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Philadelphia Chromosome

An aberrant form of human CHROMOSOME 22 characterized by translocation of the distal end of chromosome 9 from 9q34, to the long arm of chromosome 22 at 22q11. It is present in the bone marrow cells of 80 to 90 per cent of patients with chronic myelocytic leukemia (LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE).
Also Known As:
Ph 1 Chromosome; 1 Chromosome, Ph; 1 Chromosomes, Ph; Chromosome, Ph 1; Chromosome, Ph1; Chromosome, Philadelphia; Chromosomes, Ph 1; Chromosomes, Ph1; Ph 1 Chromosomes; Ph1 Chromosomes; Ph1 Chromosome
Networked: 1672 relevant articles (207 outcomes, 161 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
2. BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
3. Leukemia
4. Residual Neoplasm
5. Chromosome Aberrations (Chromosome Abnormalities)

Experts

1. Cortes, Jorge: 56 articles (11/2015 - 04/2002)
2. O'Brien, Susan: 54 articles (11/2015 - 04/2002)
3. Kantarjian, Hagop: 49 articles (11/2015 - 02/2002)
4. Kantarjian, Hagop M: 44 articles (12/2015 - 04/2002)
5. Garcia-Manero, Guillermo: 35 articles (12/2015 - 04/2002)
6. Talpaz, Moshe: 35 articles (11/2013 - 02/2002)
7. Faderl, Stefan: 31 articles (12/2015 - 04/2002)
8. Verstovsek, Srdan: 26 articles (12/2015 - 05/2002)
9. Hochhaus, Andreas: 26 articles (07/2014 - 02/2002)
10. Giles, Francis: 26 articles (11/2007 - 01/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Philadelphia Chromosome:
1. imatinib (Gleevec)FDA Link
2. Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
3. dasatinib (BMS 354825)FDA Link
4. Interferon-alpha (Interferon Alfa)FDA Link
5. Bcr-Abl tyrosine kinaseIBA
6. 4- methyl- N- (3- (4- methylimidazol- 1- yl)- 5- (trifluoromethyl)phenyl)- 3- ((4- pyridin- 3- ylpyrimidin- 2- yl)amino)benzamide (nilotinib)FDA Link
7. Phosphotransferases (Kinase)IBA
8. Busulfan (Busulfex)FDA Link
9. Messenger RNA (mRNA)IBA
10. InterferonsIBA

Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Stem Cell Transplantation
04/01/2013 - "To analyse the outcome of adult patients who developed a first relapse of acute lymphoblastic leukaemia (ALL), we collected the clinical data of 332 patients with Philadelphia-chromosome (Ph) negative ALL, aged 16-65 years, who relapsed after first complete remission (CR1) between 1998 and 2008 in 69 institutions all over Japan, including 58 patients who relapsed after allogeneic haematopoietic stem cell transplantation (Allo-HSCT) in CR1. "
04/01/2013 - "Re-emerging Philadelphia chromosome-positive acute leukaemia more than 20 years after allogeneic haematopoietic stem cell transplantation."
01/01/2015 - "In a multicentre, single-arm, open-label phase 2 study, we enrolled adult patients with Philadelphia-chromosome-negative, primary refractory or relapsed (first relapse within 12 months of first remission, relapse within 12 months after allogeneic haemopoietic stem-cell transplantation [HSCT], or no response to or relapse after first salvage therapy or beyond) leukaemia. "
04/16/2015 - "Because a pediatric-inspired Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) protocol yielded a markedly improved outcome in adults with Philadelphia chromosome-negative ALL, we aimed to reassess the role of allogeneic stem cell transplantation (SCT) in patients treated in the GRAALL-2003 and GRAALL-2005 trials. "
10/01/2002 - "From 1994 to 2000, 154 adults with Philadelphia chromosome-positive (Ph(+)) and/or BCR-ABL(+) acute lymphoblastic leukemia (ALL) were treated according to a prospective trial (median follow-up, 4.5 years) with the aim to study the prognostic value of early response to therapy and the role of stem cell transplantation (SCT) in first complete remission (CR). "
3. Transplantation (Transplant Recipients)
4. Bone Marrow Transplantation (Transplantation, Bone Marrow)
5. Hematopoietic Stem Cell Transplantation