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Phosphorylase b
The inactive form of GLYCOGEN PHOSPHORYLASE that is converted to the active form PHOSPHORYLASE A via phosphorylation by PHOSPHORYLASE KINASE and ATP.
Networked:
13
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Enzymes and Coenzymes: 1
Enzymes: 152586
Transferases: 6589
Glycosyltransferases: 784
Hexosyltransferases
Glucosyltransferases: 167
Phosphorylases: 508
Phosphorylase b: 13
Experts
1.
Borgdorff, Marinus A J
: 1 article (12/2006)
2.
Kappert, Peter
: 1 article (12/2006)
3.
Oudkerk, Matthijs
: 1 article (12/2006)
4.
Sijens, Paul E
: 1 article (12/2006)
5.
Smit, G Peter
: 1 article (12/2006)
Related Diseases
1.
Muscular Diseases (Myopathy)
12/01/1988 - "
This study examined the effect of three test meals on exercise tolerance of an individual with McArdle's disease, a myopathy characterized by phosphorylase b deficiency.
"
2.
Glycogen Storage Disease Type V (McArdle's Disease)
12/01/1988 - "
This study examined the effect of three test meals on exercise tolerance of an individual with McArdle's disease, a myopathy characterized by phosphorylase b deficiency.
"
3.
Hypoxia (Hypoxemia)
09/30/1983 - "
Cyanide and anoxia may allow phosphorylase b and a to become equally active, or they may trigger a non-phosphorolytic glycogenolysis.
"
09/01/1976 - "
Extracellular Ca2+ is required for contraction, the positive inotropic aciton of catecholamines and phosphorylase b to a conversion by anoxia.
"
12/03/1984 - "
We conclude that in the perfused liver, anoxia and KCN stimulate glycogen breakdown and glucose output, at least in part, by a mechanism that does not involve conversion of phosphorylase b to phosphorylase a.
"
4.
Glycogen Storage Disease Type Ix
11/10/1974 - "
Characterization of the phosphorylase b to a converting activity in skeletal muscle extracts of mice with the phosphorylase b kinase deficiency mutation.
"
08/01/1983 - "
In an assay measuring radioactive incorporation from gamma--P32P]ATP into phosphorylase b, cardiac muscle extracts from mice with the phosphorylase kinase deficiency mutation showed significant, calcium-dependent phosphorylase kinase activity that was 10 to 15% of that of Swiss mice, the control strain.
"
01/01/1981 - "
These two subgroups were distinguished by hemolysate enzyme assays: (1) GSD IX was characterized by a residual phosphorylase kinase activity, a low activation curve for endogenous phosphorylase b and increased amylo-1,6-glucosidase activity.
"
5.
Ischemia
11/01/1990 - "
Conversion of phosphorylase b to a was assessed, because it depends, among other things, on changes in Ca2+i. The K+e value rose within a few seconds following induction of ischemia, but massive depolarization (which is accompanied by influx of calcium) did not occur until after approximately 65 s.
"
01/01/1986 - "
It is concluded that epidermal glycogenolysis in ischemia is, at least in part, a consequence of activation of phosphorylase b by AMP, and that glycogen resynthesis on reperfusion is promoted by the ischemic activation of glycogen synthase.
"
Related Drugs and Biologics
1.
Phosphorylase Kinase (Phosphorylase Kinase, Glycogen)
2.
Glycogen
3.
Calcium
4.
Adenosine Triphosphate (ATP)
5.
Polylysine
6.
Phosphorylase a
7.
Isoproterenol (Isoprenaline)
8.
Glycogen Synthase (Synthase I)
9.
Glucose (Dextrose)
10.
Enzymes