Paraldehyde
A hypnotic and sedative with anticonvulsant effects. However, because of the hazards associated with its administration, its tendency to react with plastic, and the risks associated with its deterioration, it has largely been superseded by other agents. It is still occasionally used to control status epilepticus resistant to conventional treatment. (From Martindale, The Extra Pharmacopoeia, 30th ed, p608-9)
Also Known As:
1,3,5-Trioxane, 2,4,6-trimethyl-
Networked: 99
relevant articles (4 outcomes,
6 trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Experts
1. | Appleton, Richard:
2 articles
(10/2018 - 07/2008)
|
2. | Martland, Timothy:
2 articles
(10/2018 - 07/2008)
|
3. | Kubová, Hana:
2 articles
(01/2017 - 01/2005)
|
4. | Mares, P:
2 articles
(01/2007 - 01/2000)
|
5. | Hall, Elizabeth A:
1 article
(01/2020)
|
6. | Phelps, Stephanie J:
1 article
(01/2020)
|
7. | Wheless, James W:
1 article
(01/2020)
|
8. | Jannetto, Paul J:
1 article
(03/2019)
|
9. | Langman, Loralie J:
1 article
(03/2019)
|
10. | Sztajnkrycer, Matthew D:
1 article
(03/2019)
|
Related Diseases
1. | Tonic-Clonic Epilepsy (Epilepsy, Tonic Clonic)
|
2. | Seizures (Absence Seizure)
|
3. | Febrile Seizures (Febrile Seizure)
06/01/1993
- " Treatment of febrile convulsions depends upon a ready supply of quinine, chloramphenicol, and paraldehyde, a clean, well-lit treatment area for performing a lumbar puncture, and a standard treatment manual for gauging proper drug dosage. " 07/16/2008
- " Four trials involving 383 participants were included.(1) Intravenous lorazepam is as effective as intravenous diazepam in the treatment of acute tonic clonic convulsions, 19/27 (70%) versus 22/34 (65%), RR 1.09 (95% CI 0.77 to 1.54), has fewer adverse events and rectal lorazepam may be more effective than rectal diazepam, 6/6 versus 6/19 (31%), RR 3.17 (95% CI 1.63 to 6.14)(2) Buccal midazolam controlled seizures in 61/109 (56%) compared with 30/110 (27%) of rectal diazepam treated episodes with acute tonic-clonic convulsions, RR 2.05 ( 95% CI 1.45 to 2.91)(3) Intranasal midazolam is as effective as intravenous diazepam in the treatment of prolonged febrile convulsions, 23/26 (88%) versus 24/26 (92%), RR 0.96 (95% CI 0.8 to 1.14)(4) There is moderate evidence that intranasal lorazepam is more effective than intramuscular paraldehyde for acute tonic-clonic convulsions and patients treated with intranasal lorazepam are significantly less likely to require further anticonvulsants to control continuing seizures, 8/80 (10%) versus 21/80 (26%), RR 0.58 (95% CI 0.42 to 0.79). "
|
4. | Status Epilepticus (Complex Partial Status Epilepticus)
|
5. | Hysteria
|
|
Related Drugs and Biologics
Related Therapies and Procedures