Perphenazine (Trilafon)

01/01/1991 - "The efficacy of the treatment with perphenazine correlated with the forms of schizophrenia, predominant syndromes in the disease clinical picture, and different stages of the process by the treatment commencement. "
05/01/1960 - "Perphenazine (fentazin) in the management of chronic schizophrenia."
05/01/2014 - "The objective of this study was to evaluate the impact of once- versus twice-daily dosing of perphenazine, which has a plasma half-life of 8-12 hours, on clinical outcomes in patients with schizophrenia. "
07/20/2005 - "Until well conducted and reported randomised trials are undertaken clinicians will be in doubt as to the effects of perphenazine depots and people with schizophrenia should exercise their own judgement or ask to be randomised."
01/01/2000 - "Until well conducted and reported randomised trials are undertaken clinicians will be in doubt as to the effects of perphenazine depots and people with schizophrenia should exercise their own judgement or ask to be randomised."

12/01/1997 - "On the day of surgery, both in and out-of hospital emesis were decreased by perphenazine. "
12/01/1997 - "There was less vomiting after perphenazine during the first 24 hr after surgery 42% (95% CI = 34%-50%) vs 57% (95% CI = 48%-66%, placebo), P < 0.01. "
01/01/1959 - "Value of perphenazine in control of postanaesthetic vomiting."
12/01/1997 - "The prophylactic administration of perphenazine decreases vomiting by children after tonsillectomy."
12/01/1997 - "To test the hypothesis that perphenazine decreases the incidence of vomiting by children after tonsillectomy. "

09/01/2021 - "Perphenazine-Associated Nausea: A Case of Protracted Withdrawal."
07/01/2020 - "Clinical experience and research data over these decades have shown perphenazine to be well-tolerated in psychiatric populations, in normals, and in non-psychiatric, medically ill populations for whom perphenazine is used to reduce nausea. "
11/01/1958 - "The effect of trilafon on postanesthetic nausea, retching and vomiting; a controlled study."
02/01/2011 - "Post-operative nausea and vomiting prevention with perphenazine: long overdue."
04/01/1959 - "Effect of trilafon on nausea and vomiting during labor."

08/01/1990 - "Although 36 of 66 patients showed resolution of psychosis, neither perphenazine nor N-dealkylated perphenazine levels were related to global response or to Brief Psychiatric Rating Scale (BPRS) totals. "
08/01/1990 - "Serum perphenazine concentrations and early resolution of psychosis were examined to determine if blood level monitoring could be used to maximize drug efficacy while limiting extrapyramidal side effects (EPS). "
01/01/1982 - "Dose-response relationships of perphenazine in the treatment of acute psychoses."
01/12/1970 - "[Comparison of triperidol with perphenazine in schizophrenic psychoses. "
08/01/1961 - "[Results of treatment with perphenazine in schizophrenic psychoses with reference to extrapyramidal symptomatology]."

12/01/2010 - "there is evidence that perphenazine is effective in the prevention of PONV in children and adults without serious adverse effects compared with placebo."
12/01/2010 - "randomised controlled trials investigating the efficacy of perphenazine in the prevention of PONV in comparison with any other drug or placebo were systematically searched in MEDLINE, EMBASE, CINAHL and the Cochrane Library. "
12/01/2010 - "Efficacy of perphenazine to prevent postoperative nausea and vomiting: a quantitative systematic review."
04/19/1958 - "Trials of perphenazine in the prevention of postoperative vomiting."
04/01/2014 - "Given the infrequent side effects, this single, low dose of perphenazine should be encouraged as a low-risk adjunct to any multimodal PONV prophylaxis regimen, based on the selection criteria described."