|1.||Johnston, Nikki: 19 articles (12/2015 - 12/2004)|
|2.||Dettmar, Peter W: 11 articles (10/2013 - 02/2002)|
|3.||He, Zhaoping: 7 articles (04/2015 - 09/2006)|
|4.||Samuels, Tina L: 6 articles (12/2015 - 11/2009)|
|5.||Soundar, Sam: 6 articles (04/2015 - 09/2006)|
|6.||Sifrim, Daniel: 5 articles (03/2015 - 04/2008)|
|7.||Takeuchi, Koji: 5 articles (01/2014 - 01/2005)|
|8.||Konturek, S J: 5 articles (02/2011 - 01/2000)|
|9.||Goel, R K: 5 articles (04/2009 - 10/2000)|
|10.||O'Reilly, Robert C: 4 articles (04/2015 - 07/2007)|
|1.||Duodenal Ulcer (Curling's Ulcer)
01/01/1978 - "[Studies on pepsin and acid secretion following various operations for gastric and duodenal ulcer (author's transl)]."
09/01/1966 - "[Study of the acid-pepsin correlation of gastric secretion in patients with duodenal ulcer]."
04/01/1997 - "The pathogenesis of duodenal ulcer appears to be multifactorial, involving an imbalance between "aggressive" (e.g., acid and pepsin) and "defensive" (e.g., prostaglandin production, mucus/mucosal barrier, bicarbonate production, blood flow, cell regeneration) factors. "
02/01/1995 - "Since William Beaumont's classic description of gastric physiology in 1847, the focus of clinical practice and basic research concerning gastric and duodenal ulcers has centered on the secretion of acid and pepsin. "
12/01/1994 - "High basal pepsin output may play an important role in the pathogenesis of duodenal ulcers in the Chinese."
|2.||Gastroesophageal Reflux (GERD)
03/01/1999 - "Etiologically, gastroesophageal reflux disease (GERD) can be regarded as motility disorder: Although blocking acid is effective in the treatment of GERD, it does not overcome the underlying pathologic factors that allow acid, pepsin, and bile to reflux into the esophagus. "
06/01/2015 - "This study aimed to investigate pepsin as a marker of extra-oesophageal reflux disease by examining its presence in tracheal aspirates and correlating it with macroscopic changes on laryngobronchoscopy, along with the results of standard tests for gastro-oesophageal reflux disease and clinical features. "
10/01/2011 - "These findings potentially affect previous study results that used an enzymatic pepsin detection assay to evaluate for and associate gastroesophageal reflux disease with other morbidities."
10/01/2009 - "The purpose of this study was to investigate if pepsin measured in sputum is a useful marker of pulmonary aspiration secondary to gastroesophageal reflux (GER) in children. "
10/01/1999 - "The most likely mechanism for laryngeal injury and symptoms is secondary to direct acid and pepsin contact, although studies concerning the cause and effect between gastroesophageal reflux disease and laryngeal disorders are conflicting. "
|3.||Peptic Esophagitis (Reflux Esophagitis)
11/01/2001 - "These studies suggest that acidified pepsin plays a key role in the development of reflux esophagitis by producing an early irreversible lesion that results in an increase in paracellular permeability, which indirect evidence suggests is due to damage to the junctional complex. "
02/01/2006 - "It is assumed that pepsin plays a major pathogenic role in the development of acid reflux esophagitis."
02/01/2006 - "Essential role of pepsin in pathogenesis of acid reflux esophagitis in rats."
11/01/2003 - "The pathophysiology of reflux esophagitis involves contact of the esophageal epithelium with acid-pepsin in the refluxate. "
01/01/1999 - "Different and highly reproducible esophageal mucosal lesions mimicking human reflux esophagitis can be induced in rabbits with repetitive acid and pepsin exposure."
|4.||Peptic Ulcer (Peptic Ulcers)
09/03/1990 - "At present, the therapeutic possibilities seem to be restricted and nothing indicates that stimulation of the defensive factors, only, is more effective in the treatment of peptic ulcer than inhibition of aggressive factors as acid and pepsin."
06/01/1991 - "This technique will allow detailed clinical studies which may provide insight into the question whether or not there are specific forms of pepsin that are associated with peptic ulcer."
06/01/1991 - "Studies on the role of pepsin in the pathogenesis of peptic ulcer are hampered by lack of suitable methods for the separation, characterization and quantification of different forms of pepsin. "
08/04/1989 - "This will facilitate the study of pepsin secretion, particularly in patients with peptic ulcer disease."
05/01/1987 - "However, studies in animal models of peptic ulcer indicate clearly that pepsin, in combination with acid, produces much more severe and more extensive mucosal damage than acid alone. "
04/01/1999 - "Recent studies of ulcer pathogenesis in the pig have shown that feed preparation or prolonged fasting can result in disruption of the normal stratification of gastric contents, thereby allowing high concentrations of HCl, pepsin and refluxed bile to mix in the proximal stomach. "
01/01/1988 - "The acid inhibitory action of drugs was not important in our study since the ulcer model employed consisted of perfusing the stomach continuously, at a high intraluminal pressure (120 mm H2O), with a simulated gastric juice (0.1 M HCl plus 600 mg pepsin/l). "
01/01/1963 - "Studies on pepsin secretion in healthy subjects and ulcer patients."
02/01/2016 - "In pylorus-ligated rats, the extract increased gastric content volume (p < 0.01), free acidity (p < 0.01), total acidity (p < 0.01), ulcer index (p < 0.01), and pepsin activity (p < 0.05). "
03/01/2015 - "The extract significantly (P< 0.05) decreased gastric acidity, gastric acid output, gastric pepsin secretion, ulcer index and gastric secretion volume relative to group B. "
|2.||Antigen-Antibody Complex (Immune Complex)
|3.||Proteins (Proteins, Gene)
|7.||Bile Acids and Salts (Bile Acids)
|2.||Proximal Gastric Vagotomy