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Lactase-Phlorizin Hydrolase

A multifunctional protein that contains two enzyme domains. The first domain (EC 3.2.1.62) hydrolyzes glycosyl-N-acylsphingosine to a sugar and N-acylsphingosine. The second domain (EC 3.2.1.108) hydrolyzes LACTOSE and is found in the intestinal brush border membrane. Loss of activity for this enzyme in humans results in LACTOSE INTOLERANCE.
Also Known As:
Glycosyl Ceramidase; Lactase-Glycosylceramidase; Ceramidase, Glycosyl; Hydrolase, Lactase-Phlorizin; Hydrolase, Phlorizin; Lactase Glycosylceramidase; Lactase Phlorizin Hydrolase; Phloretin Glucosidase; Glycosylceramidase; Phloretin-Glucosidase; Phlorizin Hydrolase
Networked: 34 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Naim, Hassan Y: 2 articles (01/2022 - 02/2019)
2. Wanes, Dalanda: 2 articles (01/2022 - 02/2019)
3. Hemminki, Jukka: 2 articles (11/2008 - 10/2006)
4. Hutri-Kähönen, Nina: 2 articles (11/2008 - 10/2006)
5. Kähönen, Mika: 2 articles (11/2008 - 10/2006)
6. Laaksonen, Marika: 2 articles (11/2008 - 10/2006)
7. Lehtimäki, Terho: 2 articles (11/2008 - 10/2006)
8. Mikkilä, Vera: 2 articles (11/2008 - 10/2006)
9. Raitakari, Olli: 2 articles (11/2008 - 10/2006)
10. Räsänen, Leena: 2 articles (11/2008 - 10/2006)

Related Diseases

1. Lactose Intolerance (Intolerance, Lactose)
2. Adenocarcinoma
3. Congenital Lactase Deficiency
4. Malnutrition (Nutritional Deficiencies)
5. Osteoporotic Fractures

Related Drugs and Biologics

1. Enzymes
2. Sucrase (Sucrose alpha-D-Glucohydrolase)
3. Oligo-1,6-Glucosidase (Isomaltase)
4. CD13 Antigens (Alanine Aminopeptidase)
5. Hydrolases
6. Antibodies
7. Lactase
8. Proteins (Proteins, Gene)
9. Lactose
10. Lactic Acid (Lactate)