocholine: 5
        phosphorylcholine-bovine serum albumin: 5
        poly(2-(methacryloyloxy)ethyl phosphorylcholine)-block-(2-(diisopropylamino)ethyl methacrylate): 5
        CLR1502: 3
        erucylphosphohomocholine ErPC3: 3
        poly(2-methacryloyloxyethyl phosphorylcholine-co-n-butyl methacrylate): 3
        1,6-bis(phosphocholine)-hexane: 2
        18-(4-iodophenyl)octadecylphosphocholine: 1
        eushearilide: 1
        hepasteril: 1
        N-decylphosphorylcholine: 1
        n-tetradecylphosphorylcholine: 1
        poly(2-methacryloyloxyethyl phosphorylcholine)-b-poly(methacrylic acid): 1
        poly(epsilon-caprolactone)-block-poly(2-(methacryloyloxy)ethyl phosphorylcholine): 1
        sn-glycerol-3-phosphocholine: 1
        (11-(((2,6-dinitro-4-trifluoromethyl)phenyl)butylamino)(undecylphospinyloxy)ethyl) N,N,N trimethylammonium
        1,2-dipalmitoyl-sn-glycero-3-thiophosphocholine
        1,2-dipentadecylmethylidenephosphatidylcholine
        1-0-hexadecyl-2-azelaoyl-sn-glycero-3-phosphocoline
        1-cyano methano phosphocholine
        1-O-phosphocholine-2-O-acetyloctadecane
        1-O-phosphocholine-2-O-methyloctadecane
        1-palmitoyl-2-azelaoyl-sn-glycero-3-phosphocholine
        1-S-phosphocholine-2-O-hexadecanoyl-1-mercapto-2-ethanol
        13-phenyltrideca-6,8,10,12-tetraenylphosphocholine
        13-phenyltrideca-8,10,12-trien-6-ynylphosphocholine
        2-(5,6-epoxyisoprostane A2)phosphorylcholine
        2-acryloyloxyethyl phosphorylcholine
        2-hexadecanoylamino-4-nitrophenylphosphorylcholine
        2-undecylphosphocholine
        3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecylphosphocholine
        4-aminophenylphosphorylcholine
        4-azophenylphosphorylcholine
        4-diazophenylphosphocholine
        4-nitrophenyl-6-(O-phosphocholine)hydroxyhexanoate
        4-nitrophenylphosphocholine
        AWD 56-02
        azido-LPC
        CA-PMB-PMA30 HFM
        cyclopentadecylpentylphosphocholine
        diphenylphosphorylcholine
        eicosanylphosphocholine
        fosfolip
        irlbacholine
        methyl phosphorylcholine
        MPCAM polymer
        N,N',N'-tri-(6-(6-O-phosphorylcoline-b-D-galactopyranosyl-(1'-6)-b - D-galactopyranosyloxy)hexyl)-1,3,5-benzenetriamide
        n-octylphosphorylcholine
        O,O-diethylphosphorylcholine iodide
        O-mannopyranosyl-1-2-mannitol-6-phosphocholine
        octadecyl-(2-(N-methylpiperidino)ethyl)phosphate
        P(MMA:MA:APC)terpolymer
        phosphocholine F8C11PC
        phosphorylhomocholine
        poly((propargyl methacrylate)-ran-(2-methacryloyloxyethyl phosphorylcholine))
        poly(2-(dimethylamino)ethyl methacrylate-b-2-methacryloyloxyethyl phosphorylcholine)
        poly(MPC-co-MA)
        stigmastanyl-phosphorylcholine
        tocopheryl-6-O-phosphorylcholine
- Onium Compounds
  - Quaternary Ammonium Compounds: 136
    - Choline: 6256
      - Phosphorylcholine: 752
        erucylphosphocholine: 2372
        miltefosine: 803
        perifosine: 190
        sphingosine phosphorylcholine: 84
        tyloxapol drug combination hexadecanol dipalmitoylphosphatidylcholine: 80
        4-nitrophenylphosphorylcholine: 28
        2-methacryloyloxyethyl phosphorylcholine: 23
        oleyloxyethylphosphorylcholine: 20
        dodecylphosphocholine: 12
        tuftsin-phosphorylcholine: 10
        n-octadecylphosphocholine: 6
        poly(2-methacryloyloxyethyl-phosphorylcholine): 6
        oleylphosphocholine: 5
        phosphorylcholine-bovine serum albumin: 5
        poly(2-(methacryloyloxy)ethyl phosphorylcholine)-block-(2-(diisopropylamino)ethyl methacrylate): 5
        CLR1502: 3
        erucylphosphohomocholine ErPC3: 3
        poly(2-methacryloyloxyethyl phosphorylcholine-co-n-butyl methacrylate): 3
        1,6-bis(phosphocholine)-hexane: 2
        18-(4-iodophenyl)octadecylphosphocholine: 1
        eushearilide: 1
        hepasteril: 1
        N-decylphosphorylcholine: 1
        n-tetradecylphosphorylcholine: 1
        poly(2-methacryloyloxyethyl phosphorylcholine)-b-poly(methacrylic acid): 1
        poly(epsilon-caprolactone)-block-poly(2-(methacryloyloxy)ethyl phosphorylcholine): 1
        sn-glycerol-3-phosphocholine: 1
        (11-(((2,6-dinitro-4-trifluoromethyl)phenyl)butylamino)(undecylphospinyloxy)ethyl) N,N,N trimethylammonium
        1,2-dipalmitoyl-sn-glycero-3-thiophosphocholine
        1,2-dipentadecylmethylidenephosphatidylcholine
        1-0-hexadecyl-2-azelaoyl-sn-glycero-3-phosphocoline
        1-cyano methano phosphocholine
        1-O-phosphocholine-2-O-acetyloctadecane
        1-O-phosphocholine-2-O-methyloctadecane
        1-palmitoyl-2-azelaoyl-sn-glycero-3-phosphocholine
        1-S-phosphocholine-2-O-hexadecanoyl-1-mercapto-2-ethanol
        13-phenyltrideca-6,8,10,12-tetraenylphosphocholine
        13-phenyltrideca-8,10,12-trien-6-ynylphosphocholine
        2-(5,6-epoxyisoprostane A2)phosphorylcholine
        2-acryloyloxyethyl phosphorylcholine
        2-hexadecanoylamino-4-nitrophenylphosphorylcholine
        2-undecylphosphocholine
        3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecylphosphocholine
        4-aminophenylphosphorylcholine
        4-azophenylphosphorylcholine
        4-diazophenylphosphocholine
        4-nitrophenyl-6-(O-phosphocholine)hydroxyhexanoate
        4-nitrophenylphosphocholine
        AWD 56-02
        azido-LPC
        CA-PMB-PMA30 HFM
        cyclopentadecylpentylphosphocholine
        diphenylphosphorylcholine
        eicosanylphosphocholine
        fosfolip
        irlbacholine
        methyl phosphorylcholine
        MPCAM polymer
        N,N',N'-tri-(6-(6-O-phosphorylcoline-b-D-galactopyranosyl-(1'-6)-b - D-galactopyranosyloxy)hexyl)-1,3,5-benzenetriamide
        n-octylphosphorylcholine
        O,O-diethylphosphorylcholine iodide
        O-mannopyranosyl-1-2-mannitol-6-phosphocholine
        octadecyl-(2-(N-methylpiperidino)ethyl)phosphate
        P(MMA:MA:APC)terpolymer
        phosphocholine F8C11PC
        phosphorylhomocholine
        poly((propargyl methacrylate)-ran-(2-methacryloyloxyethyl phosphorylcholine))
        poly(2-(dimethylamino)ethyl methacrylate-b-2-methacryloyloxyethyl phosphorylcholine)
        poly(MPC-co-MA)
        stigmastanyl-phosphorylcholine
        tocopheryl-6-O-phosphorylcholine

Experts

1.	Frostegård, Johan: 30 articles (01/2022 - 09/2006)
2.	Bhujwalla, Zaver M: 22 articles (10/2018 - 04/2003)
3.	Glunde, Kristine: 19 articles (10/2019 - 10/2003)
4.	de Faire, Ulf: 14 articles (01/2022 - 09/2006)
5.	Leach, Martin O: 11 articles (12/2017 - 09/2003)
6.	Workman, Paul: 9 articles (07/2017 - 11/2003)
7.	Harnett, William: 9 articles (11/2016 - 08/2003)
8.	Mori, Noriko: 8 articles (10/2018 - 04/2003)
9.	Harnett, Margaret M: 8 articles (11/2016 - 03/2008)
10.	Krishnamachary, Balaji: 8 articles (01/2016 - 04/2009)

Related Diseases

1.	Infections 01/01/2023 - "Taken together, we conclude that the phosphocholine cytidylyltransferase coding gene MoPCT1 plays important roles in vegetative growth, conidiation and appressorium-mediated plant infection by M. " 01/01/2023 - "Phosphocholine cytidylyltransferase MoPct1 is crucial for vegetative growth, conidiation, and appressorium-mediated plant infection by Magnaporthe oryzae." 11/24/2022 - "In addition, LC-MS analysis revealed that (1R,3R)-HPA-12 is converted to a phosphocholine-conjugated metabolite in an infection-dependent manner. " 01/01/2017 - "influenzae self-aggregation, phosphorylcholine level, C3b deposition, and airway epithelial infection patterns. " 10/01/2015 - "Using mass spectrometry and murine upper airway infection models, we demonstrated that phosphorylcholine (ChoP) moieties that are shared by PAF and the bacterial cell wall allow S. "
2.	Pneumococcal Infections 01/01/2020 - "We can conclude now that complement activation by phosphocholine-complexed CRP is indeed essential for CRP-mediated protection of mice against pneumococcal infection." 12/14/2012 - "We conclude that the phosphocholine-binding pocket on CRP is necessary for CRP-mediated initial protection of mice against lethal pneumococcal infection." 06/01/2007 - "CRP binds to phosphocholine in the Streptococcus pneumoniae cell wall and provides innate defense against pneumococcal infection. " 01/01/1991 - "Antibodies to phosphorylcholine, raised by immunization of 6-week-old mice are normally protective against pneumococcal infection. " 01/01/2017 - "In young adult BALB/c mice, antibodies to phosphorylcholine (PC) bearing the T15 (TEPC 15) idiotype confer protection against pneumococcal infections. "
3.	Neoplasms (Cancer) 07/01/2006 - "Ex vivo high-resolution magic angle spinning (HRMAS) and 1H MRS of metabolite extracts revealed a significant reduction in phosphocholine and glycerophosphocholine in biopsies of ZD6126-treated tumors, confirming in vivo tCho response. " 01/07/2010 - "Nuclear magnetic resonance (NMR)-based metabolomic studies of human tumors have identified a marked increase in the intracellular concentration of phosphocholine relative to normal tissues. " 09/01/2003 - "Several (31)P MRS studies in tumors in vivo have shown that levels of phosphocholine (PC) and other phosphomonoesters (PME) and phosphodiesters (PDE) are useful prognostic or early-response indicators. " 01/01/2020 - "The phosphorylcholine-based zwitterionic copolymer effectively extended the blood circulation time, resulting in enhanced tumor accumulation of the nanodrug. " 04/01/2018 - "Phosphocholine inhibited tumor cell invasion and migration, and promoted cell proliferation and autophagy, all in a dose-dependent manner. "
4.	Atherosclerosis 08/07/2007 - "The present study evaluated the effect of phosphorylcholine (PC) immunization on the extent of experimental atherosclerosis. " 04/01/2020 - "Targeting Phosphorylcholine in Established Atherosclerosis?" 08/07/2007 - "Phosphorylcholine-targeting immunization reduces atherosclerosis." 04/01/2020 - "The noninvasive imaging techniques represent translational tools to assess the efficacy of phosphorylcholine-targeted therapy on coronary artery function and atherosclerosis in clinical studies." 01/16/2021 - "Phosphorylcholine-Primed Dendritic Cells Aggravate the Development of Atherosclerosis in ApoE-/- Mice."
5.	Cardiovascular Diseases (Cardiovascular Disease) 09/01/2009 - "Natural antibodies against phosphorylcholine in cardiovascular disease." 01/01/2017 - "We here study antibodies against phosphorylcholine (anti-PC) which we reported to be inversely associated with atherosclerosis, cardiovascular disease (CVD), and autoimmune conditions. " 01/01/2022 - "Antibodies against phosphorylcholine (anti-PC) are implicated as protection markers in atherosclerosis, cardiovascular disease (CVD), and other chronic inflammatory conditions. " 01/01/2012 - "We have reported that anti-phosphorylcholine (anti-PC) IgM is a protection marker for human cardiovascular disease (CVD) and atherosclerosis. " 01/01/2010 - "Low level natural antibodies against phosphorylcholine: a novel risk marker and potential mechanism in atherosclerosis and cardiovascular disease."

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