Periostitis

Inflammation of the periosteum. The condition is generally chronic, and is marked by tenderness and swelling of the bone and an aching pain. Acute periostitis is due to infection, is characterized by diffuse suppuration, severe pain, and constitutional symptoms, and usually results in necrosis. (Dorland, 27th ed)

Also Known As:

Networked: 201 relevant articles (13 outcomes, 8 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Abscess
2.	Osteomyelitis
3.	Periodontitis
4.	Pain (Aches)
5.	Gingivitis

Experts

1.	Malek, Alexandre E: 2 articles (10/2020 - 10/2020)
2.	Mulanovich, Victor E: 2 articles (10/2020 - 10/2020)
3.	Skaff, Yara: 2 articles (10/2020 - 10/2020)
4.	Junqueira, Rafael Binato: 2 articles (12/2019 - 09/2019)
5.	Rosado, Lucas de Paula Lopes: 2 articles (12/2019 - 09/2019)
6.	Verner, Francielle Silvestre: 2 articles (12/2019 - 09/2019)
7.	Fujita, Yasuyuki: 2 articles (02/2018 - 10/2015)
8.	Shimizu, Hiroshi: 2 articles (02/2018 - 10/2015)
9.	Adams, N: 2 articles (01/2018 - 01/2018)
10.	Cormican, S: 2 articles (01/2018 - 01/2018)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Periostitis:

1.	Voriconazole (Vfend)FDA LinkGeneric 09/01/2022 - "Early recognition of voriconazole-induced periostitis may result in both improved patient clinical outcomes and avoidance of unnecessary diagnostic testing." 10/01/2022 - "The purpose of this study was to assess the clinical characteristics, diagnosis and management of voriconazole-associated periostitis. " 09/01/2023 - "Voriconazole-Induced Periostitis: A Case Report." 01/01/2023 - "18F-NaF positron emission tomography/computed tomography in voriconazole-induced periostitis." 01/01/2023 - "The possible association between periostitis and voriconazole should attract sufficient attention in clinical practice. "
2.	Radioisotopes (Radionuclides)IBA 01/01/1980 - "Objective improvement in the radionuclide bone scan and radiographic periostitis was demonstrated after 6 months. " 03/01/1985 - "Histologically, the increased metabolic activity manifested on the radionuclide scan is due to a periostitis with new bone formation. " 06/01/1986 - "It is capable of excluding involvement of the medullary canal, and it is better than radionuclide studies for differentiating soft tissue infection with periostitis from osteomyelitis. " 12/01/2009 - "The diagnosis of periostitis was made by the documentation of bone pain, elevation of serum alkaline phosphatase and characteristic findings on radionuclide bone imaging in the absence of any identifiable rheumatologic disease. "
3.	ProstaglandinsIBA 11/01/1994 - "The periostitis improved on cessation of the prostaglandin infusion, and by 6 weeks after the cessation of the drug, the periostitis had decreased significantly. " 10/01/2017 - "Prostaglandin E1-Induced Periostitis and Reversibility with Discontinuation." 03/01/1995 - "Scintigraphic diagnosis of prostaglandin induced periostitis." 11/01/1994 - "Periostitis seemed more dependent on the duration of administration of the prostaglandin than on the dosage of prostaglandin administered. " 11/01/1994 - "Prostaglandin-induced neonatal periostitis."
4.	Alkaline PhosphataseIBA 09/18/2021 - "Patients typically present with diffuse bony pains associated with elevated serum alkaline phosphatase and plasma fluoride levels in conjunction with radiographic findings suggestive of periostitis. " 12/01/2013 - "However, upon further review, she had an elevated alkaline phosphatase and periostitis on her hip radiograph; voriconazole was held, and within 2 days she had marked improvement in her pain. " 03/01/2017 - "Periostitis is increasingly reported and should be considered in patients taking voriconazole who present with bone pain and/or alkaline phosphatase elevation." 12/01/2009 - "Awareness of this potential syndrome, which manifests as bone pain, elevated serum alkaline phosphatase and a bone scan suggestive of periostitis, is necessary in LT recipients on long-term voriconazole." 12/01/2009 - "The diagnosis of periostitis was made by the documentation of bone pain, elevation of serum alkaline phosphatase and characteristic findings on radionuclide bone imaging in the absence of any identifiable rheumatologic disease. "
5.	Infliximab (Remicade)FDA Link 09/01/2015 - "Childhood-onset psoriatic onycho-pachydermo-periostitis treated successfully with infliximab." 02/01/2018 - "Rapid response to clinical symptoms in early psoriatic onycho-pachydermo-periostitis treated with infliximab."
6.	ChitosanIBA 01/01/2005 - "[Clinical-microbiological evaluation of the efficacy of combined use of chitosan, low intensity laser radiation and photosensitizer in treatment of patients with acute suppurative maxillofacial periostitis]."
7.	Interleukin-17 (Interleukin 17)IBA 11/01/2021 - "Psoriatic onycho-pachydermo periostitis (POPP): a case report treated successfully with IL-17 blockade and a literature review on characteristics, pathogenesis, and treatment."
8.	Alendronate (Alendronate Sodium)FDA LinkGeneric 05/01/2007 - "Unexplained, transient inflammation seemed to cause her pericarditis, restrictive lung disease, and periostitis with accelerated skeletal turnover that responded well to antiinflammatory drugs and alendronate therapy."
9.	Photosensitizing Agents (Photosensitizers)IBA 01/01/2005 - "[Clinical-microbiological evaluation of the efficacy of combined use of chitosan, low intensity laser radiation and photosensitizer in treatment of patients with acute suppurative maxillofacial periostitis]."
10.	Phosphates (Orthophosphate)IBA 01/01/1865 - "The Efficacy of Phosphate of Lime in Periostitis."

Therapies and Procedures

1.	Therapeutics 02/01/2012 - "Residual joint swelling was found more commonly in RA patients than in PsA patients following TNFi therapy, whereas residual tender joints occurred more frequently in PsA; this may reflect enthesiopathy or periostitis." 01/01/2003 - "This indicated high efficiency of lymphotropic therapy of acute purulent maxillary periostitis for molars. " 01/01/2003 - "The structure of the gingival mucosa was studied by optic microscopy in patients with acute purulent odontogenic maxillary periostitis treated traditionally and receiving lymphotropic therapy. " 01/01/2003 - "[Lymphotropic therapy for acute purulent odontogenic jaw periostitis]." 01/01/2002 - "[Adsorption therapy for acute suppurative periostitis of the jaw]."
2.	Lasers (Laser) 01/01/2019 - "In our article, we described a clinical case of a patient with an acute periostitis of the maxilla with a comorbidity (primary immune thrombocytopenia, resistant form) who was treated using laser technology allowing us to provide good results: an intensive regeneration process and a decreased risk of developing infection complications and unpleasant signs for the patient, such as postoperative edema and intraoperative and postoperative pain syndrome." 01/01/2019 - "Use of Erbium Laser in the Treatment of a Patient with Acute Purulent Periostitis and a Resistant Form of Primary Immune Thrombocytopenia." 01/01/2005 - "[Clinical-microbiological evaluation of the efficacy of combined use of chitosan, low intensity laser radiation and photosensitizer in treatment of patients with acute suppurative maxillofacial periostitis]."
3.	Operative Surgical Procedures 08/10/2023 - "The diode laser was used in the oral cavity in the zone of inflammatory process (gingivitis, mucositis, periimplantitis, marginal periodontitis, abscess, periostitis, osteomyelitis etc.) in nine studies or in the zone before surgical procedures in one study; Conclusion: Based on the results of clinical studies, it can be stated that photodynamic therapy shows good results for operations performed in the oral cavity and pharynx." 08/01/1999 - "In 114 patients suffering from dental inflammatory diseases (periostitis, gingivitis, sinusitis, periodontitis etc.) and in 41 cases of dental surgical procedures (implantation, dentoalveolar surgery etc.) 3 x 300 mg/day clindamycin was applied during 7 days in the framework of GCP phases IV. In 150 cases (97%) the product proved to be effective and only in 2 cases a mild side effect was observed. "
4.	Semiconductor Lasers 08/10/2023 - "The diode laser was used in the oral cavity in the zone of inflammatory process (gingivitis, mucositis, periimplantitis, marginal periodontitis, abscess, periostitis, osteomyelitis etc.) in nine studies or in the zone before surgical procedures in one study; Conclusion: Based on the results of clinical studies, it can be stated that photodynamic therapy shows good results for operations performed in the oral cavity and pharynx."
5.	Photochemotherapy (Photodynamic Therapy) 08/10/2023 - "The diode laser was used in the oral cavity in the zone of inflammatory process (gingivitis, mucositis, periimplantitis, marginal periodontitis, abscess, periostitis, osteomyelitis etc.) in nine studies or in the zone before surgical procedures in one study; Conclusion: Based on the results of clinical studies, it can be stated that photodynamic therapy shows good results for operations performed in the oral cavity and pharynx."