Perylene

A 20-carbon dibenz(de,kl)anthracene that can be viewed as a naphthalene fused to a phenalene or as dinaphthalene. It is used as fluorescent lipid probe in the cytochemistry of membranes and is a polycyclic hydrocarbon pollutant in soil and water. Derivatives may be carcinogenic.

Also Known As:

Networked: 61 relevant articles (1 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Yang, Zhen: 5 articles (01/2019 - 02/2015)
2.	Tuntiwechapikul, Wirote: 4 articles (11/2020 - 01/2012)
3.	Chen, Xiaoyuan: 4 articles (01/2019 - 01/2017)
4.	Song, Jibin: 4 articles (01/2019 - 01/2017)
5.	Fan, Quli: 4 articles (06/2018 - 02/2015)
6.	Huang, Wei: 4 articles (06/2018 - 02/2015)
7.	Lee, T Randall: 3 articles (11/2020 - 02/2013)
8.	Fan, Wenpei: 3 articles (01/2019 - 06/2018)
9.	Tang, Wei: 3 articles (01/2019 - 06/2018)
10.	Wang, Wei: 3 articles (01/2019 - 10/2017)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2017 - "Impact of Semiconducting Perylene Diimide Nanoparticle Size on Lymph Node Mapping and Cancer Imaging." 02/15/2013 - "The results of this study indicate that perylene derivatives warrant further consideration as effective agents for cancer therapy." 01/01/2012 - "This study might provide the foundation for the rational design and development of new perylene derivatives as effective anti-angiogenesis agents for cancer therapy." 01/01/2023 - "This work thus contributes one proof-of-concept demonstration of perylene as an integrated therapeutic platform for efficient immunogenic photochemotherapy against hypoxic tumors." 01/01/2023 - "Perylene-Mediated Electron Leakage in Respiratory Chain to Trigger Endogenous ROS Burst for Hypoxic Cancer Chemo-Immunotherapy."
2.	Hypoxia (Hypoxemia) 01/01/2023 - "Thus motivated, we herein present one perylene monoamide-based ROS supergenerator (PMIC-NC) that not only induces hypoxia-enhanced Type-I ROS burst aided by proton transients but also triggers Type-I/II ROS production by electron or energy transfer under near-infrared (NIR) light irradiation and also elicits a strong ICD effect. " 01/01/2022 - "Benefiting from the strong NIR absorption and good photothermal conversion performance of the in situ generated supramolecular perylene diimide radical anions, the hypoxia-induced PTT strategy exhibits excellent photothermal therapeutic efficiency as well as good specificity and biological safety. " 01/01/2022 - "Herein, we report a hypoxia-induced specific photothermal therapy (PTT) based on the photothermal agent of supramolecular perylene diimide radical anions. " 01/01/2022 - "In Situ Hypoxia-Induced Supramolecular Perylene Diimide Radical Anions in Tumors for Photothermal Therapy with Improved Specificity." 01/01/2023 - "Stirringly, PDIC-NI-induced ROS generation arouses enhanced mitochondrial oxidative stress and concurrently activates immunogenic cell death (ICD), which not only efficiently kills lung tumor cells but also reprograms immunosuppressive tumor microenvironment, including the cytokine secretion, dendritic cell maturation, as well as cytotoxic T lymphocytes activation, to inhibit the growth of xenografted and metastasis tumor, presenting a proof-of-concept demonstration of perylene that acts as an integrated therapeutic agent to well realize hypoxia-activated chemotherapy with ICD-induced immunotherapy on lung cancer."
3.	Lung Neoplasms (Lung Cancer) 02/15/2013 - "Telomere shortening and cell senescence induced by perylene derivatives in A549 human lung cancer cells." 12/01/2021 - "This study contributes a proof-of-concept demonstration of twisted perylene to well attain lung-specific distribution, and meanwhile achieves intensive lung cancer chemotherapy." 03/15/2022 - "Perylene diimide-POSS network for semi selective solid-phase microextraction of lung cancer biomarkers in exhaled breath." 01/01/2012 - "In this study, we compared two perylene monoimide derivatives, PM1 and PM2, with the well-studied perylene diimide derivative, PIPER, and the well-studied porphyrin derivative, TmPyP(4), with regard to G-quadruplex formation, G-quadruplex binding selectivity, and human VEGF gene silencing in A549 lung cancer cells. " 03/15/2022 - "Herein, we disclosed 3D network of POSS-naphthalene diimide (POSS-NDI) and perylene diimide (POSS-PDI) as extractive phases for analysis of lung cancer biomarkers with the capability of capturing different volatile organic compounds (VOCs). "
4.	Prostatic Neoplasms (Prostate Cancer) 11/24/2020 - "Superiority of an Asymmetric Perylene Diimide in Terms of Hydrosolubility, G-Quadruplex Binding, Cellular Uptake, and Telomerase Inhibition in Prostate Cancer Cells." 06/01/2019 - "Telomerase Inhibition, Telomere Shortening, and Cellular Uptake of the Perylene Derivatives PM2 and PIPER in Prostate Cancer Cells." 06/01/2019 - "In this study, we demonstrated that the perylene derivatives, PM2 and PIPER, could suppress human telomerase reverse transcriptase (hTERT) expression and telomerase activity in the short-term treatment of androgen-dependent prostate cancer cell line LNCaP and the androgen-independent prostate cancer cell line PC3 prostate cancer cells. "
5.	Photosensitivity Disorders (Photodermatitis) 01/01/2023 - "Our results indicated that photosensitization is the major mechanism underlying the anti-SARS-CoV-2 activity of perylene derivatives, with these compounds completely losing their antiviral potency under red light. " 01/01/1996 - "Photosensitization by anticancer agents 21: new perylene- and aminonaphthoquinones." 11/01/2013 - "The photosensitization effect of three perylene dye derivatives on titanium dioxide nanoparticles (TiO2 NPs) has been investigated. " 04/25/2013 - "We report on the photosensitization of titanium dioxide nanoparticles (TiO2 NPs) synthesized inside AOT (bis(2-ethylhexyl) sulfosuccinate sodium salt) reverse micelles following photoexcitation of perylene derivatives with dicarboxylate anchoring groups. "

Related Drugs and Biologics

1.	Anions
2.	Photosensitizing Agents (Photosensitizers)
3.	Telomerase (Telomerase Reverse Transcriptase)
4.	Proteins (Proteins, Gene)
5.	Ligands
6.	Carcinogens
7.	1-phenyl-3,3-dimethyltriazene (PDT)
8.	EMICORON
9.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
10.	Porphyrins

Related Therapies and Procedures

1.	Photothermal Therapy
2.	Therapeutics
3.	Drug Therapy (Chemotherapy)
4.	Precision Medicine
5.	Phototherapy (Light Therapy)