Peptide Synthases

Ligases that catalyze the joining of adjacent AMINO ACIDS by the formation of carbon-nitrogen bonds between their carboxylic acid groups and amine groups.

Also Known As:

Networked: 10 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Arp, Johannes: 1 article (12/2019)
2.	García-Altares, María: 1 article (12/2019)
3.	Götze, Sebastian: 1 article (12/2019)
4.	Günther, Markus: 1 article (12/2019)
5.	Klapper, Martin: 1 article (12/2019)
6.	Kries, Hajo: 1 article (12/2019)
7.	Lackner, Gerald: 1 article (12/2019)
8.	Stallforth, Pierre: 1 article (12/2019)
9.	Willing, Karsten: 1 article (12/2019)
10.	Zhang, Shuaibing: 1 article (12/2019)

Related Diseases

1.	Infections 10/01/2015 - "The ΔCsVosA mutants showed significant reduction in virulence on susceptible barley plants and the two genes for nonribosomal peptide synthetases (NRPSs) involved in virulence during host infection were down-regulated in ΔCsVosA, suggesting that CsVosA may affect virulence of the fungus by regulating the expression of the genes for NRPSs, as well as other genes directly or indirectly involved in virulence. "
2.	Neoplasms (Cancer) 08/15/2000 - "We have previously proposed that the BlmIV and BlmIII non-ribosomal peptide synthetases are involved in the formation of the bithiazole moiety of the anti-tumor drug bleomycin in Streptomyces verticillus ATCC15003. " 12/28/2019 - "Modular biosynthetic machineries such as polyketide synthases (PKSs) or nonribosomal peptide synthetases (NRPSs) give rise to a vast structural diversity of bioactive metabolites indispensable in the treatment of cancer or infectious diseases. " 10/01/2019 - "Non-ribosomal peptide synthetases (NRPSs) are modular enzymatic machines that catalyze the ribosome-independent production of structurally complex small peptides, many of which have important clinical applications as antibiotics, antifungals and anti-cancer agents. " 06/01/2015 - "Nonribosomal peptide synthetases are large, multi-domain enzymes that produce peptide molecules with important biological activity such as antibiotic, antiviral, anti-tumor, siderophore and immunosuppressant action. "
3.	Starvation 01/01/2018 - "BPS: bathophenanthrolinedisulfonate; BSA: bovine serum albumin; CFU: colony forming unit; -Fe: iron starvation; +Fe: iron sufficiency; hFe: high iron; NRPSs: nonribosomal peptide synthetases; PKSs: polyketide synthaseses; wt: wild type."
4.	Necrosis 07/01/2013 - "An Sfp-type PPTase and associated polyketide and nonribosomal peptide synthases in Agrobacterium vitis are essential for induction of tobacco hypersensitive response and grape necrosis."
5.	Mycoses (Diseases, Fungus) 11/01/2019 - "Here, metagenomics and network inference show that fungal infection of plant roots enriched for Chitinophagaceae and Flavobacteriaceae in the root endosphere and for chitinase genes and various unknown biosynthetic gene clusters encoding the production of nonribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs). "

Related Drugs and Biologics

1.	Polyketide Synthases
2.	Polyketides
3.	Peptides (Polypeptides)
4.	Anti-Bacterial Agents (Antibiotics)
5.	Siderophores
6.	Terpenes (Terpenoids)
7.	Bovine Serum Albumin
8.	Ligases (Synthetase)
9.	Iron
10.	Immunosuppressive Agents (Immunosuppressants)