Phalloidine

Very toxic polypeptide isolated mainly from AMANITA phalloides (Agaricaceae) or death cup; causes fatal liver, kidney and CNS damage in mushroom poisoning; used in the study of liver damage.

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Networked: 250 relevant articles (9 outcomes, 19 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Lu, Hong: 3 articles (12/2018 - 05/2008)
2.	Eshraghi, Adrien A: 3 articles (01/2010 - 11/2006)
3.	Chatterjee, Suvro: 2 articles (02/2018 - 03/2008)
4.	Kolluru, Gopi Krishna: 2 articles (02/2018 - 03/2008)
5.	Lin, Guiting: 2 articles (02/2015 - 10/2011)
6.	Lue, Tom F: 2 articles (02/2015 - 10/2011)
7.	Klaassen, Curtis D: 2 articles (01/2015 - 05/2008)
8.	Roy, Syamal: 2 articles (12/2014 - 06/2014)
9.	Bian, Jian-Chun: 2 articles (04/2014 - 06/2013)
10.	Fu, Ying-Xiao: 2 articles (04/2014 - 06/2013)

Related Diseases

1.	Cholestasis 01/15/1997 - "The biochemical studies on phalloidin-induced cholestasis in rats." 03/01/1996 - "To study the relationship between the dynamic actin web and bile secretion, we developed an acute model of cholestasis, using phalloidin, and examined sequential morphologic and biochemical events in rat liver. " 02/01/1996 - "In this study, the possible role of the hepatic microcirculation in phalloidin-induced cholestasis and hepatotoxicity was examined in isolated perfused rat livers (IPRL). " 08/15/2009 - "In BALU-1-treated animals, phalloidin-induced cholestasis was partially prevented. " 08/15/2009 - "Phalloidin causes severe liver damage characterized by marked cholestasis, which is due in part to irreversible polymerization of actin filaments. "
2.	Poisoning 06/01/1981 - "This protection against phalloidin poisoning is correlated with the rate of the toxin uptake by the liver. " 02/01/1987 - "This substance is, however, not useful for such studies since the mechanism of phalloidin poisoning is too specific for interpretation in the sense of general liver protection." 01/01/1973 - "[Proceedings: Electron microscopy studies of the liver-cell membrane in phalloidine poisoning]." 01/01/1967 - "[Electron microscopic studies on the mouse and rat livers in acute phalloidin poisoning]." 04/01/1990 - "Imperfection of methods used for laboratory diagnosis of such poisonings requires extensive experimental control using the designed method of liquid chromatography for amanitine and phalloidine assay in the cadaveric organs and tissues."
3.	Edema (Dropsy) 07/01/2009 - "Tissue buttons from 31 corneas with stromal edema and 8 normal corneas were fixed, and 3-mm(2) blocks were cut and stained with phalloidin, to visualize the cytoskeleton. " 10/01/1994 - "Treatment with phalloidin or HSD prevented edema formation and attenuated the reduction in the number of patent capillaries per fiber (1.62 +/- 0.2 and 1.71 +/- 0.2, respectively) induced by I-R, whereas administration of MAb IB4 after the formation of edema in reperfused muscles failed to limit capillary no-reflow (0.5 +/- 0.1 patent capillaries/fiber).(ABSTRACT TRUNCATED AT 250 WORDS)" 09/01/1989 - "When the same protocol was repeated with phalloidin present in the medium throughout the experiment, the structural integrity of the endothelial cells was completely preserved and pericyte shrinkage was abolished, but interstitial space edema still occurred. " 03/01/1991 - "Antamanide treatment was as effective in limiting lung and heart edema, but, in contrast to phalloidin, antamanide prevented kidney edema and did not lead to an alteration in the liver W/D. " 07/01/2002 - "This study shows that pretreatment with phalloidin, before the administration of dextran, abolishes the lowering of P(if) and edema formation, which is detected after i.v. injection of dextran alone."
4.	Hypertrophy 12/01/2020 - "In cultured H9c2 cells, phalloidin staining showed that DCAE relieved cellular hypertrophy (53% reduction). " 12/01/2020 - "Phalloidin staining was used to evaluate cellular hypertrophy. " 10/01/2008 - "Cardiomyocyte area, as an index of hypertrophy, was assayed by image analysis in phalloidin-stained HL-1 cells. " 07/01/2022 - "Cellular hypertrophy and fibrosis were assessed using phalloidin staining and western blotting. " 06/01/2002 - "The decrease in I(to1) in hypertrophied cells and the altered I(to1) responsiveness to phalloidin and cytochalasin D reflect modification of I(to1) channel function mediated, in part, through hypertrophy-altered cytoskeletal actin microfilament regulation of I(to1)."
5.	Hepatocellular Carcinoma (Hepatoma) 12/01/1978 - "When the same procedure was carried out with AS-30D hepatoma cells, and aliquots of the supernatants were tested with hepatocytes no marked decrease of the phalloidin response was seen. " 11/01/1996 - "Microinjection of C2 toxin or of phalloidin into hepatocyte-hepatoma hybrid cells had the same effects on actin synthesis as incubation with either toxin in the culture medium. " 12/01/1978 - "In contrast to normal liver cells, AS-30D hepatoma cells are insensitive to phalloidin. " 12/01/1978 - "A possible reason for the phalloidin tolerance of hepatoma cells." 12/01/1977 - "Different response to phalloidin in rats with various hepatomas."

Related Drugs and Biologics

1.	antamanide
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4.	Cholesterol
5.	Suspensions
6.	Maltose-Binding Proteins
7.	Lectins
8.	Phospholipids (Phosphatides)
9.	Nucleic Acids
10.	ursodoxicoltaurine

Related Therapies and Procedures

1.	Electrodes (Electrode)
2.	Ligation
3.	Lasers (Laser)
4.	Quantum Dots (Quantum Dot)
5.	Transjugular Intrahepatic Portasystemic Shunt