|1.||Dental Caries (White Spot)
|4.||Alveolar Bone Loss
|1.||Pradeep, A R: 23 articles (05/2013 - 08/2006)|
|2.||Offenbacher, Steven: 20 articles (12/2013 - 12/2002)|
|3.||Miyazaki, Hideo: 19 articles (08/2015 - 01/2002)|
|4.||Grenier, Daniel: 18 articles (08/2015 - 02/2005)|
|5.||Seymour, G J: 17 articles (12/2014 - 04/2001)|
|6.||Yoshihara, Akihiro: 16 articles (08/2015 - 12/2002)|
|7.||Kim, Sung-Jo: 15 articles (12/2015 - 12/2004)|
|8.||Emingil, Gülnur: 15 articles (01/2015 - 01/2004)|
|9.||Sorsa, Timo: 13 articles (02/2016 - 01/2004)|
|10.||Giannobile, William V: 13 articles (02/2014 - 01/2003)|
|1.||Metronidazole (Metric)FDA LinkGeneric
11/01/1986 - "The results showed a significantly greater reduction in the mean probing depth of pockets with the use of metronidazole, but this reduction was apparent only in subjects with severe periodontal disease (PI = 4.0-6.0). "
10/01/1990 - "In the present study, we describe the usefulness of the BANA test at various stages of a clinical trial of the efficacy of metronidazole in the treatment of periodontal disease. "
01/01/2004 - "The aim of this study was to evaluate the microbial outcome in patients with recurrent periodontal disease following treatment with 25% metronidazole gel using the polymerase chain reaction (PCR). "
03/01/2003 - "This study showed that local treatment with 25% metronidazole gel did not seem to influence the clinical healing in this group of subjects with recurrent periodontal disease."
03/01/2003 - "The aim of this study was to evaluate the clinical outcome in patients with recurrent periodontal disease following treatment with 25% metronidazole gel. "
|2.||Anti-Bacterial Agents (Antibiotics)IBA
01/01/2014 - "[Antimicrobial efficacy of systemic antibiotics of different groups in the complex treatment of patients with chronic periodontal disease]."
09/01/2015 - "Randomised controlled trials (RCTs) in adults over the age of 18 with diabetes and periodontal disease undergoing non-surgical periodontal treatment with or without adjunctive antibiotics, with a follow up period of at least three months were considered.Data"
12/01/2012 - "Examination of bacterial detection frequency and loads in Chinese adults may assist microbial studies of periodontal disease and will shed light on periodontal disease diagnosis and treatment using antibiotics in the Chinese population."
08/01/1993 - "Clinical studies do, however, support the use of antibiotics in the treatment of specific periodontal diseases."
09/01/2015 - "Therapists should consider the patient's overall risk for periodontal disease when deciding for or against adjunctive antibiotics prescription."
|3.||Tetracycline (Achromycin)FDA LinkGeneric
01/01/1994 - "These results indicate that use of tetracycline fiber plus SRP clearly reduced the clinical signs of periodontal disease and maintained or improved attachment for up to 24 months in sites previously refractory to treatment."
07/01/1991 - "The safety and efficacy of periodontal disease treatment by intrapocket placement of tetracycline (TC) fibers was investigated in a 60-day multicenter study conducted by selecting 4 sites in each subject with 6-10 mm pockets that bled on probing. "
12/01/2001 - "This study examined the creep behavior and oscillatory and flow properties of tetracycline-containing, bioadhesive semisolid formulations, designed for localized treatment of periodontal disease. "
11/01/1996 - "This study examined the mechanical characteristics and release of tetracycline from bioadhesive, semi-solid systems which were designed for the treatment of periodontal diseases. "
12/01/1989 - "The purpose of this study was to evaluate the clinical application of strips containing 10% Tetracycline (TC) in periodontal disease. "
|4.||Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
04/01/1996 - "However until more data are available, NSAIDs should not be used in the management of chronic periodontal diseases, there being no specific agent(s) or regimen established for use. "
01/01/1993 - "In addition to recent advances in the identification and control of etiologic bacteria, investigators have indicated promising results using nonsteroidal antiinflammatory drugs (NSAIDs) as inhibitors of the inflammatory destruction in periodontal disease. "
12/01/2003 - "3. NSAIDS show promise in their ability to slow periodontal disease. "
01/01/1998 - "[The comparative efficacy of nonsteroidal anti-inflammatory agents in the combined treatment of periodontal diseases]."
12/01/1997 - "These studies indicate that NSAIDs have the ability to alter or control the progression of periodontal disease. "
|5.||Interleukin-6 (Interleukin 6)IBA
04/15/2014 - "Host modulatory agents targeting at inhibiting IL-6, therefore, appear to be beneficial in slowing the progression of periodontal disease and potentially reducing destructive aspects of the host response. "
01/01/2015 - "The results of this study showed that CRP and IL-6 are associated with periodontal diseases in atherosclerotic patients. "
09/01/2014 - "The purpose of the present study is to evaluate YKL-40 and IL-6 levels in gingival crevicular fluid (GCF) and serum of patients with periodontal disease and healthy individuals. "
10/10/2011 - "Detection and characterization of interleukin-6 gene variants in Canis familiaris: association studies with periodontal disease."
03/01/2010 - "The results of this study showed a significant difference in the allele and genotype frequencies of IL-6 gene polymorphism between patients with periodontal disease and controls. "
04/01/2014 - "Titers of serum antibodies autoreactive with CD24 peptide correlated with reduced severity of periodontal disease. "
08/19/2011 - "Titers of serum antibodies auto-reactive with CD24 peptide correlated with reduced severity of periodontal disease. "
05/01/2012 - "This study provides initial data that demonstrate elevated antibodies to periodontal disease bacteria in subjects years before cognitive impairment and suggests that periodontal disease could potentially contribute to the risk of AD onset/progression. "
12/01/2003 - "Studies that used MMP tissue inhibitors as diagnostic or prognostic indicators of periodontal disease or that evaluated short-term systemic antibodies or locally delivered levels of drugs with antiproteinase activity were excluded. "
11/01/1984 - "A study of antibodies and opsonic activity in human crevicular fluid in relation to periodontal disease."
10/01/2015 - "Chlorhexidine mouthwash has earned eponym of gold standard to treat and/or prevent periodontal diseases. "
01/01/1997 - "[The treatment of periodontal diseases using Diplen-Denta films with chlorhexidine (a clinico-laboratory study)]."
07/01/1990 - "Previous studies have demonstrated the advantages of the local sustained release of chlorhexidine from nondegradable devices in the treatment of periodontal diseases. "
04/01/1990 - "An in vivo study of neutrophil locomotion in relation to periodontal disease status and local chlorhexidine."
03/01/2014 - "hystrix leaf oil could be used as a natural active compound or in combination with chlorhexidine in mouthwash preparations to prevent the growth of bacteria associated with periodontal diseases and biofilm formation."
|8.||Doxycycline (Vibramycin)FDA LinkGeneric
06/01/1991 - "Therefore, it is suggested that doxycycline may be beneficial for the treatment of periodontal disease as an adjunct to traditional therapeutic methods."
12/01/2004 - "Efficacy of subantimicrobial-dose doxycycline in the treatment of periodontal diseases: a critical evaluation."
02/01/2011 - "Clinical studies on the management of periodontal diseases utilizing subantimicrobial dose doxycycline (SDD)."
05/28/2010 - "Despite the high therapeutic potential of MMP inhibitors (MMPIs), all clinical trials have failed to date, except for doxycycline for periodontal disease. "
05/01/1991 - "In this study, substantivity of topically applied doxycycline hydrochloride on root surfaces obtained from patients with periodontal disease was studied in vitro. "
10/01/2015 - "The antibacterial and antioxidant properties of green tea were found to be beneficial in the treatment of gingival and periodontal diseases. "
05/01/2013 - "Extracts from green tea, white tea, oolong tea, and black tea show promise for controlling periodontal disease by their capacity to interfere with P. "
01/01/2015 - "Human studies reveal that the prognosis of periodontal disease is better when the green tea catechins are used via local drug delivery. "
01/01/2015 - "Therefore, green tea represents a potential therapeutic agent for the treatment of diabetes-related periodontal disease."
05/01/2013 - "Antibacterial, antiadherence, antiprotease, and anti-inflammatory activities of various tea extracts: potential benefits for periodontal diseases."
|10.||ruberythric acid (AlP)IBA
07/01/2012 - "The obtained results showed statistically significant increased activity of AST, ALT, GGT, ALP, and ACP in the saliva from patients with periodontal disease, in relation to the control group. "
01/01/2012 - "The obtained results showed statistically significant increased activities of ALP and ACP in saliva from patients with periodontal disease in relation to control group. "
01/01/2012 - "In this prospective analytical study, we examined the activities of salivary ALP and ACP in patients with periodontal disease, before and after periodontal treatment. "
01/01/2006 - "More studies are necessary to evaluate which specific clinical, microbiological and histological characteristics of periodontal disease are associated with elevated levels of AST and ALP in saliva."
01/01/2012 - "The assessment of level of periodontal disease and effect of mechanical plaque control on the progression and regression of the disease can be evaluated precisely by the corresponding GCF ALP levels. "
|1.||Oral Hygiene (Dental Hygiene)
05/01/1980 - "With an optimal level of oral hygiene, periodontal disease can be cured and further destruction of the periodontal tissues avoided irrespective of the surgical technique utilized for pocket elimination. "
02/01/2000 - "Periodontal disease prevalence was high but would respond to improved oral hygiene. "
06/01/1998 - "Improved diagnostics based on more precise periodontal disease classification, simplification of mechanical oral hygiene equipment and procedures, and the development of conventional and non-conventional chemical and physical adjuncts may be expected to reduce the rate of common periodontal disease advance, resulting in less complex treatments, and more of the latter coming to lie within the competence of the generalist and the hygienist working together. "
01/01/2012 - "To establish whether CD4+ T cell counts or oral hygiene plays a greater role in producing BANA-positive results in HIV-associated periodontal disease. "
04/01/2015 - "Managing oral hygiene as a risk factor for periodontal disease: a systematic review of psychological approaches to behaviour change for improved plaque control in periodontal management."
12/01/2003 - "Although mechanical non-surgical therapy (scaling and root planing) is the most common means of initial treatment of periodontal diseases, the relative clinical efficacy of various methods, including manual versus machine-driven, with or without adjunctive agents, has not been determined. "
11/01/1991 - "By common methods like scaling and root planing, flap procedures or surgical furcation treatment, a successful therapy of periodontal disease is possible in about 90% of the cases. "
06/01/2013 - "The aim of the study was to assess the immunomodulatory effects of the herbal immunomodulator Septilin® (Himalaya Drug Company, Bangalore, India) when used as an adjunct to scaling and root planing in chronic periodontal disease. "
03/01/2013 - "This study was conducted to verify whether periodontal disease in a deep intrabony defect and complex therapy, including aggressive root planing such as in periodontal regeneration, have an influence on tooth vitality. "
01/01/2010 - "Randomised controlled trials including pregnant women with documented periodontal disease randomised to either treatment with scaling and root planing or no treatment. "
|3.||Drug Therapy (Chemotherapy)
04/01/1996 - "Chemotherapy has an important place in the management of chronic periodontal diseases but routine use must be considered as an over prescription of these valuable agents."
03/01/1997 - "The approval of pharmaceutical products for the treatment and/or prevention of periodontal diseases requires presentation of evidence that supports the safety and efficacy of the particular drug therapy in question. "
09/01/1987 - "This study characterized the subgingival microbial flora associated with 27 acute exacerbations of preexistent periodontal disease in 24 patients with chemotherapy-induced myelosuppression. "
12/01/2009 - "The SA-based PAE/antimicrobial blends are being investigated as an improvement on current localized drug therapies used to treat periodontal disease."
11/01/2005 - "[Treatment of periodontal disease: Part VI. Concepts of periodontal drug therapy]."
01/01/2013 - "Treatment of periodontal diseases by nonsurgical debridement has been considered as a gold standard procedure. "
01/01/2013 - "The aim of this study was to investigate the effect of antioxidant therapy on the progression of periodontal disease as monotherapy and/or as an adjunct to nonsurgical debridement. "
02/01/2015 - "Periodontal therapies aimed at altering the progression of periodontal diseases must include meticulous mechanical debridement during both the non-surgical and the surgical phases of periodontal treatment. "
08/01/2014 - "Periodontal disease is a common disease of dogs and cats often requiring antimicrobial treatment as an adjunct to mechanical debridement. "
03/01/2014 - "Systemic antibiotic treatment has emerged as a powerful adjunct to conventional mechanical debridement for therapeutic management of the periodontal diseases. "
01/01/2001 - "This method will be helpful in the diagnosis of periodontal diseases, monitoring of the pathological process after treatment, and in solution of theoretical problems, e.g. "
07/01/2013 - "This suggests that MMP-3 levels in GCF increases proportionally with the progression of periodontal disease and decreases after treatment. "
10/01/2012 - "This suggests that MMP-3 levels in GCF increases proportionally with the progression of periodontal disease and decreases after treatment. "
01/01/2012 - "The phagocytic index values from subjects with periodontal disease after treatment achieved those found in the control group."
01/01/2012 - "The adverse clinical outcomes observed in presence of these microorganisms could have implications in the pathogenesis of periodontal disease and a possible impact on outcomes after treatment."