Type C Phospholipases

A subclass of phospholipases that hydrolyze the phosphoester bond found in the third position of GLYCEROPHOSPHOLIPIDS. Although the singular term phospholipase C specifically refers to an enzyme that catalyzes the hydrolysis of PHOSPHATIDYLCHOLINE (EC 3.1.4.3), it is commonly used in the literature to refer to broad variety of enzymes that specifically catalyze the hydrolysis of PHOSPHATIDYLINOSITOLS.

Also Known As:

Networked: 1091 relevant articles (13 outcomes, 81 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Jan, Chung-Ren: 21 articles (12/2014 - 03/2002)
2.	Chou, Chiang-Ting: 14 articles (12/2014 - 07/2005)
3.	Lo Vasco, Vincenza Rita: 9 articles (12/2020 - 07/2010)
4.	Jacobson, Kenneth A: 9 articles (05/2014 - 01/2002)
5.	Chang, Hong-Tai: 9 articles (10/2013 - 03/2002)
6.	Cocco, Lucio: 8 articles (03/2022 - 05/2002)
7.	Kanematsu, Takashi: 8 articles (12/2019 - 10/2011)
8.	Kuo, Chun-Chi: 8 articles (12/2014 - 01/2010)
9.	Liang, Wei-Zhe: 8 articles (12/2014 - 11/2011)
10.	Tsai, Jeng-Yu: 8 articles (02/2014 - 01/2009)

Related Diseases

1.	Infections 03/01/1992 - "However, whereas a proportion of wild-type organisms survive this early mechanism of defense to give rise to progressive infection, the phospholipase C-negative organisms are totally eliminated. " 12/15/1992 - "This study has examined the effects of vaccinia virus infection on phospholipase C activity. " 01/01/2023 - "Phospholipase C: underrated players in microbial infections." 10/01/2022 - "Molecular Characterization of Phospholipase C in Infection Structure Differentiation Induced by Pear Fruit Surface Signals, Stress Responses, Secondary Metabolism, and Virulence of Alternaria alternata." 01/01/2022 - "We found seven cellular signaling pathways, including phospholipase C signaling, Pak signaling, and nuclear factor erythroid 2p45-related factor 2 (NRF2)-mediated oxidative stress response signaling, that were inhibited by IAV infection but significantly activated by PSMA2 KD. "
2.	Necrosis 05/01/2013 - "In this study, the immunogenicity and protective efficacy of the C-terminal domain (CP251-370) of the toxin and phospholipase C (PLC; CB, 372 residues) of Clostridum bifermentans isolated from cases of clostridium necrosis were examined. " 06/01/1996 - "It produces the alpha toxin (phospholipase C), which can induce spontaneous tissue necrosis. " 10/01/2006 - "In the presence of a phospholipase C antagonist, U73122, there was significant inhibition of the S1P protective effects against apoptosis/necrosis. " 12/17/2022 - "C. ghonii secreted collagenase IV and phospholipase c and significantly promoted apoptosis and necrosis in cultured A549 cells. " 05/19/2014 - "Mycobacterium tuberculosis expressing phospholipase C subverts PGE2 synthesis and induces necrosis in alveolar macrophages."
3.	Insulin Resistance 06/19/1993 - "Alterations of liver membrane phospholipase C activity in NIDDM, therefore, may reflect diabetic pathology other than the insulin resistance associated with this disease." 06/19/1993 - "Hepatic insulin resistance in KKA(y) mice and its amelioration by pioglitazone do not involve alterations in phospholipase C activity." 05/01/2013 - "The phospholipase C inhibitor U73122 attenuates trans-10, cis-12 conjugated linoleic acid-mediated inflammatory signaling and insulin resistance in human adipocytes." 01/01/2021 - "Dihydromyricetin Ameliorates Inflammation-Induced Insulin Resistance via Phospholipase C-CaMKK-AMPK Signal Pathway." 11/01/2023 - "Results showed that PSP improved glucose tolerance and systemic insulin sensitivity, which coincided with decreased expression of sodium-glucose cotransporter 1 and glucose transporter 2 in the intestinal epithelium induced by an activation of the phospholipase C β2/protein kinase C signaling pathway. "
4.	Hypoxia (Hypoxemia) 01/01/2019 - "In the present study, we examined the function of phospholipase C ϵ-1 (PLCE1) by an H9c2 H/R (H/R, hypoxia-reoxygenation) model and a rat myocardial I/R injury model. " 11/01/2016 - "Surprisingly, the hypoxic upregulation of neutrophil degranulation was not dependent on hypoxia-inducible factor (HIF), nor was it fully reversed by inhibition of phospholipase C signalling. " 02/01/2013 - "We report, for the first time, that acute hypoxia significantly enhances phospholipase C (PLC) activity in mouse resistance pulmonary arteries (PAs), but not in mesenteric arteries. " 12/20/2002 - "Activation of the neuroprotective ERK signaling pathway by fructose-1,6-bisphosphate during hypoxia involves intracellular Ca2+ and phospholipase C." 11/02/2001 - "Neuroprotection and intracellular Ca2+ modulation with fructose-1,6-bisphosphate during in vitro hypoxia-ischemia involves phospholipase C-dependent signaling."
5.	Hemolysis 09/01/2013 - "monocytogenes LII strains, 10403S and EGDe, and compared the flagellar motility, phospholipase C production, hemolysis, and intracellular growth of the mutants and their respective wild types. " 04/01/2006 - "lack of beta-haemolysis and phospholipase C activity, and only the gamma phage assay was specific for B. " 09/01/1993 - "These data suggest that the toxin-induced hemolysis is dependent on the action of phospholipase C in erythrocyte membranes." 09/01/1993 - "Of all toxins produced by the bacterium, phospholipase C (PLC) is believed to be the most likely cause of hemolysis. " 01/01/1989 - "ivanovii produced phospholipase C responsible for the zone of incomplete haemolysis. "

Related Drugs and Biologics

1.	Protein Kinase C
2.	1- (6- ((3- methoxyestra- 1,3,5(10)- trien- 17- yl)amino)hexyl)- 1H- pyrrole- 2,5- dione
3.	Phosphatidylinositols (Phosphatidylinositol)
4.	Proteins (Proteins, Gene)
5.	Calcium
6.	Phosphotransferases (Kinase)
7.	Calmodulin (Calcium-Dependent Activator Protein)
8.	Glucose (Dextrose)
9.	Membrane Proteins (Integral Membrane Proteins)
10.	Mucins

Related Therapies and Procedures

1.	Rewarming
2.	Therapeutics
3.	Transplantation
4.	Ligation
5.	Lasers (Laser)