Penicillin G Procaine (Procaine, Benzylpenicillin)

Semisynthetic antibiotic prepared by combining penicillin G with PROCAINE.

Also Known As:

Procaine, Benzylpenicillin; Benzylpenicillin Procaine; Jenacillin; Procaine Penicillin; G Procaine, Penicillin; Penicillin, Procaine; Procaine, Penicillin G; 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-((phenylacetyl)amino)- (2S-(2alpha,5alpha,6beta))-, compd. with 2-(diethylamino)ethyl 4-aminobenzoate (1:1), monohydrate

Networked: 354 relevant articles (30 outcomes, 33 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Cousens, Simon: 4 articles (05/2015 - 09/2013)
2.	Adejuyigbe, Ebunoluwa A: 3 articles (01/2021 - 05/2015)
3.	Anyabolu, Chineme Henry: 3 articles (01/2021 - 05/2015)
4.	Ayede, Adejumoke Idowu: 3 articles (01/2021 - 05/2015)
5.	Esamai, Fabian: 3 articles (01/2021 - 05/2015)
6.	Falade, Adegoke Gbadegesin: 3 articles (01/2021 - 05/2015)
7.	Gisore, Peter: 3 articles (01/2021 - 05/2015)
8.	Gram, Lu: 3 articles (01/2021 - 05/2015)
9.	Tshefu, Antoinette: 3 articles (01/2021 - 05/2015)
10.	Wammanda, Robinson D: 3 articles (01/2021 - 05/2015)

Related Diseases

1.	Infections 01/15/1989 - "A 2.5-month-old calf, with Clostridium chauvoei infection of the right hip and stifle region, was treated successfully with procaine penicillin G. " 05/01/1989 - "After 30 days from the infection all animals were given procaine penicillin in daily doses of 75,000 mu/kg. The treatment was carried on for 20 days. " 08/01/1988 - "His condition responded briskly to treatment with procaine penicillin, and we conclude that the clinical features were attributable to infection with Treponema pallidum." 01/01/1985 - "Treatment with procaine penicillin, 300,000 U every 12 hr, was begun one to two days after infection. " 12/01/1979 - "Familiar antecedents, mechanism of infection, clinical symptoms and radiological findings are analized, emphasizing the importance of prophylaxis and early treatment with procaine penicillin in a dosage of 50,000 U./Kg. day for at least ten days."
2.	Gonorrhea 09/01/1987 - "The high endemicity of both types of resistance in some regions precludes the continued routine use of procaine penicillin (APPG) as treatment for gonorrhea. " 03/21/1980 - "The intramuscular (IM) injection of penicillin G procaine, 4.8 million units, with 1 g of probenicid given orally is the treatment of choice for anorectal gonorrhea. " 03/01/1972 - "Public Health Service-recommended dosages of aqueous procaine penicillin G in the treatment of uncomplicated gonorrhea in 353 men and 314 women. " 03/01/1971 - "Effect of double dose of aqueous procaine penicillin to treat gonorrhea in men." 05/01/1953 - "[Procaine penicillin in the treatment of gonorrhea in men]."
3.	Mastitis 02/01/2018 - "To investigate the comparative therapeutic efficacy of Phyllanthus emblica (Amla) fruit extract and procaine penicillin in the treatment of subclinical mastitis, a total of 30 subclinical mastitis positive buffaloes out of 194 lactating buffaloes were divided into 3 equal groups viz. " 02/01/2018 - "Comparative therapeutic efficacy of Phyllanthus emblica (Amla) fruit extract and procaine penicillin in the treatment of subclinical mastitis in dairy buffaloes." 02/16/2009 - "The objective of this field trial was to determine whether preventative treatment of heifers with a single parenteral treatment of 15 million iu micronised procaine penicillin within 12h after calving would reduce the incidence of clinical mastitis in early lactation as detected by farmers. " 02/16/2009 - "Preventative treatment of heifers immediately following calving with 15 million iu micronised procaine penicillin parenterally could be of benefit as part of a control programme aimed at reducing the incidence of clinical mastitis in heifers in their first lactation." 02/16/2009 - "Periparturient use of parenteral micronised procaine penicillin to reduce the risk of clinical mastitis in heifers after calving."
4.	Endocarditis 06/01/1983 - "Despite attempted prophylaxis with procaine penicillin G, endocarditis developed in 44 of 70 rabbits (63%) injected with the tolerant strains, contrasting with 2 of 22 (9%) for the non-tolerant strain (P=0.0001). " 02/01/1983 - "In rabbits with experimental endocarditis, treatment with procaine penicillin (250 mg/kg intramuscularly twice daily for 5 days) decreased the number of viable organisms in valvular vegetations from 8.82 log10 +/- 0.98 CFU/g in untreated controls to 5.31 +/- 1.19 for a highly tolerant strain, 4.22 +/- 1.05 for a less tolerant strain, and 1.79 +/- 1.72 for a nontolerant strain (P less than or equal to 0.01 for comparison between any of the four groups). " 02/01/1984 - "The contributions of granulocytes to the prevention and therapy of Streptococcus sanguis endocarditis with procaine benzylpenicillin (PBP) was investigated in rabbits. " 04/01/1987 - "In-vivo studies of aortic valve endocarditis in rabbits treated with procaine penicillin G (300 mg/kg/day) revealed strikingly different responses between infections due to one tolerant and one non-tolerant strain. " 09/01/1989 - "Daptomycin, however, was not as effective as a single daily dose of 600,000 U of procaine penicillin for endocarditis caused by the strain of S. "
5.	Syphilis 10/01/1985 - "The condylomata lata responded well to treatment of the syphilis with procaine penicillin G." 09/10/1999 - "Compared with short-acting procaine penicillin G, BPG has a longer half-life considered essential for effective syphilis treatment because it yields sustained spirochetecidal levels needed to treat the slowly reproducing agent of syphilis, Treponema pallidum. " 11/09/1980 - "[Neonatal syphilis and procaine penicillin]." 11/01/1963 - "[RESULTS OF PROCAINE PENICILLIN TREATMENT OF RECENT SYPHILIS]." 03/01/1955 - "[Treatment of syphilis with procaine penicillin preparations]."

Related Drugs and Biologics

1.	Penicillins (Penicillin)
2.	Probenecid (Benemid)
3.	Gentamicins (Gentamicin)
4.	Penicillin G (Benzylpenicillin)
5.	Ceftriaxone (Ceftriaxon)
6.	Penicillin G Benzathine (Benzathine Benzylpenicillin)
7.	Streptomycin (Streptomycin Sulfate)
8.	Doxycycline (Periostat)
9.	Trimethoprim (Proloprim)
10.	Anti-Bacterial Agents (Antibiotics)

Related Therapies and Procedures

1.	Therapeutics
2.	Injections
3.	Chemoprevention
4.	Oral Administration
5.	Intramuscular Injections