Phosphogluconate Dehydrogenase (Dehydrogenase, Phosphogluconate)

An enzyme of the oxidoreductase class that catalyzes the reaction 6-phospho-D-gluconate and NADP+ to yield D-ribulose 5-phosphate, carbon dioxide, and NADPH. The reaction is a step in the pentose phosphate pathway of glucose metabolism. (From Dorland, 27th ed) EC 1.1.1.43.

Also Known As:

Networked: 153 relevant articles (1 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Shan, Changliang: 4 articles (10/2020 - 08/2014)
2.	Zhang, Shuai: 4 articles (10/2020 - 11/2015)
3.	Barrett, Michael P: 4 articles (08/2010 - 07/2003)
4.	Gilbert, Ian H: 4 articles (08/2010 - 07/2003)
5.	Bechard, Matthew E: 3 articles (01/2022 - 01/2018)
6.	McDonald, Oliver G: 3 articles (01/2022 - 01/2018)
7.	Chan, Barden: 3 articles (11/2013 - 07/2012)
8.	Sukhatme, Vikas P: 3 articles (11/2013 - 07/2012)
9.	Alibu, Vincent P: 3 articles (08/2010 - 08/2007)
10.	Ruda, Gian Filippo: 3 articles (08/2010 - 08/2007)

Related Diseases

1.	Malaria 08/16/1973 - "An electron cytochemical study of 6-phosphogluconate dehydrogenase activity in infected erythrocytes during malaria." 01/01/1973 - "6-Phosphogluconate dehydrogenase activity in malaria-infected erythrocytes." 01/01/1986 - "Erythrocyte 6-phosphogluconate dehydrogenase A (PGDA) and phosphoglucomutase 1 (PGM1), phenotypes of unknown relevance to protection against falciparum malaria, were also significantly more prevalent in those claiming resistance to malaria. " 10/19/2018 - "The enzyme 6-phosphogluconate dehydrogenase (6PGD) of the malaria parasite Plasmodium falciparum catalyzes the third step of the pentose phosphate pathway converting 6-phosphogluconate (6PG) to ribulose 5-phosphate. " 06/01/1978 - "Electrophoretic variation of the enzymes glucose phosphate isomerase, 6-phosphogluconate dehydrogenase, lactate dehydrogenase and glutamate dehydrogenase (NADP-dependent) has been studied in the African murine malaria parasites Plasmodium berghei, P. "
2.	Falciparum Malaria (Plasmodium falciparum Malaria) 01/01/1986 - "Erythrocyte 6-phosphogluconate dehydrogenase A (PGDA) and phosphoglucomutase 1 (PGM1), phenotypes of unknown relevance to protection against falciparum malaria, were also significantly more prevalent in those claiming resistance to malaria. "
3.	Neoplasms (Cancer) 01/01/2023 - "Critical Role of 6-Phosphogluconate Dehydrogenase in TAp73-Mediated Cancer Cell Proliferation." 01/01/2021 - "Blockade of 6-phosphogluconate dehydrogenase generates CD8+ effector T cells with enhanced anti-tumor function." 01/01/2019 - "Targeting 6-phosphogluconate dehydrogenase (6PGD) can inhibit cancer cell proliferation and tumor growth. " 08/21/2014 - "Although the oxidative pentose phosphate pathway is important for tumor growth, how 6-phosphogluconate dehydrogenase (6PGD) in this pathway is upregulated in human cancers is unknown. " 06/01/1984 - "Increased activity of 6-phosphogluconate dehydrogenase was found in human colon tumors as compared to the adjacent unaffected mucosa. "
4.	Hepatocellular Carcinoma (Hepatoma) 12/01/2020 - "The positive feedback loop between Nrf2 and phosphogluconate dehydrogenase stimulates proliferation and clonogenicity of human hepatoma cells." 01/01/2022 - "Phosphogluconate dehydrogenase is a predictive biomarker for immunotherapy in hepatocellular carcinoma." 12/01/2020 - "The present study was intended to explore the potential role of phosphogluconate dehydrogenase (PGD), one of the PPP enzymes, in the proliferation and migration of human hepatoma HepG2 cells. " 05/01/1979 - "The activities of glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and transketolase were studied in the cytoplasmic fractions of transplanted mouse hepatomas differing in their growth rates, and in the liver, spleen and cortical layer of kidneys of tumour carriers and normal mice. " 01/01/2003 - "In this study, the kinetic properties of G6PD activity were determined in situ in chemically induced hepatocellular carcinomas, and extralesional and control parenchyma in rat livers and were directly compared with those of the second NADPH-producing enzyme of the pentose phosphate pathway, phosphogluconate dehydrogenase (PGD). "
5.	African Trypanosomiasis (Nagana) 08/26/2010 - "RNAi and enzymatic studies have shown the importance of 6-phosphogluconate dehydrogenase (6-PGDH) in Trypanosoma brucei for the parasite survival and make it an attractive drug target for the development of new treatments against human African trypanosomiasis. " 12/01/2007 - "6-Phosphogluconate dehydrogenase is a potential target for new drugs against African trypanosomiasis. " 07/17/2003 - "Synthesis and biological evaluation of substrate-based inhibitors of 6-phosphogluconate dehydrogenase as potential drugs against African trypanosomiasis." 07/15/2010 - "The enzyme 6-phosphogluconate dehydrogenase is a potential drug target for the parasitic protozoan Trypanosoma brucei, the causative organism of human African trypanosomiasis. " 08/01/2007 - "We have previously reported the discovery of potent and selective inhibitors of 6-phosphogluconate dehydrogenase, the third enzyme of the phosphate pentose pathway, from Trypanosoma brucei, the causative organism of human African trypanosomiasis. "

Related Drugs and Biologics

1.	Phosphoglucomutase
2.	Glucosephosphate Dehydrogenase (Glucose 6 Phosphate Dehydrogenase)
3.	Enzymes
4.	Prostaglandins D
5.	Glutathione Reductase (Glutathione-Disulfide Reductase)
6.	Glucose (Dextrose)
7.	Oxidoreductases (Dehydrogenase)
8.	Pyruvate Kinase
9.	NADP (NADPH)
10.	Glutathione Peroxidase

Related Therapies and Procedures

1.	Mastectomy (Mammectomy)
2.	Injections
3.	Immunotherapy
4.	Drug Therapy (Chemotherapy)