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Phosphonoacetic Acid (Phosphonoacetate)

A simple organophosphorus compound that inhibits DNA polymerase, especially in viruses and is used as an antiviral agent.
Also Known As:
Phosphonoacetate; Disodium Phosphonoacetate; Fosfonet Sodium; Phosphonacetic Acid; Phosphonoacetate, Disodium; Acetic acid, phosphono-
Networked: 96 relevant articles (6 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Alandijany, Thamir: 1 article (01/2018)
2. Boutell, Chris: 1 article (01/2018)
3. Conn, Kristen L: 1 article (01/2018)
4. Loney, Colin: 1 article (01/2018)
5. McFarlane, Steven: 1 article (01/2018)
6. Orr, Anne: 1 article (01/2018)
7. Roberts, Ashley P E: 1 article (01/2018)
8. Golais, František: 1 article (01/2017)
9. Kúdelová, Marcela: 1 article (01/2017)
10. Mrázová, Veronika: 1 article (01/2017)

Related Diseases

1. Infections
2. Herpes Simplex
3. Virus Diseases (Viral Diseases)
08/01/1981 - "Maintaining phosphonoacetate in the presence of infected cultures for periods of 7 days or longer resulted in curing and a complete loss of infections virus in the medium and in cell lysates."
08/01/1979 - "The morphogenesis of nuclear inclusions and virus capsids in human embryonic lung cells infected with ts mutants of human cytomegalovirus at permissive (34 degrees C) and non-permissive (39 degrees C) temperatures was studied by indirect immunofluorescence (IF) and electron microscopic analyses and compared with the morphogenesis of these structures in wild-type virus infection with or without phosphonoacetate. "
01/01/1981 - "Detectable myxoma virus replication was inhibited at a drug concentration of 100 micrograms/ml. Fibroma virus replication was inhibited at a concentration of 500 micrograms/ml. Because of this difference in sensitivity, myxoma virus was used to infect rabbits to test that efficacy of phosphonoacetic acid in the treatment of a systemic viral disease. "
08/20/1995 - "AmEPV, like VV, was found to be sensitive to all the inhibitors of viral infection tested including phosphonoacetic acid, 1-beta-D-arabinofuranosylcytosine, and isatin-beta-thiosemicarbazone (IBT), a compound associated with the rather specific inhibition of vertebrate poxviruses. "
04/01/2016 - "The modification of viral infections by virion inactivation and phosphonoacetic acid, cycloheximide, and actinomycin D treatments indicated new protein synthesis is needed to establish superinfection exclusion. "
4. Herpesviridae Infections (Herpesvirus Infection)
5. Latent Infection

Related Drugs and Biologics

1. Ointments (Pastes)
2. Acyclovir (Aciclovir)
3. Thymidine Kinase
4. Protein Synthesis Inhibitors
5. Caffeine (No Doz)
6. Cycloheximide (Cicloheximide)
7. Viral DNA
8. Proteins (Proteins, Gene)
9. Aphidicolin
10. Vidarabine (Vira-A)

Related Therapies and Procedures

1. Therapeutics