Phosphorylase a

The active form of GLYCOGEN PHOSPHORYLASE that is derived from the phosphorylation of PHOSPHORYLASE B. Phosphorylase a is deactivated via hydrolysis of phosphoserine by PHOSPHORYLASE PHOSPHATASE to form PHOSPHORYLASE B.

Networked: 66 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Bek, Kenan: 1 article (08/2008)
2.	Delibaş, Ali: 1 article (08/2008)
3.	Demircin, Gülay: 1 article (08/2008)
4.	Ezgü, Fatih Süheyl: 1 article (08/2008)
5.	Oksal, Ayşegül: 1 article (08/2008)
6.	Oner, Ayşe: 1 article (08/2008)
7.	Agius, Loranne: 1 article (05/2006)
8.	Aiston, Susan: 1 article (05/2006)
9.	Arden, Catherine: 1 article (05/2006)
10.	Brady, Matthew J: 1 article (05/2006)

Related Diseases

1.	Malignant Hyperthermia 03/01/1983 - "The ratio of muscle phosphorylase a to total phosphorylase, expressed as a percent, was determined in vastus lateralis muscle of 26 patients to examine the efficacy of this parameter as a method for screening for susceptibility to malignant hyperthermia (MH). "
2.	Unstable Angina 01/01/1986 - "The correlation between the platelet aggregation index and phosphorylase A activity and their association with a course of disease indicated an opportunity of using these indices as accessory diagnostic criteria and control over therapeutic efficacy in unstable angina."
3.	Hypoxia (Hypoxemia) 03/01/2000 - "During the last 14 min of exercise, glycogenolysis was greater in hypoxia despite a lower mole fraction of phosphorylase a. " 12/01/1992 - "Hypoxia causes sustained glycogenolysis in skeletal muscle without an increase in percentage of phosphorylase a. " 12/01/1992 - "Hypoxia causes glycogenolysis without an increase in percent phosphorylase a in rat skeletal muscle." 02/15/1990 - "Hence the Km of phosphorylase a for its substrate Pi must be considerably higher than the concentrations that occur in the cytosol, even during hypoxia." 12/01/1988 - "3. We conclude that the hepatic glycogenolysis induced by anoxia and by KCN is solely mediated by phosphorylase a. "
4.	Ischemia 08/15/2002 - "PP2A activity as measured with phosphorylase a as substrate was slightly inhibited after 30 min ischemia followed by 30 min reperfusion, and this inhibition correlated with an increased S6K1 and ERK1/2 phosphorylation. " 12/01/2000 - "Protein phosphatase activity, as measured with [(32)P]phosphorylase a as a substrate, diminished during ischemia and returned to control levels upon 30-min recovery. " 07/01/1996 - "However, the ratio phosphorylase a/a + b was not altered, whatever the conditions, (5) the concentration of inorganic phosphate (Pi) increased sharply during the first minutes of ischemia, to values above 8-10 mM, under all conditions studied. " 01/01/1989 - "To investigate the role of the intracellular calcium ion in the development of acute gastric mucosal lesions, phosphorylase a activity was measured as an index of the intracellular calcium ion concentration ([Ca2+]i), using Lowry's method, in the rat ischemia-reperfusion model. " 01/01/1983 - "In contrast to epinephrine infusion prolonged ischemia resulted in a decrease in the mole fraction of phosphorylase a and simultaneously in an increase of the glycogenolytic rate. "
5.	Hyperthyroidism 03/01/1983 - "However, enhanced phosphorylase a formation was still present in the hearts from hyperthyroid rats following trifluoperazine preperfusion. " 03/01/1983 - "At higher concentrations of isoproterenol (10(-8) M and 3 x 10(-8) M), no significant differences in cAMP formation were noted between euthyroid and hyperthyroid animals in spite of persistently increased phosphorylase a levels in the hyperthyroid state. " 01/01/1977 - "The effect of dibutyryl cyclic AMP on cardiac phosphorylase a activity in euthyroid and hyperthyroid hearts." 03/01/1983 - "At least two mechanisms, an increased sensitivity to beta-adrenergic agents and increased cardiac phosphorylase kinase activity, may mediate the enhanced phosphorylase a formation found in hearts from hyperthyroid rats." 03/01/1983 - "Comparative biochemical analyses revealed increased phosphorylase a formation in hearts from both euthyroid and hyperthyroid animals following exposure to calcium, dibutryl cAMP and isoproterenol. "

Related Drugs and Biologics

1.	Phosphorylases (Glucan Phosphorylase)
2.	Enzymes
3.	Calcium
4.	Glycogen
5.	Glucose (Dextrose)
6.	Liver Glycogen
7.	Glycogen Synthase (Synthase I)
8.	Adenosine Triphosphate (ATP)
9.	Glycogen Phosphorylase (Phosphorylase, Glycogen)
10.	Lactic Acid (Lactate)

Related Therapies and Procedures

1.	Intravenous Administration
2.	Therapeutics
3.	Ligation