Pepsinogens

Proenzymes secreted by chief cells, mucous neck cells, and pyloric gland cells, which are converted into pepsin in the presence of gastric acid or pepsin itself. (Dorland, 28th ed) In humans there are 2 related pepsinogen systems: PEPSINOGEN A (formerly pepsinogen I or pepsinogen) and PEPSINOGEN C (formerly pepsinogen II or progastricsin). Pepsinogen B is the name of a pepsinogen from pigs.

Also Known As:

Pepsinogen B

Networked: 213 relevant articles (2 outcomes, 29 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Muhsen, Khitam: 7 articles (01/2021 - 08/2017)
2.	Fukuda, Shinsaku: 6 articles (01/2020 - 04/2009)
3.	Shimoyama, Tadashi: 6 articles (01/2020 - 04/2009)
4.	Hamajima, Nobuyuki: 6 articles (04/2011 - 01/2006)
5.	Goto, Yasuyuki: 5 articles (04/2011 - 01/2006)
6.	Leja, Marcis: 4 articles (01/2020 - 12/2012)
7.	Nakaji, Shigeyuki: 4 articles (01/2020 - 04/2009)
8.	Naito, Mariko: 4 articles (04/2011 - 01/2006)
9.	Herrero, Rolando: 3 articles (01/2022 - 12/2019)
10.	Park, Jin Young: 3 articles (01/2022 - 12/2019)

Related Diseases

1.	Atrophic Gastritis 01/01/2020 - "The presence and severity of atrophic gastritis were defined by serum levels of pepsinogens. " 12/04/2018 - "pylori sero-prevalence and serum pepsinogens (PGs), as non-invasive markers of atrophic gastritis, with haemoglobin levels. " 01/01/2018 - "The presence and the severity of atrophic gastritis were defined by the serum level of serum pepsinogens. " 07/20/2017 - "Pepsinogens play an important role in the identification of patients with atrophic gastritis and severe AG. " 09/01/2006 - "Relationship between Helicobacter pylori status and serum pepsinogens as serologic markers in atrophic gastritis."
2.	Gastritis 10/01/2006 - "We sought to study the relationship between serum pepsinogens and different histopathologic features of Helicobacter pylori-related chronic gastritis. " 09/01/2001 - "The aim of this study was to evaluate the diagnostic potential of serum pepsinogens I and II in predicting the topography and severity of gastritis in H. " 09/01/2001 - "It has long been recognised that specific patterns of gastritis are linked with different gastroduodenal diseases and that serum pepsinogens vary with the histological state of the gastric mucosa. " 09/01/2001 - "Variation in serum pepsinogens with severity and topography of Helicobacter pylori-associated chronic gastritis in dyspeptic patients referred for endoscopy." 07/01/1995 - "Extreme (low/high) levels of pepsinogens A and C, indicative of chronic gastritis, were found in 24 (5.7%) and 61 (14.5%) of the participants, respectively. "
3.	Atrophy 12/01/2019 - "There is so far limited evidence on the performance of pepsinogens for atrophy detection in Central Asia. " 08/01/2017 - "Detection of gastric atrophy by circulating pepsinogens: A comparison of three assays." 04/01/2011 - "Serum pepsinogens were measured to evaluate gastric atrophy. " 01/01/2009 - "Serum pepsinogens were measured to evaluate gastric atrophy. " 04/01/2008 - "Gastric atrophy was evaluated with serum pepsinogens (PG1<70 ng/ml and PG1/PG2<3). "
4.	Stomach Neoplasms (Stomach Cancer) 01/01/2021 - "Pepsinogens (PGs) can be used for gastric cancer (GC) screening, but the cutoff levels vary among studies, and PG levels are influenced by numerous factors. " 08/04/2000 - "Furthermore, no studies have directly examined whether the screening with serum pepsinogens reduced gastric cancer mortality. " 12/01/1995 - "The aim of this study was to estimate the validity of mass screening for gastric cancer using serum pepsinogens (PG test). " 01/01/1988 - "[Immunomorphologic study of pepsinogens in stomach cancer]." 06/01/1976 - "Immunochemical study and cellular localization of human pepsinogens during ontogenesis and in gastric cancers."
5.	Infections 04/01/2006 - "We explored the use of serum pepsinogens (PG) for diagnosis of acute infection in patients following H. " 09/01/2000 - "pylori infection, and serum pepsinogens were used to define of CAG. " 05/01/2000 - "Long-term effect of Helicobacter pylori infection on serum pepsinogens." 01/01/1999 - "Patients with impaired renal function have been known to have elevated concentrations of serum pepsinogens, which are raised by Helicobacter pylori infection of the stomach. " 04/01/1992 - "Influence of age and Helicobacter pylori infection on serum pepsinogens in healthy blood transfusion donors."

Related Drugs and Biologics

1.	gastrin 17 (G 17)
2.	Gastrins
3.	Biomarkers (Surrogate Marker)
4.	Antibodies
5.	Pepsinogen A (Pepsinogen)
6.	Immunoglobulin G (IgG)
7.	Pepsinogen C
8.	Omeprazole (Prilosec)
9.	beta Carotene (Betacarotene)
10.	Mucins

Related Therapies and Procedures

1.	Therapeutics
2.	Proximal Gastric Vagotomy
3.	Gastrectomy
4.	Vagotomy
5.	Gastroenterostomy