Phenothiazines

08/01/1976 - "Possible reasons for the improved prognosis in schizophrenia are considered to be short initial hospitalization, almost universal use of phenothiazines, use of developing community services (social and psychiatric), and generally good econimic conditions."
01/01/1967 - "Prediction of improvement in schizophrenia under four phenothiazines."
02/04/1961 - "A comparative evaluation of two phenothiazines in the management of chronic schizophrenia."
01/01/1978 - "Outcome was better than in most earlier studies of schizophrenia, but similar to that in some other recent studies of first-admission patients; also, the use of phenothiazines, short-term hospitalization, and community services may play a part. "
11/01/1972 - "Work study in the assessment of the effects of phenothiazines in schizophrenia."

05/01/2019 - "If the etiological approach is essential and sometimes sufficient, symptomatic relief can be helped by some agents with less intense nausea and shorter duration especially by using of antihistaminics, anticholinergic agents and derivatives of phenothiazines."
02/01/2002 - "Common agents administered for nausea are butyrophenones, phenothiazines, metoclopramide, and serotonin-receptor antagonists. "
12/01/1984 - "Phenothiazines and butyrophenones have been the mainstays of most antiemetic therapy but unfortunately have only partially controlled nausea and vomiting. "
01/01/2001 - "Nausea and vomiting are common symptoms of migraine, which can be controlled with a variety of anti-emetics including phenothiazines and antihistamines. "
07/01/1991 - "Antihistamines and phenothiazines were the drugs most commonly used for agents causing mild or moderate nausea and vomiting, and metoclopramide hydrochloride/antihistamines with lorazepam and/or corticosteroids were used most often for chemotherapeutic agents causing severe nausea and vomiting. "

01/01/2021 - "Several studies on phenothiazines against cancer and protozoa have revealed that these compounds show IC50 values in the micromolar and near nanomolar range. "
09/01/1992 - "In order to study the correlation between the anti-tumor activity of benzo[a]phenothiazines and the electron densities, the Huckel orbital method and modified-neglect-of-diatomic overlap (MNDO) orbital method were used. "
08/01/1983 - "This study suggests the possible novel use of phenothiazines to improve drug sensitivity of tumors resistant to ADR treatment."
06/05/2023 - "This review aims in disclosing the use of phenothiazines during the last five years for the development of different anti-cancer drug candidates. "
06/05/2023 - "Phenothiazines as anti-cancer agents: SAR overview and synthetic strategies."

10/01/2009 - "The relative efficacy of phenothiazines for the treatment of acute migraine: a meta-analysis."
10/01/2009 - "We searched MEDLINE, EMBASE, CINAHL, Cochrane database, and international clinical trial registers for randomized controlled trials comparing parenteral phenothiazines with placebo or another active parenteral agent for treatment of acute migraine in adults. "
08/01/2010 - "Phenothiazines in migraine treatment."
04/20/2010 - "Review: phenothiazines relieve acute migraine headaches in the ED and are better than other active agents for some outcomes."
10/01/2009 - "Phenothiazines are more effective than placebo for the treatment of migraine headache and have higher rates of clinical success than other agents against which they have been compared."

01/01/1981 - "The influence of phenothiazines on pain experience is uncertain."
07/01/1992 - "Due to the fact that the double-blind clinical studies of pain are mainly subjective, and difficult to quantify, the usefulness of phenothiazines for the sole purpose of potentiation of analgesia is questionable, especially in view of the many side effects of this group of drugs."
01/01/1959 - "II. Treatment of pain syndromes (nerve root pains, headaches) by phenothiazines]."
08/01/1996 - "Elders, especially if demented, may not have the usual external "pain behaviors." 3. Do not routinely use antiemetics, especially phenothiazines. "
05/01/1979 - "Because of the lack of data supportive of analgesic activity and the adverse reactions associated with phenothiazines, use of these agents in the management of pain should be discouraged. "