Parathyroid Hormone (Parathormone)

A polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of CALCIUM from BONE, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates.

Also Known As:

Networked: 11951 relevant articles (258 outcomes, 1059 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Fukagawa, Masafumi: 71 articles (06/2022 - 03/2002)
2.	Bilezikian, John P: 66 articles (09/2021 - 05/2002)
3.	Jüppner, Harald: 38 articles (06/2022 - 11/2002)
4.	Cozzolino, Mario: 34 articles (01/2021 - 10/2002)
5.	Chen, Herbert: 33 articles (01/2021 - 08/2002)
6.	Moe, Sharon M: 29 articles (03/2022 - 01/2003)
7.	Akizawa, Tadao: 27 articles (06/2022 - 01/2002)
8.	Rejnmark, Lars: 26 articles (01/2022 - 12/2008)
9.	Komaba, Hirotaka: 26 articles (01/2021 - 08/2008)
10.	Brandi, Maria Luisa: 24 articles (01/2022 - 05/2009)

Related Diseases

1.	Osteoporosis 01/01/2012 - "Intermittent administration of parathyroid hormone (PTH) dramatically increases bone mass and currently is one of the most effective treatments for osteoporosis. " 05/01/2006 - "Clinical data suggested that parathyroid hormone (PTH) might be effective in improving bone mass in patients with osteoporosis, providing its resorptive effects, which are particularly marked at cortical sites, were kept under control. " 07/01/2010 - "Parathyroid hormone (PTH) is the first bone anabolic drug approved for the treatment of osteoporosis, and intriguingly a number of animal studies suggest that PTH could be beneficial in the treatment of fractures and could thus be a potentially new treatment option for induction of fracture healing in humans. " 04/01/2016 - "Parathyroid hormone (PTH) (1-34) has already been shown to be beneficial in osteoporosis, lumbar fusion and matrix homeostasis of intervertebral discs. " 08/31/2006 - "Parathyroid hormone in the recommended dose of 20 g daily has proved to be a safe and effective drug, stimulating the reconstruction of structurally damaged bone and significantly decreasing fracture risk in patients with severe osteoporosis."
2.	Secondary Hyperparathyroidism 03/01/2008 - "Calcimimetics are effective in reducing parathyroid hormone (PTH) levels in patients with secondary hyperparathyroidism, but variability in dose response has been noted. " 06/01/2003 - "Data on potential benefits, including improved histologic abnormalities of bone from secondary hyperparathyroidism, increased bone mineral density, and a reduction of elevated parathyroid hormone levels, are documented. " 02/01/2016 - "Impaired renal clearance of parathyroid hormone may contribute to secondary hyperparathyroidism in CKD. " 03/01/2002 - "Secondary hyperparathyroidism decreases renal clearance of parathyroid hormone (PTH). " 10/01/2019 - "We suggest that new studies analyzing the effectiveness of therapeutic approaches to the management of secondary hyperparathyroidism should be directed not only to controlling parathyroid hormone levels but also to the evaluation of long-term outcomes, based on modification of morbidity, mortality, and end organ impact, while reducing side effects and controlling costs, among others."
3.	Primary Hyperparathyroidism 01/01/2022 - "Over the next century, progress in the evaluation of primary hyperparathyroidism, the identification of parathyroid hormone (PTH) and its application for use in the field of parathyroid surgery have led to a significant improvement in surgical cure rates, accompanied by a shift toward minimally invasive surgical options. " 02/25/1995 - "To evaluate the efficacy of rapid peroperative assay of parathormone in patients with primary hyperparathyroidism compared with the longer standard assay. " 12/01/2007 - "Measurement of qPTH (based solely on the criterion of greater than 50% decline of parathyroid hormone) in 72 patients with primary hyperparathyroidism (77 procedures) showed true-positive results in 69, false-positive results in 4, and true-negative results in 4 procedures. " 02/01/2009 - "The aim of our study was to evaluate the efficacy of Tc(99m) sestamibi preoperative imaging, intraoperative Tc(99m) sestamibi with gamma probe, and intraoperative parathyroid hormone (IOPTH) assessment in a large cohort of patients with primary hyperparathyroidism. " 01/01/2023 - "However, intraoperative parathyroid hormone decline in cured patients was lower in those with normohormonal primary hyperparathyroidism (66.4% vs 84.5%, P < .0001). "
4.	Hypercalcemia (Milk Alkali Syndrome) 07/01/2004 - "Is there enough evidence that evening dosing is more beneficial with respect to suppression of parathyroid hormone and reduction of side effects such as hypercalcemia?" 08/01/1988 - "Improved differential diagnosis of hypercalcemia by hypocalcemic stimulation of parathyroid hormone secretion." 10/01/2023 - "In present study we evaluated a 39-year-old man with hypercalcemia and parathyroid hormone. " 08/01/2023 - "Initial laboratory studies revealed hypercalcemia and elevated parathyroid hormone levels. " 08/01/2016 - "Kidney allograft recipients with hypercalcemia and elevated intact parathyroid hormone (iPTH) concentration were eligible if they had received a transplant ≥6 months before the study and had an eGFR>30 ml/min per 1.73 m(2) The primary end point was the proportion of patients with normocalcemia at 12 months. "
5.	Hyperparathyroidism 01/01/2002 - "During the last five years, minimally invasive procedures have been adopted for the surgical treatment of hyperparathyroidism, because preoperative localization studies such as high-resolution ultrasonography and sestamibi scintigraphy, guidance by intraoperative scans, and the use of quick, intraoperative parathyroid hormone assay have improved. " 11/01/2020 - "These studies suggest that parathyroid surgery appears to be effective in normalizing elevated serum parathyroid hormone concentrations and decreasing adverse renal and skeletal outcomes in patients with normocalcaemic hyperparathyroidism. " 06/01/2010 - "Calcimimetics are effective in lowering serum parathyroid hormone (PTH) levels in hyperparathyroidism (HPT). " 09/01/2011 - "Intraoperative parathyroid hormone (IoPTH) testing is useful in the management of hyperparathyroidism. " 08/01/1995 - "Comparing the drop in intact parathormone levels between cured patients and those with persistent hyperparathyroidism after surgery showed statistically significant differences. "

Related Drugs and Biologics

1.	Calcium
2.	Phosphorus (Red Phosphorus)
3.	Vitamin D
4.	Cinacalcet (Sensipar)
5.	Alkaline Phosphatase
6.	Calcitriol (Calcijex)
7.	Teriparatide (Parathar)
8.	Diphosphonates (Bisphosphonates)
9.	Minerals
10.	Cholecalciferol (Vitamin D3)

Related Therapies and Procedures

1.	Therapeutics
2.	Parathyroidectomy
3.	Renal Dialysis (Hemodialysis)
4.	Thyroidectomy
5.	Aftercare (After-Treatment)