|1.||Kikuchi, Hideaki: 2 articles (01/2014 - 08/2011)|
|2.||Maresca, Marc: 2 articles (04/2008 - 06/2002)|
|3.||Fantini, Jacques: 2 articles (04/2008 - 06/2002)|
|4.||Kim, Ha-Jung: 1 article (12/2015)|
|5.||Lee, Seung-Hwa: 1 article (12/2015)|
|6.||Lee, Eun: 1 article (12/2015)|
|7.||Hong, Soo-Jong: 1 article (12/2015)|
|8.||Kang, Mi-Jin: 1 article (12/2015)|
|9.||Lteif, Roger: 1 article (09/2015)|
|10.||Tannous, Joanna: 1 article (09/2015)|
|1.||Body Weight (Weight, Body)
11/01/1978 - "Resorption of all implanted embryos occurred at 2.0 mg/kg/day of patulin, while a significant reduction in the average body weight of 19-day-old fetuses from patulin-treated mothers, compared to control fetuses, was noticed at 1.5 mg/kg/day without any lethal effects on the implanted embryos. "
01/01/2015 - "Animals from the experimental groups (group E♂, n = 3; group E♀, n = 4) were injected intramuscularly with patulin at dose 10 μg/kg body weight two times a week for 28 days. "
01/01/2008 - "The estimated intake of patulin ranged from 0.1 to 1.5 ng kg(-1) body weight for the whole population and from 0.3 to 5.1 ng kg(-1) body weight for the consumers only. "
11/01/2007 - "Based on these results and juice consumption by the Spanish adult population, patulin estimated intake was 0.42 ng kg(-1) body weight per day."
01/15/2007 - "Human exposure to patulin can lead to serious health problems, and according to a long-term investigation in rats, the World Health Organization has set a tolerable weekly intake of 7 ppb body weight. "
09/01/2015 - "Apples are suitable substrates for fungal colonization mostly caused by Penicillium expansum, which produces the mycotoxin patulin during fruit infection. "
11/09/2011 - "The infection of stored apples by the fungus Penicillium expansum causes the contamination of fruits and fruit-derived products with the mycotoxin patulin, which is a major issue in food safety. "
07/01/2011 - "[Research on patulin biosynthesis and infection of Chinese medicinal materials by its producing strains]."
09/01/1988 - "Enhancing resistance and modulation of humoral immune response to experimental Candida albicans infection by patulin."
01/01/1979 - "As to products with subsequent mould infection, patulin values up to 50 mg/l were found in apple juices, and up to 0.4 mg/kg in peach preserves. "
01/01/2010 - "The UK Medical Research Council's (MRC) trial of patulin for common cold in 1943 was the first double blind controlled trial. "
04/01/2004 - "Four years earlier, however, a methodologically sophisticated multicentre trial conducted under the aegis of the Medical Research Council was reported, which assessed the effects of the antibiotic patulin on the course of common colds. "
04/01/2004 - "Clinical trial of patulin in the common cold. "
|4.||Colonic Neoplasms (Colon Cancer)
01/01/2014 - "Treatment of Caco-2 human colon cancer cells, used as a colon epithelial model, with 50 µM patulin decreased the level of density-enhanced phosphatase-1 (DEP-1) protein to 30% of the control level after 6 h. "
01/01/2014 - "The mycotoxin patulin decreases expression of density-enhanced phosphatase-1 by down-regulating PPARγ in human colon cancer cells."
08/28/2011 - "The transepithelial electrical resistance (TER) of Caco-2 human colon cancer cells decreased gradually during the first 24h of treatment with 50μM patulin. "
08/28/2011 - "Correlation between the destruction of tight junction by patulin treatment and increase of phosphorylation of ZO-1 in Caco-2 human colon cancer cells."
04/01/2012 - "In this study, patulin was found to induce G1/S accumulation and cell growth arrest accompanied by caspase-3 activation, PARP cleavage and ATF3 expression in human colon cancer cell line HCT116. "
|5.||Wounds and Injuries (Trauma)
11/29/1974 - "[Histopothological studies of injuries induced in mice with intraperitoneal and intracerebral injections of patulin]."
06/15/2002 - "In addition to being toxic for animals, mutagenic, carcinogenic and teratogenic, patulin induces intestinal injuries, including epithelial cell degeneration, inflammation, ulceration, and hemorrhages. "
|2.||Caspase 3 (Caspase-3)
|3.||Citric Acid (Citrate)
|4.||Glutathione (Reduced Glutathione)
|6.||Reactive Oxygen Species (Oxygen Radicals)
|9.||Prostaglandins F (PGF)
|10.||Prostaglandins E (PGE)