Phencyclidine Abuse

The misuse of phencyclidine with associated psychological symptoms and impairment in social or occupational functioning.

Also Known As:

Abuse, Angel Dust; Abuse, PCP; Abuse, Phencyclidine; Phencyclidine Abuses; Phencyclidine Related Disorders; Phencyclidine-Related Disorder; Angel Dust Abuse; PCP Abuse; Phencyclidine-Related Disorders

Networked: 37 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Alcoholism (Alcohol Abuse)
2.	Substance-Related Disorders (Drug Abuse)
3.	Schizophrenia (Dementia Praecox)
4.	Psychotic Disorders (Schizoaffective Disorder)
5.	Substance Withdrawal Syndrome (Withdrawal Symptoms)

Experts

1.	Bécamel, Carine: 1 article (01/2022)
2.	Delagrange, Marine: 1 article (01/2022)
3.	Doyle, Joseph P: 1 article (01/2022)
4.	Heintz, Nathaniel: 1 article (01/2022)
5.	Iyer, Keerthana: 1 article (01/2022)
6.	Paul, Maëla A: 1 article (01/2022)
7.	Selimi, Fekrije: 1 article (01/2022)
8.	Sigoillot, Séverine M: 1 article (01/2022)
9.	Urrieta-Chávez, Beetsi: 1 article (01/2022)
10.	Usardi, Alessia: 1 article (01/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Phencyclidine Abuse:

1.	Clozapine (Clozaril)FDA LinkGeneric 07/01/1998 - "Furthermore, our results suggest that the prototype (clozapine) and a candidate (M100907) atypical APDs might be effective in ameliorating schizophrenic symptoms including cognitive and neuropsychological deficits, which are induced in humans who abuse PCP. "
2.	volinanserinIBA 07/01/1998 - "Furthermore, our results suggest that the prototype (clozapine) and a candidate (M100907) atypical APDs might be effective in ameliorating schizophrenic symptoms including cognitive and neuropsychological deficits, which are induced in humans who abuse PCP. "
3.	Phencyclidine (Angel Dust)IBA 05/01/1986 - "As a result of frequent phencyclidine (PCP) abuse, pyrolysis studies were conducted to further investigate its fate during smoking. " 05/01/2012 - "Clinical data indicate that phencyclidine (PCP) abuse may induce symptoms resembling negative symptoms in humans. " 03/01/1997 - "= drugs of abuse; PCP = phencyclidine; GC/MS = gas chromatography/mass spectrometry." 05/18/1990 - "Phencyclidine (PCP) abuse is reaching alarming proportions. " 01/01/1989 - "Despite the persistence of phencyclidine (PCP) abuse as a public health problem in many urban areas of the United States, there are no published data on outpatient treatment outcome. "
4.	LigandsIBA 10/31/1996 - "Further studies using receptor selective ligands and sensitive probes that could associate with the pharmacological actions of PCP may elucidate the mechanisms of PCP abuse."
5.	Cocaine (Cocaine HCl)IBA 12/27/2006 - "Transcriptional changes common to human cocaine, cannabis and phencyclidine abuse." 12/27/2006 - "Microarray analysis was employed to assay brain gene expression in postmortem anterior prefrontal cortex (aPFC) from 42 human cocaine, cannabis and/or phencyclidine abuse cases and 30 control cases, which were characterized by toxicology and drug abuse history. " 01/01/1987 - "Space-based abstinence: alleviation of withdrawal symptoms in combinative cocaine-phencyclidine abuse." 03/01/1986 - "Treatment of depression in chronic cocaine and phencyclidine abuse with desipramine." 04/01/1996 - "A simple and rapid screening procedure with Triage has been developed to detect 7 classes of drugs of abuse, phencyclidine (PCP), benzodiazepines (BZO), cocaine metabolite (COC), amphetamines (AMP), cannabinoids (THC), opiates (OPI), and barbiturates (BAR), in hemolyzed blood. "
6.	Antipsychotic Agents (Antipsychotics)IBA 07/01/1998 - "These effects are similar to those produced by many atypical antipsychotics and suggests that this class of drugs should be investigated further for their potential utility as antipsychotics and as treatments for PCP abuse." 05/01/1984 - "Four patients are described who had a history of PCP abuse, prolonged psychosis, and poor neuroleptic response. " 01/01/1988 - "Phencyclidine (PCP) abuse usually causes a short, self-limited period of intoxication but may lead to a prolonged psychosis, poorly responsive to antipsychotic medications. "
7.	Ketamine FDA LinkGeneric 01/12/2004 - "The latter finding suggests that other NMDA receptor antagonists (e.g., the drugs of abuse--phencyclidine and ketamine) may also interact synergistically with GHB." 08/15/2001 - "Apoptogenic agents include anesthetics (ketamine, nitrous oxide, isoflurane, propofol, halothane), anticonvulsants (benzodiazepines, barbiturates), and drugs of abuse (phencyclidine, ketamine, ethanol). "
8.	BenzodiazepinesIBA 04/01/1996 - "A simple and rapid screening procedure with Triage has been developed to detect 7 classes of drugs of abuse, phencyclidine (PCP), benzodiazepines (BZO), cocaine metabolite (COC), amphetamines (AMP), cannabinoids (THC), opiates (OPI), and barbiturates (BAR), in hemolyzed blood. " 08/15/2001 - "Apoptogenic agents include anesthetics (ketamine, nitrous oxide, isoflurane, propofol, halothane), anticonvulsants (benzodiazepines, barbiturates), and drugs of abuse (phencyclidine, ketamine, ethanol). "
9.	BarbituratesIBA 04/01/1996 - "A simple and rapid screening procedure with Triage has been developed to detect 7 classes of drugs of abuse, phencyclidine (PCP), benzodiazepines (BZO), cocaine metabolite (COC), amphetamines (AMP), cannabinoids (THC), opiates (OPI), and barbiturates (BAR), in hemolyzed blood. " 08/15/2001 - "Apoptogenic agents include anesthetics (ketamine, nitrous oxide, isoflurane, propofol, halothane), anticonvulsants (benzodiazepines, barbiturates), and drugs of abuse (phencyclidine, ketamine, ethanol). "
10.	Opiate AlkaloidsIBA 04/01/1996 - "A simple and rapid screening procedure with Triage has been developed to detect 7 classes of drugs of abuse, phencyclidine (PCP), benzodiazepines (BZO), cocaine metabolite (COC), amphetamines (AMP), cannabinoids (THC), opiates (OPI), and barbiturates (BAR), in hemolyzed blood. "

Therapies and Procedures

1.	Self Administration (Administration, Self) 10/01/1992 - "This study demonstrates that one drug of abuse, PCP, can serve as a discriminative stimulus when another drug of abuse, ethanol, serves as the reinforcing stimulus, and is the first explicit laboratory demonstration of drug discriminative stimulus control during drug self-administration."
2.	General Anesthesia 07/06/1984 - "This finding has implications for PCP abuse and also for the use of its derivative in general anesthesia, where it may contribute to postoperative infection."
3.	Aftercare (After-Treatment) 01/01/1988 - "Follow-up at 14 to 21 months after treatment show that recovery was maintained except in one subject who relapsed after continuing to abuse PCP. "