Pentachlorophenol (Sodium Pentachlorophenate)

An insecticide and herbicide that has also been used as a wood preservative. Pentachlorphenol is a widespread environmental pollutant. Both chronic and acute pentachlorophenol poisoning are medical concerns. The range of its biological actions is still being actively explored, but it is clearly a potent enzyme inhibitor and has been used as such as an experimental tool.

Also Known As:

Sodium Pentachlorophenate; Pentachlorophenate, Sodium; Phenol, pentachloro-

Networked: 166 relevant articles (1 outcomes, 27 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        Chlorophenols: 95
        Pentachlorophenol: 166
        Hycolin: 1
        methylsulfonylpentachlorobenzene: 1
        2-bromo-3,4,5,6-tetrachlorophenol
        pentachlorophenol glucuronide
        pentachlorophenyl palmitate

Experts

1.	Huang, Fen: 5 articles (11/2021 - 01/2013)
2.	Lin, Po-Hsiung: 3 articles (02/2005 - 11/2002)
3.	Zhang, Chi: 2 articles (11/2021 - 01/2015)
4.	Zhong, Qi: 2 articles (11/2021 - 05/2017)
5.	Stuckey, David C: 2 articles (07/2019 - 04/2015)
6.	Sze, Chun Chau: 2 articles (07/2019 - 04/2015)
7.	Xiao, Yeyuan: 2 articles (07/2019 - 04/2015)
8.	Shan, Xiaomei: 2 articles (05/2017 - 01/2015)
9.	Liu, Zhengtao: 2 articles (01/2017 - 04/2010)
10.	Zhang, Qian: 2 articles (04/2015 - 01/2013)

Related Diseases

1.	Pheochromocytoma 03/01/1989 - "The incidences of pheochromocytomas in male mice were significantly greater than those in controls for both technical-grade pentachlorophenol (0/31; 10/45, 22&percnt;; 23/45, 51&percnt;) and EC-7 (1/34, 3&percnt;; 4/48, 8&percnt;; 21/48, 44&percnt;; 45/49, 92&percnt;). " 01/01/2003 - "A marked reduction in CGA expression occurred in pheochromocytomas induced by technical grade pentachlorophenol, compared to the other three chemicals and the spontaneously occurring tumors. "
2.	Hemangiosarcoma (Angiosarcoma) 03/01/1989 - "The incidences of hemangiosarcomas in the spleen and/or liver were significantly greater than those in controls for high dose female mice that received technical-grade pentachlorophenol (0/35; 3/50, 6&percnt;; 6/50, 12&percnt;) or EC-7 (0/35; 1/50, 2&percnt;; 3/50, 6&percnt;; 8/49, 16&percnt;). " 03/01/1989 - "There was clear evidence of carcinogenic activity for female B6C3F1 mice exposed to pentachlorophenol, EC-7, as shown by increased incidences of adrenal medullary and hepatocellular neoplasms and hemangiosarcomas. " 03/01/1989 - "There was some evidence of carcinogenic activity for female B6C3F1 mice exposed to technical-grade pentachlorophenol, as shown by increased incidences of hemangiosarcomas and hepatocellular neoplasms. " 03/01/2004 - "Two chemicals (pentachlorophenol and tetrafluoroethylene) increased the incidence of liver hemangiosarcoma in male and female mice, with no increase in Kupffer cell pigmentation. "
3.	Neoplasms (Cancer) 01/01/2013 - "Pervious studies suggested occupational workers exposure to pentachlorophenol (PCP) might contribute to increased risk of cancer. " 01/01/2013 - "Historical long-term exposure to pentachlorophenol causing risk of cancer--a community study." 08/01/2008 - "The pentachlorophenol studies presented considerable evidence pertaining to hematopoietic cancers, with strong associations seen in multiple studies, in different locations, and using different designs. " 03/01/2008 - "The epidemiological data based on the exposure of pentachlorophenol (PCP) and cancer incidence and mortality were analyzed to study the relationship between PCP exposure and cancer risk. " 04/01/2003 - "We conducted a study to evaluate whether the tumor-promoting activity of pentachlorophenol (PCP) is mainly from its major metabolite tetrachlorohydroquinone (TCHQ). "
4.	Carcinogenesis 04/01/1999 - "NTP Toxicology and Carcinogenesis Studies of Pentachlorophenol (CAS NO. 87-86-5) in F344/N Rats (Feed Studies)." 03/01/1999 - "Toxicology and carcinogenesis studies of pentachlorophenol in rats." 10/01/1991 - "Toxicology and carcinogenesis studies of two grades of pentachlorophenol in B6C3F1 mice." 03/01/1989 - "NTP Toxicology and Carcinogenesis Studies of Two Pentachlorophenol Technical-Grade Mixtures (CAS No. 87-86-5) in B6C3F1 Mice (Feed Studies)." 01/01/2014 - "To explore the role of oxidative stress in chemical carcinogenesis driven by non-genotoxic mechanisms, nrf2-deficient (nrf2(-/-)) and nrf2-wild-type (nrf2(+/+)) mice were exposed to pentachlorophenol (PCP) at concentrations of 600 or 1200 ppm for 60 weeks, or piperonyl butoxide (PBO) at concentrations of 3000 or 6000 ppm in the diet for 52 weeks, respectively. "
5.	Poisoning 01/01/1978 - "A pharmacokinetic study of pentachlorophenol poisoning and the effect of forced diuresis." 02/01/1954 - "[Experimental sodium pentachlorophenate poisoning in the guinea pig; therapeutic trials]." 05/01/2004 - "The method has been proven useful in the forensic cases involved in the poisoning of pentachlorophenol." 01/01/2003 - "Pentachlorophenol poisoning." 07/01/2001 - "Assessment of pentachlorophenol-exposed timber workers using a test-of-poisoning model."

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	Proteins (Proteins, Gene)
3.	RNA (Ribonucleic Acid)
4.	Hexachlorobenzene (HCB)
5.	Hexachlorocyclohexane (gamma-Hexachlorocyclohexane)
6.	DDT
7.	Chlorinated Hydrocarbons
8.	Heptachlor
9.	Chlordan (Chlordane)
10.	Benzo(a)pyrene

Related Therapies and Procedures

1.	Bioreactors (Bioreactor)
2.	Oral Administration
3.	Intraperitoneal Injections
4.	Electrodes (Electrode)