Penfluridol (Semap)

01/01/2014 - "In vivo penfluridol was particularly effective at inhibiting LL/2 lung tumor growth, and obviously prolonged the survival time of mice bearing LL/2 lung tumors implanted subcutaneously. "
02/15/2016 - "We further evaluated the efficacy of penfluridol in three different in vivo tumor models. "
06/01/2017 - "Altogether, our study establishes that penfluridol-induced endoplasmic reticulum stress leads to autophagy resulting in reduced pancreatic tumor growth. "
01/01/2016 - "These studies established that penfluridol inhibits pancreatic tumor growth by autophagy-mediated apoptosis. "
01/01/2014 - "To test this, we conducted a study to determine whether penfluridol exerts cytotoxic effects on tumor cells and, if so, to explore its anti-tumor mechanisms. "

12/01/2020 - "In conclusion, penfluridol represents a promising treatment option for bladder cancer patients and warrants further clinical evaluation."

01/01/2019 - "Penfluridol is clinically used for schizophrenia, and our study results strongly support penfluridol as a repurposed drug for treating NSCLC."
08/01/1978 - "A controlled study of penfluridol in the treatment of chronic schizophrenia."
01/26/1977 - "Penfluridol: a double blind trial in chronic schizophrenia."
05/01/1976 - "A long-term study of penfluridol in chronic schizophrenia."
03/01/2019 - "Penfluridol, a Unique Psychiatric Medicine for the Treatment of Chronic Schizophrenia."

05/16/2017 - "Penfluridol treatment suppressed the phosphorylation of Akt at Ser473 and reduced the expression of GLI1, OCT4, Nanog and Sox2 in several glioblastoma cell lines in a concentration-dependent manner. "
07/18/2017 - "The present study evaluates the immune response of penfluridol in glioblastoma tumors. "
07/18/2017 - "This is the first report demonstrating immune modulations by penfluridol treatment associated with glioblastoma tumor growth suppression prompting further investigation to establish penfluridol as a treatment option for glioblastoma patients."
07/18/2017 - "Our current results demonstrated about 72% suppression of myeloid derived suppressor cells (MDSCs) with penfluridol treatment in mouse bearing U87MG glioblastoma tumors. "
07/18/2017 - "Our results demonstrated that penfluridol treatment significantly suppressed glioblastoma tumor growth. "

06/01/2022 - "Our study results strongly support that a combination of repurposing penfluridol and a glycolysis inhibitor would be a good strategy for enhancing the anticancer activities of penfluridol in lung cancer."
01/01/2020 - "In this present study, we investigated the anticancer potential of penfluridol (PF), an anti-schizophrenic drug, in lung cancer and its underlying mechanism in vitro and in vivo. "
06/01/2022 - "In an orthotopic lung cancer mouse model, the anticancer activities of penfluridol, including growth and metastasis inhibition, were also enhanced by combined treatment with 2DG. "
06/01/2022 - "Herein, we discovered that treatment of A549 and HCC827 lung cancer cells with penfluridol caused a decrease in the total amount of ATP, especially in A549 cells. "
01/01/2019 - "Penfluridol, an antipsychotic drug, has been reported to exert oncostatic effects, but the effect of penfluridol on lung cancer remains unknown. "