|1.||Anisimov, Vladimir N: 4 articles (11/2015 - 01/2003)|
|2.||Lea, Michael A: 3 articles (11/2015 - 02/2011)|
|3.||Abt, Evan: 2 articles (11/2015 - 02/2013)|
|4.||Fishbein, Michael C: 2 articles (11/2015 - 02/2013)|
|5.||Seki, Atsuko: 2 articles (11/2015 - 02/2013)|
|6.||Shackelford, David B: 2 articles (11/2015 - 02/2013)|
|7.||Yang, Yi Yan: 2 articles (01/2015 - 11/2014)|
|8.||Tan, Min-Han: 2 articles (01/2015 - 11/2014)|
|9.||Gao, Shujun: 2 articles (01/2015 - 11/2014)|
|10.||Krishnamurthy, Sangeetha: 2 articles (01/2015 - 11/2014)|
04/01/1998 - "Efficacy of continuous venovenous haemofiltration (CVVH) in the treatment of severe phenformin-induced lactic acidosis."
12/01/1983 - "The results may help to explain lactic acidosis in patients given phenformin in the absence of other predisposing factors."
09/01/1979 - "Detailed hemodynamic and metabolic studies were performed during the course of phenformin related lactic acidosis in two patients. "
07/01/2013 - "Phenformin was removed from the markets before 1970, because it caused lactic acidosis in 40-65 patients in 100,000 patient-years. "
03/01/2013 - "Lactic acidosis provoked by iv infusion of phenformin was weaker in octn1(-/-) mice than that in wild-type mice. "
02/11/2013 - "This study suggests phenformin as a cancer metabolism-based therapeutic to selectively target LKB1-deficient tumors."
02/11/2013 - "Therapeutic trials in Kras-dependent mouse models of NSCLC revealed that tumors with Kras and Lkb1 mutations, but not those with Kras and p53 mutations, showed selective response to phenformin as a single agent, resulting in prolonged survival. "
01/01/1978 - "adult-onset diabetes, artherosclerosis and cancer, and suggest studies on possible antitumour effect of phenformin in man."
03/01/2015 - "Results indicated Phenformin showed synergistic effect and could induce more cancer cell apoptosis and inhibition of tumor growth compared with ionizing radiation alone. "
01/01/2015 - "Collectively, these findings highlight that inhibition of the MCT/BSG complexes alone or in combination with phenformin provides an acute anticancer strategy to target highly glycolytic tumors. "
|3.||Breast Neoplasms (Breast Cancer)
01/01/2015 - "In this study, we reveal the role of phenformin in cell death of the MCF7, ZR-75-1, MDA-MB-231 and SUM1315 breast cancer cell lines. "
03/13/2012 - "Phenformin has clinical potential as an antineoplastic agent and should be considered for clinical trials both in ER-positive and triple-negative breast cancer."
01/01/2015 - "Interestingly, phenformin induced MET (mesenchymal-epithelial transition) and decreased the migration rate in breast cancer cell lines. "
01/01/2015 - "However, little attention has been given to the role of phenformin in breast cancer. "
03/13/2012 - "Phenformin as prophylaxis and therapy in breast cancer xenografts."
|5.||Body Weight (Weight, Body)
01/01/2005 - "Treatment with phenformin did not significantly influence food and water consumption, body weight, and temperature when compared with the ad libitum fed controls. "
10/01/1975 - "Contrary to other reports body weight increased during phenformin treatment. "
02/01/1989 - "Body weight values were not significantly different between phenformin and metformin. "
09/23/1977 - "After eight weeks of treatment with phenformin alone or in combination with clofibrate the body weight decreased significantly (1,9% or 1,4%). "
01/01/1969 - "Phenformin effect on body weight, lipids and glucose regulation."
|2.||Heterologous Transplantation (Xenotransplantation)
|3.||Drug Therapy (Chemotherapy)