|1.||Moore, Thomas A: 2 articles (11/2013 - 04/2013)|
|2.||Palacios, Rodrigo E: 2 articles (11/2013 - 04/2013)|
|3.||Cosa, Gonzalo: 2 articles (11/2013 - 04/2013)|
|4.||Bergkamp, Jesse J: 2 articles (11/2013 - 04/2013)|
|5.||Tomlin, John: 2 articles (11/2013 - 04/2013)|
|6.||Moore, Ana L: 2 articles (11/2013 - 04/2013)|
|7.||Kodis, Gerdenis: 2 articles (11/2013 - 04/2013)|
|8.||Taka, Thanachai: 2 articles (02/2013 - 01/2012)|
|9.||Tuntiwechapikul, Wirote: 2 articles (02/2013 - 01/2012)|
|10.||Huang, Liming: 2 articles (02/2013 - 01/2012)|
02/15/2013 - "The results of this study indicate that perylene derivatives warrant further consideration as effective agents for cancer therapy."
01/01/2012 - "This study might provide the foundation for the rational design and development of new perylene derivatives as effective anti-angiogenesis agents for cancer therapy."
10/29/2014 - "To date, perylene derivatives have not been explored as DNA intercalator to inhibit cancer cells by intercalating into the base pairs of DNA. "
10/29/2014 - "A unique perylene-based DNA intercalator: localization in cell nuclei and inhibition of cancer cells and tumors."
12/01/2012 - "Notably, the biological effects of EMICORON are more potent than those of the previously described perylene derivative (PPL3C), and more interestingly, EMICORON appears to be detrimental to transformed and tumor cells, while normal fibroblasts expressing telomerase remain unaffected. "
|2.||Lung Neoplasms (Lung Cancer)
02/15/2013 - "Telomere shortening and cell senescence induced by perylene derivatives in A549 human lung cancer cells."
01/01/2012 - "In this study, we compared two perylene monoimide derivatives, PM1 and PM2, with the well-studied perylene diimide derivative, PIPER, and the well-studied porphyrin derivative, TmPyP(4), with regard to G-quadruplex formation, G-quadruplex binding selectivity, and human VEGF gene silencing in A549 lung cancer cells. "
01/01/2012 - "Incubating A549 lung cancer cells with these perylene derivatives, especially PM2, led to the reduction of both VEGF mRNA and VEGF protein. "
|3.||Photosensitivity Disorders (Photodermatitis)
01/01/1996 - "Photosensitization by anticancer agents 21: new perylene- and aminonaphthoquinones."
11/01/2013 - "The photosensitization effect of three perylene dye derivatives on titanium dioxide nanoparticles (TiO2 NPs) has been investigated. "
04/25/2013 - "We report on the photosensitization of titanium dioxide nanoparticles (TiO2 NPs) synthesized inside AOT (bis(2-ethylhexyl) sulfosuccinate sodium salt) reverse micelles following photoexcitation of perylene derivatives with dicarboxylate anchoring groups. "
|4.||Hepatocellular Carcinoma (Hepatoma)
08/01/1988 - "These results show that there was a correlation between the Ah receptor binding affinities of MC, B[a]P and perylene and their potencies as AHH inducers in Sprague-Dawley rats, and this corresponds to previous correlations for the induction of AHH in rat hepatoma H-4-II E cells in culture. "
08/01/1988 - "These data, coupled with the fact that the absence of the 4-5S binding protein in the -4S Sprague-Dawley rats did not affect AHH inducibility by MC, B[a]P or perylene, suggests that the 4-5S binding protein does not play a role in the transregulation of cytochrome P-4501A1 in the rat or rat hepatoma cells in culture."
02/01/1987 - "A comparison of the relative cytosolic Ah (9S) receptor binding affinities and aryl hydrocarbon hydroxylase (AHH) induction potencies of these hydrocarbons with their 4S protein binding affinities demonstrated the following: five compounds, namely 1,2,5,6-dibenz[a]-anthracene, 1,2,3,4-dibenz[a]anthracene, picene, benzo[a]pyrene and 3-methylcholanthrene exhibited high to moderate binding affinities for the 4S and 9S cytosolic proteins (EC50 values less than 10(-6) M) and induced AHH in rat hepatoma cells; three compounds, namely perylene, benzo[e]pyrene and benzo[g,h,i]perylene exhibited high affinities for the 4S binding protein (1.25 X 10(-7), 4.4 X 10(-8) and 2.9 X 10(-8) M, respectively) and low affinities (EC50 values greater than 10(-5) M) for the Ah receptor protein; moreover these three compounds did not induce AHH in rat hepatoma H-4-II E cells in culture. "
06/01/2002 - "Using this quantitative structure-activity relationship (QSAR) to calculate threshold values for the toxicity of the remaining nontoxic substances (benz[a]anthracene, chrysene, benzo[b]fluoranthene, benzo[k]fluoranthene, dibenz[a,h]anthracene, benzo[a]pyrene, perylene, and indeno[1,2,3-cd]pyrene), the absence of toxicity could, in most cases, be explained by a limited water solubility, indicating that these substances do act by narcosis as the mode of toxic action and that their toxicity is governed by concentrations in the pore-water. "
|1.||Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
|5.||Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)
|6.||Carrier Proteins (Binding Protein)
|7.||titanium dioxide (Titania)
|8.||Telomerase (Telomerase Reverse Transcriptase)
|9.||Photosensitizing Agents (Photosensitizers)