Peptides (Polypeptides)

Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are considered to be larger versions of peptides that can form into complex structures such as ENZYMES and RECEPTORS.

Also Known As:

Networked: 82426 relevant articles (3780 outcomes, 8922 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Itoh, Kyogo: 155 articles (06/2022 - 01/2002)
2.	Wang, Wei: 98 articles (10/2022 - 05/2003)
3.	Yamada, Akira: 95 articles (08/2021 - 09/2002)
4.	Wang, Jing: 92 articles (05/2022 - 09/2003)
5.	Chen, Xiaoyuan: 89 articles (01/2022 - 01/2004)
6.	Zhang, Wei: 88 articles (09/2022 - 09/2003)
7.	Mischak, Harald: 82 articles (04/2022 - 09/2003)
8.	Wang, Ying: 81 articles (07/2022 - 04/2003)
9.	Sette, Alessandro: 80 articles (06/2022 - 05/2002)
10.	Sugiyama, Haruo: 78 articles (02/2022 - 08/2002)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2016 - "While highly effective for slowing cancer progression in principle, the c-Myc inhibitor peptide H1-S6A,F8A (H1) has not performed well in tumor studies, in part because it does not pass efficiently through the nuclear envelope. " 05/01/2023 - "Non-genetic decoration of Th9 cells with tumor-targeting peptide screened from phage display not only allowed precise targeted ACT against highly heterogeneous solid tumors but also substantially enhanced infiltration of CD8+ T cells, which led to improved antitumor outcomes. " 01/01/2020 - "Peptides with enhanced hydrophobicity showed increased toxicity, but in most cases their selectivity toward tumor cells also improved. " 06/13/2018 - "The results indicated that most stapled peptide analogues possessed improved activities against a series of tumor cells; in particular, the bicyclic stapled peptide H-10 showed promising prospects for novel anti-tumor drug development. " 01/01/2017 - "We identified a peptide designated as Linear TT1 (Lin TT1) (sequence: AKRGARSTA) as most effective in causing tumor homing and penetration of the nanosystem. "
2.	Infections 02/16/2022 - "Treatment with the most-promising myristoylated peptide was effective in counteracting the infection from C. " 02/01/2019 - "Associated vaccination of mice using LAIV and GBS peptide was the most effective against sub-lethal infection with A/H7N9 influenza virus and against lethal challenge with A/H1N1pdm virus at day 5 after immunization. " 01/01/2013 - "Besides the native peptides, several shortened, modified, or even artificial sequences were highly effective in different murine infection models. " 11/01/2011 - "External use of the peptide ctriporin dramatically decreased the bacterial counts and cured skin infections in mice. " 05/01/2003 - "After the first day of infection, the amount of SPI1 polypeptide was dramatically reduced in response to either of the pathogens, but not in response to the ectomycorrhizal fungus Laccaria bicolor. "
3.	Inflammation (Inflammations) 06/01/2011 - "Targeting JNK with the peptide inhibitor D-JNKi dramatically reduced inflammation and joint destruction in WT mice. " 01/01/2022 - "TREM-1 is an important eCIRP receptor in the inflammatory response of hepatic I/R, and deficiency of TREM-1 via knockout gene or peptide inhibition attenuated liver injury and inflammation, and improved survival. " 01/08/2009 - "Moreover, non-peptide antagonists were very effective in reducing skin inflammation when topically applied, thereby suggesting that they could be useful tools in the treatment of some skin inflammatory diseases." 10/01/2002 - "Engagement of the LXR by LX generated during cell-cell interactions in inflammation and by endogenous LXR peptide agonists released from distressed cells may be an important stimulus for clearance of apoptotic cells and may be amenable to pharmacologic mimicry for therapeutic gain." 01/01/2023 - "Peptides can provide the versatility required for the successful delivery of drugs due to their structural diversity and their capability to lead drugs at the site of inflammation while maintaining optimum therapeutic efficacy. "
4.	Alzheimer Disease (Alzheimer's Disease) 12/11/2018 - "Serotoninergic activation which decreases brain Aβ peptides is considered beneficial in mouse models for Alzheimer's disease (AD), but the mechanisms involved remain unclear. " 05/01/2023 - "Exploring the therapeutic efficacy of Chlorella pyrenoidosa peptides in ameliorating Alzheimer's disease." 03/01/2004 - "These promising results indicate that these peptide molecules could be a starting point for the development of potential therapeutic compounds for the treatment of Alzheimer's disease." 01/01/2018 - "Synergistic Protective Effects of Mitochondrial Division Inhibitor 1 and Mitochondria-Targeted Small Peptide SS31 in Alzheimer's Disease." 10/01/2007 - "Blood-based tests for the differential diagnosis of Alzheimer's disease (AD) are under intensive investigation and have shown promising results with regard to Abeta40 and Abeta42 peptide species in incipient AD. "
5.	Melanoma (Melanoma, Malignant) 08/01/2001 - "There are several reports of successful induction of HLA class I-restricted antitumor CTLs using MAGE peptides, and some clinical trials with these immunogenic peptides were reported as effective for some patients with malignant melanoma. " 11/17/2022 - "The peptide RDP22 has clearly shown high potential against the melanoma cell line MUG-Mel2 in vitro and in vivo." 09/01/2015 - "Helper peptide vaccination is associated with improved overall survival among patients with metastatic melanoma. " 09/01/2015 - "Vaccination with Melanoma Helper Peptides Induces Antibody Responses Associated with Improved Overall Survival." 11/30/2001 - "Of major interest, we determined that freshly-isolated PBMC frequencies of Th1-type CD4+ T recognizing these peptides are frequently elevated in HLA-DR4+ melanoma patients (but not normal donors) that are currently disease-free as a result of therapeutic intervention. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Peptides (Polypeptides)
3.	Vaccines
4.	Antigens
5.	Epitopes
6.	Amyloid (Amyloid Fibrils)
7.	Antibodies
8.	Ligands
9.	Amino Acids
10.	Glucose (Dextrose)

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy
3.	Drug Therapy (Chemotherapy)
4.	Injections
5.	Precision Medicine