|1.||Kazanietz, Marcelo G: 10 articles (01/2012 - 01/2002)|
|2.||Blumberg, Peter M: 5 articles (05/2014 - 01/2002)|
|3.||Kedei, Noemi: 4 articles (05/2014 - 04/2008)|
|4.||Lewin, Nancy E: 4 articles (05/2014 - 04/2008)|
|5.||Basu, Alakananda: 3 articles (08/2013 - 11/2009)|
|6.||Stone, James C: 3 articles (01/2013 - 08/2003)|
|7.||Caino, M Cecilia: 3 articles (04/2011 - 01/2008)|
|8.||Irie, Kazuhiro: 3 articles (01/2011 - 05/2003)|
|9.||Xiao, Liqing: 3 articles (10/2009 - 11/2005)|
|10.||Kelsey, Jessica S: 2 articles (05/2014 - 01/2013)|
04/01/2015 - "The objective of this study is to evaluate the components and tumor promoting activity of phorbol esters in Jatropha oil cake-supplemented soil and plants grown in the treated soil. "
10/01/2000 - "The structure-activity relationship study of phorbol esters and teleocidines whose tumor promotion is epigenetic, was extensively studied. "
10/01/1997 - "In earlier studies using several inbred mouse strains, we found that susceptibility to skin tumor promotion by phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate (TPA) is a multigenic trait. "
01/01/1989 - "[Effect of tumor-promoting phorbol esters on retrovirus-infected human cells: scanning electron microscopy studies]."
02/01/1988 - "The objective of this study was to determine whether the tumor-promoting phorbol esters can induce vascular growth. "
|2.||Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
08/01/1983 - "Phorbol diesters induce macrophage-like differentiation in KG-1 and HL-60 human acute myelogenous leukemia cell lines. "
11/01/1980 - "Phorbol esters, including 12-O-tetradecanoylphorbol 13-acetate (TPA), induce terminal macrophagelike differentiation of cells from human acute myelogenous leukemia lines. "
07/01/1986 - "Differential effects of phorbol esters on normal myeloid precursors and leukemic cells: basis for autologous bone marrow reconstitution in acute nonlymphocytic leukemia using phorbol ester-treated bone marrow from patients in remission."
06/01/1989 - "The expression of the myeloperoxidase (MPO) gene was studied, by means of Northern blot analysis in 14 cases of acute myeloid leukemia (AML), 11 cases of chronic myeloid leukemia (CML), and 6 cases of CML blast crisis, and in HL60 cells before and after induction of terminal differentiation with retinoic acid (RA), phorbol esters (TPA), or vitamin D. "
04/01/1990 - "On the other hand, in C57BL/6J mice, which are resistant to promotion by phorbol esters under the usual protocols, the edema response to PMA was totally eliminated by RTX pretreatment during the first 8 h after PMA administration. "
02/01/1987 - "The immunosuppressive agent Didemnin B (DB) inhibits biological effects that are induced by topical application of phorbol esters to mouse skin as measured by mouse ear edema and the alkaline phosphatase activity of mouse epidermis. "
11/01/1989 - "For other phorbol esters, 12-deoxyphorbol mono- and diesters, and mezerein, differing kinetics of edema and differing degrees of blockade of edema following resiniferatoxin pretreatment were observed, as expected from the discrepancies between their inflammatory and tumor-promoting activities. "
05/29/1992 - "In skin of CD-1 mice, high doses of prostratin induced ornithine decarboxylase only to 25-30% of the levels induced by typical phorbol esters at doses 1/30 or less than that used for prostratin, produced kinetics of edema formation characteristic of the nonpromoting 12-deoxyphorbol 13-phenylacetate, and failed to induce the acute or chronic hyperplasias typically caused by tumor-promoting phorbols at doses of 1/100 or less than that used for prostratin."
11/01/1998 - "The human monocytic leukemia cell line THP-1 differentiates into macrophage-like cells when treated with phorbol esters. "
03/27/1998 - "Phorbol esters exert a dual function in human leukemia cells, induction of differentiation and activation of integrin-mediated functions. "
04/01/1992 - "Phorbol esters augment polyamine transport by influencing Na(+)-K+ pump in murine leukemia cells."
07/01/1988 - "Functional and morphological differentiation induction of a human megakaryoblastic leukemia cell line (MEG-01s) by phorbol diesters."
01/01/1988 - "Phorbol esters potentiate glucocorticoid-induced cytotoxicity in CEM-C7 human T-leukemia cell line."
03/01/1995 - "The effects of phorbol esters on Ca2+ channel currents in human neuroblastoma SH-SY5Y cells were studied using whole-cell patch-clamp recordings. "
08/01/1993 - "Long-term exposure of human neuroblastoma cells to phorbol esters results in down-regulation of PKC activity and induction of neuronal differentiation. "
01/01/1990 - "The human neuroblastoma cell line, SH-SY5Y, differentiates into neuron-like cells according to morphological, biochemical and functional criteria when treated with biologically active phorbol-esters. "
08/23/2005 - "Here, we show that in human neuroblastoma SH-SY5Y cells, neuron-specific ELAV (nELAV) proteins (HuB, HuC, and HuD) are up-regulated and redistributed by 15 min of treatment with the activators of PKC phorbol esters and bryostatin-1. "
03/01/1995 - "Enhancement of Ca2+ channel currents in human neuroblastoma (SH-SY5Y) cells by phorbol esters with and without activation of protein kinase C."
|3.||Adenylate Cyclase (Adenylyl Cyclase)
|5.||Protein Kinase C
|7.||DNA (Deoxyribonucleic Acid)
|10.||Tretinoin (Retinoic Acid)
|2.||Investigational Therapies (Experimental Therapy)