Phenylthiourea (Phenylthiocarbamide)

Phenylthiourea is a THIOUREA derivative containing a phenyl ring. Depending on their genetic makeup, humans can find it either bitter-tasting or tasteless.

Also Known As:

Phenylthiocarbamide; Thiourea, phenyl-

Networked: 102 relevant articles (1 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Urea: 15015
    - Thiourea: 362
      - Phenylthiourea: 102
        thiocarlide: 53
        Thiophanate: 26
        thiambutosine: 14
        ethoxyd: 10
        N-phenyl-N'-3-hydroxyphenylthiourea: 4
        Phenylthiazolylthiourea: 2
        butomelide: 1
        N-(phenylcarbothiol)benzamide: 1
        1-(2-aminoethyl)-3-(2,6-dichlorophenyl)thiourea
        1-(2-aminoethyl)-3-phenylthiourea
        1-(3,4-dichlorophenyl)-2-thiourea
        1-(3-azido-4-chlorophenyl)-2-thiourea
        1-(3-azido-4-chlorophenyl)-3-methyl-2-thiourea
        1-(4-fluorophenyl)-3-(4-(1-((pyridine-4-carbonyl)hydrazono)ethyl)phenyl)thiourea
        1-(4-pentyloxy-3-trifluoromethylphenyl)-3-(pyridine-3-carbonyl)thiourea
        1-(5-aminopentyl)-3-phenylthiourea
        1-acetyl-3-phenylamidine thiocarbamide
        2-hydroxyphenylthiourea
        4-amino-3-(3'-methoxycarbonyl-2'-thioureido)benzophenone
        benzylthiourea
        diafenthiuron
        N-(2-chloro benzoyl)-N'-phenylthiourea
        N-(fluoresceinyl)-N'-(1-(6-(3-mercapto-2-benzyl-1-oxopropyl)amino)-1-hexyl)thiocarbamide
        N-2-aminophenyl-N'-thiourea
        Nile blue-based chemodosimeter
        U 10157
- Sulfur Compounds: 278
  - Thiourea: 362
    - Phenylthiourea: 102

Experts

1.	Moberg, Paul J: 5 articles (12/2012 - 04/2005)
2.	Turetsky, Bruce I: 4 articles (12/2012 - 04/2005)
3.	Gur, Raquel E: 3 articles (12/2012 - 04/2005)
4.	Kanes, Stephen J: 3 articles (12/2012 - 04/2005)
5.	Balderston, Catherine C: 3 articles (09/2007 - 04/2005)
6.	Roalf, David R: 3 articles (09/2007 - 04/2005)
7.	Belousova, Irina A: 2 articles (05/2021 - 01/2017)
8.	Ignatieva, Anastasia N: 2 articles (05/2021 - 01/2018)
9.	Martemyanov, Vyacheslav V: 2 articles (05/2021 - 01/2017)
10.	Tokarev, Yuri S: 2 articles (05/2021 - 01/2018)

Related Diseases

1.	Necrosis 09/01/1994 - "In aged tubers, phenylthiourea (PTU) causes a significant reduction of AA-induced cell necrosis. "
2.	Goiter 06/01/1975 - "I. Demographic study on the relation of taste distinction of PTC (Phenylthiocarbamide) to the quantity and quality of goiter in 61,490 subjects in Czechoslovakia]." 08/01/1990 - "Possible relations between sensitivity to phenylthiocarbamide and goiter." 11/11/1966 - "[The phenylthiocarbamide test in subjects with malignant goiter]." 01/01/1968 - " The effect of the treatment of established goiters in adolescent girls with thyroxine is described, as are results of the studies of the ability to taste phenylthiocarbamide, a property which may be genetically linked to a predisposition to goiter. "
3.	Melanoma (Melanoma, Malignant) 12/13/1999 - "Inhibition of L-tyrosine-induced micronuclei production by phenylthiourea in human melanoma cells." 03/31/1992 - "Phenylthiourea, a specific inhibitor of tyrosinase activity, partially blocked the growth inhibitory activity of N-Ac-4-S-CAP in human pigmented melanoma cells. " 09/01/2022 - "Treatment of pigmented B16-F0 and WM35 melanoma cells with the melanin synthesis inhibitor phenylthiourea for 48 h led to cell depigmentation and enhanced cell death after irradiation, whereas a 3-h period of inhibition did not modify melanin content but produced a marked reduction of Pc13 phototoxicity, together with a decrease of oxidative melanin synthesis intermediates. " 09/15/2008 - "We tested this concept in human melanoma cells cultured in either Ham's F10 medium to maintain amelanotic phenotype or DMEM to induce/stimulate melanin production, respectively; N-phenylthiourea (PTU) and D-penicillamine were used as an inhibitor of melanogenesis. " 12/13/1999 - "L-Tyrosine oxidation product(s) increased the frequency of micronuclei in melanoma cells; 0.1 mM phenylthiourea (PTU), an inhibitor of L-tyrosine oxidation by tyrosinase, lowered the micronucleus production to the control levels. "
4.	Ageusia (Hypogeusia) 02/01/2007 - "The inability to taste phenylthiocarbamide (PTC; "taste-blindness") has been associated with a number of medical and neurological illnesses not typically related to taste. " 11/30/1998 - "Taste blindness to phenylthiocarbamide (PTC) and its chemical relative 6-n-propylthiouracil (PROP) was discovered in the 1930s. " 12/01/1994 - "Taste worlds of humans vary because of taste blindness to phenylthiocarbamide (PTC) and its chemical relative, 6-n-propylthiouracil (PROP). " 04/01/1968 - "Phenylthiourea taste blindness and MMPI personality patterns in adult Caucasion females." 09/01/1951 - "Concerning taste-blindness to phenylthiocarbamide."
5.	Thyroid Diseases (Thyroid Disease) 04/15/2009 - "The aim of the study was to reveal a relationship between gustatory sensitivity to phenylthiocarbamide (PTC) and thyroid disease. " 04/15/2009 - "[Study of gustatory sensitivity to phenylthiocarbamide in thyroid diseases]." 08/01/1990 - "Taste sensitivity to phenylthiocarbamide (PTC) using the Harris-Kalmus method was studied in 193 patients with thyroid disease and in a control sample of 311 individuals living in the Emilia area of Italy. " 11/01/1977 - "HLA and phenylthiocarbamide (PTC) tasting in autoimmune thyroid disease." 09/01/1963 - "PHENYLTHIOUREA TASTE TESTING IN HIROSHIMA SUBJECTS WITH THYROID DISEASE."

Related Drugs and Biologics

1.	Monophenol Monooxygenase (Tyrosinase)
2.	Sucrose (Saccharose)
3.	Citric Acid (Citrate)
4.	Sodium Chloride
5.	Blood Group Antigens (Blood Groups)
6.	1-phenyl-3,3-dimethyltriazene (PDT)
7.	Thyroxine (Levothyroxine)
8.	Caffeine (No Doz)
9.	hypericin
10.	Tyrosine (L-Tyrosine)

Related Therapies and Procedures

1.	Therapeutics
2.	Photochemotherapy (Photodynamic Therapy)