Parasitic Diseases (Parasitic Disease)

Infections or infestations with PARASITES. They are often contracted through contact with an intermediate vector, but may occur as the result of direct exposure.

Also Known As:

Parasitic Disease; Diseases, Parasitic; Parasite Infections; Parasitic Infections; Disease, Parasitic; Infection, Parasite; Infection, Parasitic; Infections, Parasite; Infections, Parasitic; Parasite Infection; Parasitic Infection

Networked: 4870 relevant articles (222 outcomes, 426 trials/studies)

Relationship Network

Disease Context: Research Results

Infections: 526564
- Parasitic Diseases: 4870

Related Diseases

1.	Infections
2.	Malaria
3.	Neoplasms (Cancer)
4.	Leishmaniasis
5.	Schistosomiasis (Bilharziasis)

Experts

1.	Luckhart, Shirley: 21 articles (11/2021 - 05/2005)
2.	Utzinger, Jürg: 17 articles (01/2022 - 08/2004)
3.	McKerrow, James H: 17 articles (12/2017 - 01/2005)
4.	Keiser, Jennifer: 12 articles (07/2022 - 08/2009)
5.	Ndao, Momar: 10 articles (06/2022 - 04/2004)
6.	Soboslay, Peter T: 9 articles (01/2022 - 06/2003)
7.	Yazdanbakhsh, Maria: 9 articles (01/2022 - 01/2003)
8.	Morales-Montor, Jorge: 9 articles (11/2021 - 01/2009)
9.	McManus, Donald P: 9 articles (06/2017 - 10/2002)
10.	Maya, Juan Diego: 8 articles (03/2022 - 06/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Parasitic Diseases:

1.	VaccinesIBA 02/01/2013 - "Different models have been extensively used to investigate putative immunological correlates of protection against parasitic diseases that are important to reach a successful vaccine. " 11/27/1981 - "Characterization of the S-phase cell surface components responsible for this phenomenon could be beneficial in the development of vaccines against these parasitic diseases." 01/01/2020 - "For a long time, vaccines have been the main mode of defense and protection against several bacterial, viral, and parasitic diseases. " 01/01/2012 - "There is no licensed vaccine available for any human parasitic disease and drug resistance is compromising the efficacy of many available anti-parasitic drugs. " 03/26/2009 - "A vaccine that elicits both cell-mediated and humoral immune responses might be needed for protection against this multistage parasitic infection. "
2.	Antiparasitic Agents (Antiparasitics)IBA 04/01/2007 - "Antiparasitic drugs have been used successfully to control parasitic diseases in animals for many years, as they are safe, cheap and effective against a broad spectrum of parasites. " 01/01/2021 - "Consequently, this study emphasizes that diagnosis of parasitic infections and the routine use of antiparasitic medications should be encouraged by veterinarians and to owners in order to reduce the reservoir of potentially zoonotic parasites." 03/27/2019 - "Therefore, this systematic review describes several studies performed with nanoemulsions as carriers of EOs that have larvicidal, insecticidal, repellent, acaricidal and antiparasitic activities, and thus can be considered as alternatives in the vector control of infectious and parasitic diseases, as well as in the combat against etiological agents of parasitic origin." 01/01/1991 - "The emergence of new parasitic diseases has encouraged studies on the elucidation of the mode of action of new and old antiparasitic drugs, and has led to the development of new chemical series. " 11/30/2023 - "Parasitic infections challenge vertebrate health worldwide, and off-target effects of antiparasitic treatments may be an additional obstacle to recovery. "
3.	Ivermectin (Mectizan)FDA Link 08/01/2004 - "Mass treatment with ivermectin was an effective and safe means of reducing the prevalence of most of the parasitic diseases prevalent in a poor community in north-east Brazil. " 01/01/2021 - "Campbell won the 2015 Nobel Prize in Physiology or Medicine for the discovery of the excellent efficacy of ivermectin against parasitic diseases. " 08/01/2019 - "The current research trend is focused toward the need for developing ivermectin formulations that are stable, effective, and safe and that reduce the number of doses required for complete clinical cure in different parasitic diseases. " 08/17/1985 - "Ivermectin at 50 micrograms/kg or higher was 99 per cent or more effective against all induced parasite infections with the exception of ivermectin at 50 micrograms/kg against S papillosus (97 per cent). " 01/01/2022 - "Ivermectin is a safe and effective drug in humans and has been approved for use in numerous parasitic infections for over 50 years. "
4.	AntigensIBA 11/01/2014 - "Immunoassays for parasitic antigens are not available for most parasitic infections and have not significantly improved the sensitivity of laboratory detection. " 05/01/2010 - "immunization with rPM/CT failed to provide protection against parasite infection, albeit the antigen was a very potent mucosal immunogen. " 12/01/2020 - "Western blot (WB) technique showed promising results for antigen recognition patterns in several parasitic infections. " 01/01/2013 - "They allow for a population of antigen specific T cells to be monitored during developing responses to immunization or parasite infection; this makes them particularly useful to study fundamental aspects of T cell activation, differentiation, and migration in different tissue compartments. " 01/01/1995 - "A workshop for collaborative study on circulating Schistosoma japonicum antigen detection was held at the Hunan Institute of Parasitic Diseases, Yueyang, Hunan Province in May, 1993. "
5.	AntibodiesIBA 01/01/2021 - "This study aims to obtain information on Toxoplasma specific antibodies and to measure the risk factor associate with parasite infection. " 07/01/2020 - "The present study aimed to determine the prevalence of antibodies against T. equi in equids in the western region of the State of Pará, Brazil, and to identify potential risk factors associated with parasite infection. " 01/01/2019 - "The present study aimed to determine the prevalence of antibodies against Toxoplasma gondii and Neospora spp. in equids raised for distinct purposes in the western state of Pará, Brazil, and to identify potential risk factors associated with parasite infection. " 01/01/2018 - "Taking advantage of newly developed tools, such as basophil-depleting antibodies and engineered mice deficient for only basophils, recent studies have identified previously unappreciated roles for basophils, distinct from those played by mast cells, in allergic responses, protective immunity against parasitic infections and regulation of other immune cells. " 03/01/2022 - "As a result, new knowledge has been published including empirically based treatment protocols, confirmatory techniques to detect the presence of the parasite infection and seasonal variation in the antibodies against Leishmania in apparently healthy domestic ferrets. "
6.	Proteins (Proteins, Gene)FDA Link 04/01/2012 - "Notably, treating animals with GITR-Fc fusion protein ameliorates autoimmune/inflammatory diseases while GITR triggering, by treatment with anti-GITR mAb, is effective in treating viral, bacterial and parasitic infections, as well in boosting immune response against tumours. " 10/01/2008 - "Schistosoma mansoni tegument protein Sm29 is able to induce a Th1-type of immune response and protection against parasite infection." 06/06/2007 - "Immunization with Leishmania infantum released proteins confers partial protection against parasite infection with a predominant Th1 specific immune response." 06/01/2023 - "A morphophysiological study of tubular reabsorption and mechanisms of protein endocytosis in the kidney of frogs (Rana temporaria L.) during parasitic infection was carried out. " 10/01/2021 - "Previous studies that have reported the presence of these proteins in worms, ectoparasites, and protozoa that cause parasitic infections have also been reviewed."
7.	EnzymesIBA 10/31/2023 - "Considering that previous studies indicated the pathological role of 3'-NT-/NU in parasite infection, we suggest that this enzyme may act as the mechanism of escape of A. " 01/01/2023 - "This study which involved targeting enzymes in biosynthetic pathways of the parasitic worms' endosymbiont (Wolbachia), has proven to be an alternative therapeutic option leading to the discovery of new drugs, which will help facilitate the elimination of parasitic infections." 01/15/1998 - "Studies on the function and structure of this enzyme may be important for therapeutic research in several parasitic diseases, since it has no counterpart in humans." 01/01/1977 - "ELIEDA (enzyme-linked-immuno-electro-diffusion-assay): application of a combined immunoelectrodiffusion and immunoenzyme method to the study of immune response in parasitic infections." 10/01/2023 - "Also, changes in chromatin remodeling enzymes suggest that parasite infection may shape the epigenome of the host cells. "
8.	Immunoglobulin E (IgE)IBA 08/08/2022 - "Mast cells (MCs) play key roles in IgE-mediated immunoresponses, including in the protection against parasitic infections and the onset and/or symptoms of allergic diseases. " 01/01/1985 - "Variations in the upper limit of normal total serum IgE have been reported: they can range from 150 to 1,000 UI/ml; but the usually accepted upper limit is between 150 and 300 UI/ml. In this study we measured the total serum IgE levels (RIST-Pharmacia) in 69 randomly selected control subjects; 38 had no previous history of atopic or parasitic disease. " 01/01/1981 - "The elevation of serum IgE in many parasitic diseases led us to study CSF and serum IgE in patients with CC diagnosed by pathologic, radiologic or clinical criteria. " 01/01/2023 - "As the α-subunit of the high-affinity receptor for the Fc portion of immunoglobulin E (FcεRIα), FcεRIα plays a central role in IgE-mediated allergic disorders and in the immunity and immunopathology of some parasitic infections. " 04/01/2022 - "Are humanized IgE reporter systems potential game changers in serological diagnosis of human parasitic infection?"
9.	DNA (Deoxyribonucleic Acid)IBA 01/01/2020 - "In this respect, the increased availability of specific DNA-detection procedures has improved the diagnosis of many imported parasitic infections. " 12/01/2009 - "In recent studies, heterologous prime-boost approaches, employing plasmid DNA and viral vector pathogen-delivering sequences, have been considered an effective protection strategy for intracellular parasite infections. " 10/25/2023 - "The amounts of parasite DNA in soil samples from different playgrounds and other public areas can help identify areas of possible microbe transmission as well as giving indications of possible occurrence of parasite infection in nearby communities. " 10/01/2023 - "Parasitic diseases are considered to be a cause of oxidative stress which leads to oxidative damage of various molecules including DNA. " 05/19/2023 - "Knowledge is only beginning to emerge about the participation of DNA webs in the host's battle against parasitic infections. "
10.	AnthelminticsIBA 10/01/2007 - "The positive outcomes of infrastructure building is realised in greater capacities for anthelmintic screening at institutions in the countries where the parasitic diseases are endemic and allows for optimum use of specialised resources for public health priority diseases that may be different from those in Western countries. " 12/01/2020 - "Innovative anthelmintic based on mechanochemical technology and their efficacy against parasitic infection of sheeps." 10/18/2021 - "The aim of this study was to describe the dynamics of parasite infections in captive Cuvier's gazelles (Gazella cuvieri) not treated with anthelmintics for two years and to evaluate the factors related to their fecal egg shedding. " 10/01/2017 - "The results of this study provide evidence that the common commercially available anthelmintic are not assuring effective chemical control of gastrointestinal parasitic infections in ovine flocks in the southern region of Rio Grande do Sul. " 10/01/2009 - "This paper summarizes the progress in the study on anthelmintics, including nematocide, trematocide and cestocide since the founding of the People's Republic of China and the roles that these agents played in the control of parasitic diseases. "

Therapies and Procedures

1.	Therapeutics 01/01/2021 - "The remarkable efficacy demonstrated by the MVEO/2017/nanoemulsion (EC50 = 0.10 mg/mL), supports its potential to be a candidate to the next-generation therapy to alleviate clinical parasite infections and combat GIN resistant populations." 12/01/2022 - "Efficacy of Mesenchymal Stem Cells Therapy in Parasitic Infections: Are Anti-parasitic Drugs Combined with MSCs More Effective?" 03/01/1992 - "In recent years, introduction of new and more effective agents has improved the overall therapy for parasitic infections. " 12/01/2022 - "In this study, the last pre-clinical advances in the efficacy of MSCs' therapy against parasitic diseases were reviewed. " 01/01/2011 - "Additionally, the antiretroviral therapy could exert a certain degree of protection against parasitic diseases. "
2.	Drug Therapy (Chemotherapy) 09/01/1990 - "The above mentioned biological approaches should increase the efficacy of chemotherapy in parasitic diseases with smaller amounts of specific drugs and less courses of treatment." 08/01/2013 - "Despite the progress that has been made in the study of its biochemistry and physiology, more efficient chemotherapies to control this parasitic infection are still lacking. " 01/01/1997 - "Oncologic patients receiving chemotherapy should have a coproparasitoscopic study to avoid disseminated parasitic infections. " 09/01/1995 - "There are three areas in which Australian scientists have made outstanding contributions to the study of the chemotherapy of human parasitic infections. " 02/01/1995 - "The results of this field study prove chemotherapy to be an important tool in the control of intestinal parasite infections."
3.	Bathroom Equipment 05/01/2023 - "To understand how the antihelminthic campaign since the 1960s helped reduce parasite infection rates in Korea, more research should focus on early-20th-century toilet ruins." 01/01/2000 - "These achievements were not due to an improvement of the availability of toilets or personal hygiene alone but more to the villagers' improved understanding of the route of the parasitic infections. " 01/01/2014 - "This study showed that good household and environmental hygiene, good toilet construction and usage, and proper utilization of ITN in Awramba cooperative community have significantly contributed to the reduction of the burden of parasitic infections. " 07/01/2009 - "Lack of education of mothers and children, improper toilets and failure to practice proper hand washing were perceived from this study as contributors to the acquisition of intestinal parasitic infections." 01/01/2022 - "Children's mother/guardian washed their hands sometimes after the toilet (AOR = 2.98, 95% CI: 1.09-8.18), children who always eat unwashed fruits and vegetables (AOR = 4.63, 95% CI: 1.09-19.75), and children's mother/guardian who had no knowledge about the mode of transmission (AOR = 4.03, 95% CI: 1.04-15.64) were risk factors significantly associated with increased intestinal parasitic infections. "
4.	Highly Active Antiretroviral Therapy (HAART) 01/01/2011 - "A number of studies have been evidenced a decrease in the incidence of opportunistic parasitic infections in the era of HAART. " 01/01/2021 - "Prevalence of Intestinal Parasitic Infection and Associated Factors Among HAART Initiated Children Attending at University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia." 05/20/2018 - "This parasitic disease has a high mortality rate, so it is mandatory to think about it in all the patients having a low CD4+ T-cell count and an inverted CD4/CD8 ratio under HAART." 09/01/2012 - "Prevalence of opportunistic intestinal parasitic infections among HIV-infected patients with low CD4 cells counts in France in the combination antiretroviral therapy era." 11/01/2001 - "Opportunistic parasitic infections of the intestinal tract in the era of highly active antiretroviral therapy: is the CD4(+) count so important?"
5.	Immunotherapy 12/01/2023 - "Understanding the immune system and lesion size of CL can help develop immunotherapies and comprehend the evolution of this parasitic disease." 05/01/2015 - "Prospectively, targeting FGL2 could be an option to develop an immunotherapy against AE and other chronic parasitic diseases." 08/01/2013 - "Better understanding of the complex interplay between parasites, host adaptive immunity, and relevant negative regulatory circuits will inform efforts to enhance resistance to chronic parasitic infections through vaccination or immunotherapy." 01/01/2003 - "Parallels between parasite infections and specific immunotherapy." 12/01/1995 - "The potential for design of prevention and/or intervention approaches against parasitic infection (e.g., vaccination or combination chemo- and immunotherapy strategies) on the basis of induction of cell-mediated immunity and NO production appears to be great, but the possible pathogenic consequences of overproduction of NO must be taken into account. "