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Progressive Bulbar Palsy (Fazio Londe Syndrome)

A motor neuron disease marked by progressive weakness of the muscles innervated by cranial nerves of the lower brain stem. Clinical manifestations include dysarthria, dysphagia, facial weakness, tongue weakness, and fasciculations of the tongue and facial muscles. The adult form of the disease is marked initially by bulbar weakness which progresses to involve motor neurons throughout the neuroaxis. Eventually this condition may become indistinguishable from AMYOTROPHIC LATERAL SCLEROSIS. Fazio-Londe syndrome is an inherited form of this illness which occurs in children and young adults. (Adams et al., Principles of Neurology, 6th ed, p1091; Brain 1992 Dec;115(Pt 6):1889-1900)
Also Known As:
Fazio Londe Syndrome; Bulbar Palsy; Progressive Bulbar Palsy of Childhood; Syndrome, Fazio-Londe; Bulbar Palsy, Progressive; Childhood Progressive Bulbar Palsy; Bulbar Palsies; Bulbar Palsies, Progressive; Bulbar Paralyses; Bulbar Paralysis; Palsies, Bulbar; Palsies, Progressive Bulbar; Palsy, Bulbar; Palsy, Progressive Bulbar; Progressive Bulbar Palsies; Fazio-Londe Syndrome; Paralysis, Bulbar
Networked: 84 relevant articles (4 outcomes, 3 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Ophthalmoplegia (External Ophthalmoplegia)
2. Deafness (Deaf Mutism)
3. Respiratory Insufficiency (Respiratory Failure)
4. Heart Arrest (Cardiac Arrest)
5. Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)

Experts

1. Aiba, Ikuko: 2 articles (07/2015 - 12/2013)
2. Nakagawa, Masanori: 2 articles (07/2015 - 12/2013)
3. Houlden, Henry: 2 articles (11/2013 - 03/2010)
4. Ijlst, Lodewijk: 2 articles (01/2012 - 02/2011)
5. Waterham, Hans R: 2 articles (01/2012 - 02/2011)
6. Bosch, Annet M: 2 articles (01/2012 - 02/2011)
7. Arnon, Stephen S: 2 articles (07/2008 - 04/2007)
8. Koga, M: 2 articles (06/2002 - 05/2001)
9. Yuki, N: 2 articles (06/2002 - 05/2001)
10. Yoshino, H: 2 articles (06/2002 - 06/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Progressive Bulbar Palsy:
1. Brown-Vialetto-Van Laere syndromeIBA
2. Intravenous Immunoglobulins (IVIG)FDA Link
3. Riboflavin (Vitamin B2)FDA LinkGeneric
4. Immunoglobulin G (IgG)IBA
5. AntibodiesIBA
6. Insulin-Like Growth Factor I (IGF-1)IBA
7. Insulin (Novolin)FDA Link
8. Immunoglobulin M (IgM)IBA
9. Botulinum Toxins (Botulinum Toxin)IBA
10. alpha-Fetoproteins (AFP)IBA

Therapies and Procedures

1. Plasmapheresis
2. Enteral Nutrition (Feeding, Tube)
3. Resuscitation
4. Artificial Respiration (Mechanical Ventilation)
5. Tracheostomy