Paragonimiasis

Infection with TREMATODA of the genus PARAGONIMUS.

Also Known As:

Paragonimus Infection; Paragonimus westermani Infection; Infection, Paragonimus; Infection, Paragonimus westermani; Infections, Paragonimus; Infections, Paragonimus westermani; Paragonimiases; Paragonimus Infections; Paragonimus westermani Infections

Networked: 300 relevant articles (22 outcomes, 27 trials/studies)

Relationship Network

Disease Context: Research Results

Infections: 526564
- Parasitic Diseases: 4870
  - Helminthiasis: 527
    - Trematode Infections: 111
      - Paragonimiasis: 300

Related Diseases

1.	Infections
2.	Tuberculosis (Tuberculoses)
3.	Clonorchiasis
4.	Fascioliasis
5.	Eosinophilia

Experts

1.	Kong, Yoon: 7 articles (01/2022 - 05/2002)
2.	Nawa, Yukifumi: 5 articles (01/2022 - 06/2002)
3.	Dekumyoy, Paron: 5 articles (05/2018 - 01/2005)
4.	Matsukura, S: 5 articles (11/2002 - 12/2000)
5.	Nawa, Y: 5 articles (11/2002 - 01/2001)
6.	Intapan, Pewpan M: 4 articles (01/2021 - 12/2005)
7.	Maleewong, Wanchai: 4 articles (01/2021 - 12/2005)
8.	Cui, Jing: 4 articles (07/2013 - 01/2003)
9.	Katoh, S: 4 articles (11/2002 - 12/2000)
10.	Mukae, H: 4 articles (11/2002 - 12/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Paragonimiasis:

1.	Praziquantel (Biltricide)FDA Link 01/01/2023 - "After praziquantel treatment, most of the children improved, and one child with cerebral paragonimiasis experienced sequelae. " 01/01/2016 - "Most patients with paragonimiasis are cured by standard praziquantel treatment. " 01/01/2011 - "Most patients with pleuropulmonary paragonimiasis can be cured by the initial single set of Praziquantel (PZQ) treatment. " 03/01/2022 - "After being diagnosed with pulmonary and hepatic paragonimiasis, he was treated with praziquantel and his condition improved without complications." 03/01/1989 - "Clinical field trials of praziquantel in pulmonary paragonimiasis due to Paragonimus uterobilateralis in endemic populations of the Igwun Basin, Nigeria."
2.	TriclabendazoleIBA 07/01/2003 - "Our findings show that both single-day treatment regimens of triclabendazole were highly effective in the treatment of pulmonary paragonimiasis and suggest that patients should be re-examined at 3 months to determine the need for repeat treatment." 12/01/2019 - "We present the case of a 7-year-old school patient, hospitalized with the diagnosis of pulmonary paragonimiasis, who had a favorable evolution after receiving treatment with triclabendazole. " 11/01/2003 - "To observe triclabendazole effect on Paragonimus skrjabini in experimentally infected rats,and to develop a new drug for treating paragonimiasis. " 11/01/2003 - "Triclabendazole in the treatment of Paragonimiasis skrjabini." 07/01/2003 - "Comparison of two single-day regimens of triclabendazole for the treatment of human pulmonary paragonimiasis."
3.	Chloroquine (Aralen)FDA LinkGeneric 01/01/1954 - "Preliminar observations on efficacy of chloroquine in treatment of paragonimiasis; a report of three cases." 11/01/1954 - "Chemotherapy of paragonimiasis; further observations on the efficacy of chloroquine." 12/01/1958 - "[Chloroquine therapy of paragonimiasis]." 03/01/1959 - "[OBSERVATIONS on the therapeutic value of chloroquine and chloroquine combined with emetine in the treatment of 160 cases of paragonimiasis]."
4.	AntigensIBA 02/01/2021 - "Our study has identified and localized antigens that are promising for serodiagnosis of human paragonimiasis." 07/01/1991 - "Studies on immunodiagnosis of human paragonimiasis and specific antigen of Paragonimus heterotremus." 01/01/1986 - "A preliminary study on the immunodiagnosis of paragonimiasis--the physico-chemical and immunological characteristics of the crude and partially purified antigens of Paragonimus westermani (Liaoning)." 06/01/1974 - "[Serological studies on Paragonimius uterobilateralis and other trematodal antigens with sera from paragonimiasis-patients from Nigeria (author's transl)]." 09/01/1963 - "[STUDIES ON THE PARAGONIMIASIS ANTIGEN RESPONSIBLE FOR THE SKIN REACTION]."
5.	Immunoglobulin G (IgG)IBA 12/01/1983 - "From the above results, it was inferred that the detection of Paragonimus-specific IgG antibogy by micro-ELISA was very much helpful in detecting the active cases as well as in proper evaluation of the endemicity of human paragonimiasis in a population. " 09/01/2015 - "Elevated serum IgG4 levels in two cases of paragonimiasis." 01/01/2007 - "Sera from patients with paragonimiasis showed antibody reactivity against rPwPmy, and IgG1 and IgG4 were predominant. " 06/01/2000 - "These results suggest that ESP secreted by PwNEM may be important in the control of effector functions of granulocytes stimulated with IgG in human paragonimiasis." 07/01/1995 - "Antibody isotypes, including IgG subclasses, in Ecuadorian patients with pulmonary paragonimiasis."
6.	ImmunosorbentsIBA 12/01/1989 - "[A diagnostic kit for rapid microenzyme linked immunosorbent assay of paragonimiasis]." 01/01/2021 - "We detected paragonimiasis cases by enzyme-linked immunosorbent assay (ELISA). " 06/01/2016 - "The diagnosis was confirmed based on a positive antibody test using enzyme-linked immunosorbent assay (ELISA) for paragonimiasis in the serum. " 01/01/2016 - "To obtain good compliance of people for the surveillance of paragonimiasis, an enzyme-linked immunosorbent assay (ELISA) for the diagnosis of paragonimiasis with unconcentrated urine samples was developed. " 01/01/2016 - "A tool for mass-screening of paragonimiasis: an enzyme-linked immunosorbent assay with urine samples."
7.	EnzymesIBA 03/01/1983 - "Immunodiagnosis of human paragonimiasis by an enzyme immunoassay." 03/01/1983 - "An enzyme immunoassay was applied to stepless antibody determination in sera from patients with paragonimiasis africanus, paragonimiasis uterobilateralis, paragonimiasis ecuadoriensis, other helminthic infestation, non parasitic diseases and healthy individuals. " 10/01/1996 - "An ELISA using the enzyme preparation not only had increased sensitivity to paragonimiasis westermani sera but also reduced cross-reactivity with the fascioliasis, onchocerciasis, and clonorchiasis sera to negligible levels. " 01/01/2021 - "We detected paragonimiasis cases by enzyme-linked immunosorbent assay (ELISA). " 06/01/2016 - "The diagnosis was confirmed based on a positive antibody test using enzyme-linked immunosorbent assay (ELISA) for paragonimiasis in the serum. "
8.	EmetineIBA 09/01/1962 - "[A case of paragonimiasis cured with emetine, thiasin and stibnal]." 12/01/2009 - "Kobayashi Harujiro(1884-1969), a leading zoologist and researcher of endemic disease for three decades in the Government General Hospital and Keijo Imperial University in colonial Korea, had used emetine while researching paragonimiasis, but he did not play a leading role in clinical trials with emetine injections, perhaps because he mainly researched the intermediary host. " 12/01/2009 - "Because of the danger emetine injections posed, the colonial government investigated only the actual condition of paragonimiasis, delaying the use of emetine injection. " 03/01/1959 - "[OBSERVATIONS on the therapeutic value of chloroquine and chloroquine combined with emetine in the treatment of 160 cases of paragonimiasis]." 12/01/2009 - "When Dr. Ikeda Masakata invented acid emetine to cure paragonimiasis in Manchuria in 1915, emetine treatment carried the risk of emetine poisoning such as fatigue, inappetence, heart failure, and death. "
9.	Bithionol (Bitin)IBA 11/01/2023 - "In the present study, antimicrobial drug screening conducted revealed that bithionol (BT), approved by the Food and Drug Administration and used as an anthelminthic drug for paragonimiasis, exhibited a synergistic antibacterial effect with COL. " 01/01/1987 - "In some definite paragonimiasis cases, the ELISA value was markedly reduced after drug-treatment with bithionol. " 01/01/1984 - "[Follow-up of 23 cases of paragonimiasis treated with bithionol]." 01/01/1984 - "On the other hand, bithionol proved to be a drug of choice for paragonimiasis. " 02/01/1983 - "[Clinical types and bitin treatment of paragonimiasis of the central nervous system--an analysis of 24 cases]."
10.	Complement System Proteins (Complement)IBA 03/01/1992 - "The intradermal paragonimiasis reaction, complement fixation, and Ouchterlony tests were not useful for diagnosis. " 12/01/1977 - "The passive haemagglutination and complement fixation test were suitable serological methods to indicate a Paragonimus infection in monkeys. " 12/01/1969 - "[Immuno-Diffusion And Complement-Fixation Test In Paragonimiasis Of Cat]" 01/01/1955 - "The value of complement fixation test and intradermal test in the diagnosis of paragonimiasis." 12/01/1969 - "In order to observe the complement fixation test and immuno-diffusion test of paragonimiasis, the sera taken at 10 days intervals up to 150 days from cats infected with Paragonimus westermani were examined by the above two immunological methods. "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 01/01/2011 - "Can pleuropulmonary paragonimiasis be cured by only the 1st set of chemotherapy? " 06/01/1974 - "[A Follow-Up Study To Evaluate The Efficacy Of Mass Chemotherapy For Control Of Paragonimiasis]" 01/01/2011 - "The objective of this study was to evaluate the clinical findings of patients with pleuropulmonary paragonimiasis who needed additional PZQ treatment after the 1st set chemotherapy. " 08/01/1962 - "[Studies on the chemotherapy of pulmonary paragonimiasis. " 01/01/1994 - "Diagnosis of cerebral paragonimiasis in its early active stage is important because curative chemotherapy is possible. "
2.	Therapeutics 01/01/2016 - "Pleuropulmonary paragonimiasis with migrated lesions cured by multiple therapies." 02/08/2017 - "Objective: To analyze the clinical, pathological and radiological characteristics of paragonimiasis in children for accurate diagnosis and therapy. " 03/01/1964 - "THE CLINICAL MANIFESTATIONS AND BETHIONOL THERAPY OF PARAGONIMIASIS IN SZECHUAN PROVINCE." 05/01/1953 - "Paragonimiasis: failure of nilodin in therapy and report of one case with urinary tract involvement." 11/01/2018 - "Furthermore, cases of paragonimiasis may be misdiagnosed as resistant tuberculosis (TB) because of the similar pulmonary symptoms and no remission after anti TB therapy. "
3.	Injections 12/01/2009 - "Kobayashi Harujiro(1884-1969), a leading zoologist and researcher of endemic disease for three decades in the Government General Hospital and Keijo Imperial University in colonial Korea, had used emetine while researching paragonimiasis, but he did not play a leading role in clinical trials with emetine injections, perhaps because he mainly researched the intermediary host. " 12/01/2009 - "Because of the danger emetine injections posed, the colonial government investigated only the actual condition of paragonimiasis, delaying the use of emetine injection. " 01/01/1994 - "We report a case of paragonimiasis diagnosed by fine-needle aspiration of a breast mass in a middle-aged Korean female with a history of breast silicone injections. "
4.	Aftercare (After-Treatment) 09/01/2006 - "Cutaneous paragonimiasis with flare up after treatment: a clinical case from Laos." 08/01/1981 - "The disappearance of precipitating bands of immunoelectrophoresis together with the disappearance of abnormal shawdows in chest X-ray after treatment gave a potent proof on assuring the cure of paragonimiasis." 01/01/2003 - "These patients underwent chest x-rays to assess radiological lesions due to paragonimiasis before and after treatment with Praziquantel. " 06/01/1964 - "Ten cases infected with Taenia saginata were treated with Bithionol, 2, 2' thiobis (4,6-dichlorophenol) which is well known as an excellent anthelminthhic against paragonimiasis and their follow-up studies were carried on within 3 to 12 months after treatment. " 03/01/1976 - "The complement fixation (CF) test was not suitable for serodiagnostic or seroepidemiologic studies nor for the assessment of the cure of African Paragonimiasis since antibodies persisted for at least one year after treatment. "
5.	Operating Tables 06/30/2011 - "In two of them, he performed cerebral hemispherectomy to control intractable convulsions when he found diffuse cerebral paragonimiasis and cerebral atrophy at the operating table. "