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Pentolinium Tartrate (Pentolonium Tartrate)

A nicotinic antagonist that has been used as a ganglionic blocking agent in hypertension.
Also Known As:
Pentolonium Tartrate; Pentolinium; Tartrate, Pentolinium; Tartrate, Pentolonium; Pyrrolidinium, 1,1'-(1,5-pentanediyl)bis(1-methyl)-, salt with (R-(R*,R*))-2,3-dihydroxybutanedioic acid (1:2)
Networked: 125 relevant articles (8 outcomes, 4 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1. Busnardo, Cristiane: 6 articles (10/2013 - 01/2009)
2. Corrêa, Fernando Morgan Aguiar: 5 articles (10/2013 - 12/2005)
3. Corrêa, F M A: 5 articles (05/2007 - 05/2005)
4. Head, Geoffrey A: 4 articles (10/2013 - 04/2008)
5. Resstel, L B M: 4 articles (05/2007 - 05/2005)
6. Pelosi, Gislaine Garcia: 3 articles (11/2012 - 12/2005)
7. Tavares, Rodrigo Fiacadori: 3 articles (11/2012 - 02/2008)
8. Zicha, Josef: 3 articles (08/2011 - 03/2002)
9. Boomsma, Frans: 3 articles (04/2009 - 10/2002)
10. Osmond, Daniel H: 3 articles (04/2009 - 10/2002)

Related Diseases

1. Ganglion Cysts (Ganglion)
2. Tachycardia (Tachyarrhythmias)
05/01/1978 - "The decrease in arterial pressure 5 min after the administration of pentolinium was accompanied by tachycardia, but there was no significant change in cardiac index and the operative field was congested. "
07/01/1986 - "Inasmuch as pharmacological ganglion blockade with pentolinium eliminated increases in splanchnic nerve firing but reduced the attendant tachycardia by only 50%, residual tachycardia after ganglion blockade was considered partly due to persistent sympathetic cardioaccelerator tone. "
12/01/1995 - "Pretreatment with the ganglion blocker, pentolinium (10 mg/kg), had little effect on the blood pressure response, however it attenuated the tachycardia. "
01/01/2003 - "In addition, significant increases in heart rate were observed 5-15 min after ICV urotensin II. Pre-treatment with pentolinium (5 mg/kg, i.v.) significantly attenuated the increases in mean arterial pressure (20 +/- 3 versus 8 +/- 2 mmHg, P <0.01) and heart rate (78 +/- 18 versus 7 +/- 5 beats/min, P <0.05) induced by ICV urotensin II. On the other hand, i.v. injection of urotensin II (10 nmol) elicited a depressor response associated with tachycardia; mean arterial pressure 5 min after injection was significantly lower in the urotensin II-injected rats (89 +/- 5 mmHg) than in the control rats (102 +/- 2 mmHg, P <0.05), and the heart rate was significantly higher in the former (402 +/- 11 versus 360 +/- 9 beats/min, respectively, P <0.05). "
12/01/1976 - "The vasodilator, diazoxide, lowered blood pressure, widened pulse pressure and caused tachycardia in rats pre-treated with pentolinium. "
3. Hypertension (High Blood Pressure)
4. Bradycardia
5. Hypotension (Low Blood Pressure)

Related Drugs and Biologics

1. Propranolol (Inderal)
2. Atropine (Hyoscyamine)
3. Capsaicin (Zostrix)
4. Vasopressins (Vasopressin)
5. Ghrelin
6. Muscarinic Receptors (Muscarinic Acetylcholine Receptor)
7. Captopril (Capoten)
8. human NPPA protein (carperitide)
9. NG-Nitroarginine Methyl Ester (L-NAME)
10. Streptozocin (Streptozotocin)

Related Therapies and Procedures

1. Intravenous Injections
2. Vagotomy
3. Injections
4. Chemical Sympathectomy
5. Intravenous Infusions