Phosphorylase Kinase (Phosphorylase Kinase, Glycogen)

An enzyme that catalyzes the conversion of ATP and PHOSPHORYLASE B to ADP and PHOSPHORYLASE A.

Also Known As:

Phosphorylase Kinase, Glycogen; Glycogen Phosphorylase Kinase; Phosphorylase b Kinase; Kinase, Glycogen Phosphorylase; Kinase, Phosphorylase; Kinase, Phosphorylase b; b Kinase, Phosphorylase; ATP:phosphorylase-b phosphotransferase

Networked: 123 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Phosphotransferases: 42769
      - Phosphotransferases (Alcohol Group Acceptor)
        Protein Kinases: 9677
        Phosphorylase Kinase: 123
        Drosophila PhKgamma protein
        human PHKA2 protein
        mouse PSTK protein

Experts

1.	Vissing, J: 3 articles (01/2020 - 05/2008)
2.	Bali, Deeksha S: 3 articles (01/2019 - 03/2014)
3.	Kishnani, Priya S: 3 articles (01/2019 - 03/2014)
4.	Burwinkel, Barbara: 3 articles (06/2005 - 07/2003)
5.	Kilimann, Manfred W: 3 articles (06/2005 - 07/2003)
6.	Ørngreen, M C: 2 articles (01/2020 - 05/2008)
7.	Pendyal, Surekha: 2 articles (01/2019 - 01/2017)
8.	Weinstein, David A: 2 articles (01/2019 - 03/2014)
9.	Austin, Stephanie: 2 articles (01/2017 - 03/2014)
10.	Fredrickson, Keri: 2 articles (01/2017 - 03/2014)

Related Diseases

1.	Glycogen Storage Disease (Glycogenosis) 12/01/1982 - "Phosphorylase-b-kinase: glycogen storage disease (type 9b)--a family study." 01/01/2020 - "Analysis of the phosphorylase kinase regulatory subunit alpha 1 (PHKA1) gene revealed a pathogenic mutation (p.C1082X), indicating glycogen storage disease type Ⅸd. " 04/20/2017 - "[Glycogenosis type IX caused by a novel mutation of phosphorylase kinase α subunit: a family analysis]." 01/01/2011 - "X-linked liver glycogenosis (XLG) is caused by a mutation in the PHKA2 gene which encodes the alpha subunit of phosphorylase kinase (PHK). " 11/01/2008 - "3D mapping of glycogenosis-causing mutations in the large regulatory alpha subunit of phosphorylase kinase."
2.	Colorectal Neoplasms (Colorectal Cancer) 06/01/2017 - "Phosphorylase kinase β affects colorectal cancer cell growth and represents a novel prognostic biomarker." 06/01/2017 - "To study the expression and intracellular localization of phosphorylase kinase β (PHKβ) protein in colorectal cancers (CRCs), analyze its correlation with clinicopathological features and prognosis, and study the biological roles and mechanism-of-action of PHKβ in CRC cell lines. "
3.	Alzheimer Disease (Alzheimer's Disease) 09/01/1993 - "In the present study we used 32P-labeled phosphorylase kinase and poly(Glu, Tyr) 4:1 as substrates to measure phosphoprotein phosphatase activities in Alzheimer disease and control brains. "
4.	Glycogen Storage Disease Type Ix 04/15/2022 - "Muscle phosphorylase b kinase (PHK) deficiency is a rare mild metabolic disorder caused by mutations of the PHKA1 gene encoding the αM subunit of PHK. " 03/28/2022 - "GSD type IX α2, the most common subtype of GSD IX, is due to a deficiency of hepatic phosphorylase kinase. " 01/01/2021 - "We performed a systematic literature review in order to collect information on the clinical phenotypes and genotypes of all published GSD VI patients and to compare the data to those for GSD IX, a biochemically and clinically very similar disorder caused by a deficiency of phosphorylase kinase. " 09/25/2020 - "Variability of clinical and biochemical phenotype in liver phosphorylase kinase deficiency with variants in the phosphorylase kinase (PHKG2) gene." 06/01/2020 - "Glycogen storage disease type IX (GSD IX) is caused by a deficiency of hepatic phosphorylase kinase. "
5.	Muscular Diseases (Myopathy) 08/28/1998 - "A splice junction mutation in the alpha(M) gene of phosphorylase kinase in a patient with myopathy." 09/01/1988 - "In the course of work in which the phosphorylase kinase (PhK)-deficient mouse was used as a model of a defined inherited myopathy, we measured the PhK activity in regenerated autografts of normal whole extensor digitorum longus (EDL) muscles. " 01/01/1967 - "Disturbances in the activity of phosphorylase-b-kinase in a case of McArdle myopathy." 02/15/2005 - "Until today, only a few cases of myopathy associated with muscle PhK deficiency caused by a mutation in the gene encoding the alpha subunit of phosphorylase kinase (PHKA1) have been reported. " 08/28/1998 - "In a 28-year-old man with myopathy and phosphorylase kinase (PhK) deficiency, we found a G-to-C substitution at the 5' end of an intron in the muscle-specific alpha-subunit gene. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Phosphoprotein Phosphatases (Phosphatases, Protein)
3.	Calcibiotic Root Canal Sealer
4.	L-glutamic acid-L-tyrosine copolymer
5.	Glycogen
6.	Enzymes
7.	Phosphorylases (Glucan Phosphorylase)
8.	Phosphofructokinases
9.	Protein Isoforms (Isoforms)
10.	Phosphorylase a

Related Therapies and Procedures

1.	Intravenous Administration
2.	Denervation