Extra-Adrenal Paraganglioma (Paraganglioma, Extra Adrenal)

Subscribe to Selected New Research on Extra-Adrenal Paraganglioma

92 relevant articles (1 outcomes, 2 trials/studies) found for this Disease

Description: A relatively rare, usually benign neoplasm originating in the chemoreceptor tissue of the CAROTID BODY; GLOMUS JUGULARE; GLOMUS TYPANICUM;, and AORTIC BODIES. It consists histologically of rounded or ovoid hyperchromatic cells that tend to be grouped in an alveolus-like pattern within a scant to moderate amount of fibrous stroma and a few large thin-walled vascular channels. (From Stedman, 27th ed)

Also Known As:

Paraganglioma, Extra Adrenal; Chemodectoma; Paraganglioma, Extra-Adrenal; Paraganglioma, Non-Chromaffin; Chemodectomas; Extra-Adrenal Paragangliomas; Non-Chromaffin Paraganglioma; Non-Chromaffin Paragangliomas; Nonchromaffin Paraganglioma; Nonchromaffin Paragangliomas; Paraganglioma, Non Chromaffin; Paragangliomas, Extra-Adrenal; Paragangliomas, Non-Chromaffin; Paragangliomas, Nonchromaffin; Paraganglioma, Nonchromaffin

Relationship Network

Disease Context: Research Results

Neoplasms: 387640

Neoplasms by Histologic Type: 1

Germ Cell and Embryonal Neoplasms: 2523

Neuroectodermal Tumors: 161

Neuroendocrine Tumors: 1055

Paraganglioma: 600

Extra-Adrenal Paraganglioma: 92

Carotid Body Tumor: 63

Glomus Jugulare Tumor: 27

Glomus Tympanicum Tumor: 4

Nerve Tissue Neoplasms: 1

Neuroectodermal Tumors: 161

Neuroendocrine Tumors: 1055

Paraganglioma: 600

Extra-Adrenal Paraganglioma: 92

Carotid Body Tumor: 63

Glomus Jugulare Tumor: 27

Glomus Tympanicum Tumor: 4

Related Diseases

1.	Carotid Body Tumor
2.	Chondroma (Enchondroma)
3.	Neoplasms (Cancer)
4.	Leiomyosarcoma
5.	Syndrome

Experts

1.	Fraile, M: 1 article (05/2006)
2.	Minoves, M: 1 article (05/2006)
3.	García, J R: 1 article (05/2006)
4.	Bassa, P: 1 article (05/2006)
5.	Schlegel, Wolfgang: 1 article (04/2004)
6.	Zabel, Angelika: 1 article (04/2004)
7.	Wannenmacher, Michael: 1 article (04/2004)
8.	Debus, Jürgen: 1 article (04/2004)
9.	Milker-Zabel, Stefanie: 1 article (04/2004)
10.	Schulz-Ertner, Daniela: 1 article (04/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Extra-Adrenal Paraganglioma:

1.	Doxorubicin (Adriamycin)FDA LinkGeneric 11/01/1998 - "CONCLUSIONS: A doxorubicin-streptozocin combination produced a temporary remission of this patient's multiple pulmonary chemodectomas." 06/01/1985 - "Twelve patients with advanced apudomas--six with carcinoid tumors, two with chemodectomas, two with pancreatic islet cell tumor, and one each of medullary carcinoma of the thyroid and paraganglioma of unknown primary--were treated with a combination of doxorubicin 50 mg/m2 and cisplatin 50 mg/m2 every 3 to 4 weeks" Order ALL the reference details at left...
2.	Streptozocin (Streptozotocin)FDA Link 11/01/1998 - "CONCLUSIONS: A doxorubicin-streptozocin combination produced a temporary remission of this patient's multiple pulmonary chemodectomas." Order ALL the reference details at left...
3.	Phosphopyruvate Hydratase (Enolase)IBA 09/25/1993 - "METHODS: Nine extra-adrenal paragangliomas (three jugulo-tympanic, four carotid-body tumors, and two retroperitoneal) were studied by conventional histological criteria, and also by chromogranin A and neuron-specific enolase (NSE) immunohistochemical staining for the study of chief cells, and S-100 as a marker of sustentacular cells" 04/01/2003 - "In an immunohistochemical study of 25 canine chemodectomas, 17 tumours were stained with antisera to neurone specific enolase and the same number were stained for synaptophysin; a single tumour was stained for S100" Order ALL the reference details at left...
4.	Chromogranin AIBA 07/01/1998 - "Pheochromocytomas (7/7), chemodectomas (5/7), islet cell carcinomas (2/6), pituitary adenomas (4/6), parathyroid adenomas (3/7), and a C-cell carcinoma (1/1) stained positive for chromogranin A" 09/25/1993 - "CONCLUSIONS: The histopathologic signs implying worse prognosis in extra-adrenal paragangliomas are a decrease in chromogranin A and S-100 immunoreactivity and a rate of cell proliferation of 5% or greater, or a number of cells stained for proliferating cell nuclear antigen greater than 50 in 10 high-power field." 09/25/1993 - "METHODS: Nine extra-adrenal paragangliomas (three jugulo-tympanic, four carotid-body tumors, and two retroperitoneal) were studied by conventional histological criteria, and also by chromogranin A and neuron-specific enolase (NSE) immunohistochemical staining for the study of chief cells, and S-100 as a marker of sustentacular cells" 04/01/1994 - "Immunohistochemical demonstration of chromogranin A, chromogranin B, and secretogranin II in extra-adrenal paragangliomas." 04/01/1994 - "Twelve sympathetic and 14 parasympathetic extra-adrenal paragangliomas were investigated immunohistochemically with antibodies against chromogranin A, chromogranin B, and secretogranin II. In sympathetic paragangliomas chromogranin A was found in 12/12 and chromogranin B in 11/12 tumors in almost all chief cells (the remaining tumor was focally chromogranin B positive), whereas secretogranin II was immunolocalized in the majority of chief cells in 5/12, in a focal distribution in 3/12, and only in a few scattered tumor cells in 3/12 cases" Order ALL the reference details at left...
5.	SynaptophysinIBA 12/01/1987 - "Synaptophysin (protein p38) immunoreactivity has been detected immunohistochemically in neuroendocrine cells of the human adrenal medulla, carotid body, skin, pituitary, thyroid, lung, pancreas and gastrointestinal mucosa as well as in 87 out of 93 neuroendocrine tumours investigated, including pheochromocytomas, chromaffin and non-chromaffin paragangliomas, ganglioneuromas, pituitary adenomas, thyroid medullary carcinomas, parathyroid adenomas, lung carcinoids and neuroendocrine carcinomas, pancreatic and gut endocrine tumours and cutaneous merkelomas" 04/01/2003 - "In an immunohistochemical study of 25 canine chemodectomas, 17 tumours were stained with antisera to neurone specific enolase and the same number were stained for synaptophysin; a single tumour was stained for S100" Order ALL the reference details at left...
6.	Immune Sera (Antisera)IBA 04/01/2003 - "In an immunohistochemical study of 25 canine chemodectomas, 17 tumours were stained with antisera to neurone specific enolase and the same number were stained for synaptophysin; a single tumour was stained for S100" Order ALL the reference details at left...
7.	Triad FDA Link 12/01/1986 - "The association of these two tumours and extra-adrenal paraganglioma has been described as a triad by Carney" 08/01/2008 - "The Carney triad is the non-familial addociation of gastric stromal tumours (GISTs), pulmonar chondromas and extra-adrenal paragangliomas" 07/01/2007 - "Carney triad is a rare non-hereditary condition affecting young females and characterized by metachronous or synchronous occurrence of epithelioid gastrointestinal stromal tumours (GISTs), pulmonary chondroma and extra-adrenal paraganglioma" 03/01/1987 - "Gastric autonomic nerve (GAN) tumor and extra-adrenal paraganglioma in Carney's triad" 12/01/2007 - "The Carney triad is the clinical association of gastric stromal sarcomas, pulmonary cartilaginous tumors, and extra-adrenal paragangliomas" Order ALL the reference details at left...
8.	3-Iodobenzylguanidine (Iobenguane)IBA 03/01/1995 - "Asymmetric submandibular gland uptake of I-123 MIBG mimicking a chemodectoma." 06/01/1994 - "In patients with chemodectomas, SPECT imaging of the neck may be necessary to distinguish normal salivary gland uptake from tumoral uptake of MIBG" 06/01/1994 - "The authors present a case of a patient with a known history of chemodectoma, imaged with I-123 MIBG to rule out recurrent disease" 06/01/1987 - "Iodinated meta-iodobenzylguanidine (MIBG) scanning is a safe non-invasive method for locating extra-adrenal paragangliomas" 12/01/1995 - "Chemodectoma is a rare, slow growing neoplasm with local aggressiveness and a high rate of residuals after surgery, arising from paraganglionic tissue (neural crest) and therefore able to take up Metaiodobenzylguanidine (MIBG)" Order ALL the reference details at left...
9.	Norepinephrine (Noradrenaline)FDA LinkGeneric 01/01/1981 - "Intrathoracic chemodectoma with noradrenaline secretion." 07/05/1965 - "A NOREPINEPHRINE-SECRETING GLOMIC TISSUE TUMOR (CHEMODECTOMA)." 07/01/1990 - "One patient had a norepinephrine secreting chemodectoma and one had a dopamine secreting chemodectoma" 08/01/1962 - "Noradrenaline--adrenaline producing nonchromaffin paraganglioma." Order ALL the reference details at left...
10.	CatecholaminesIBA 01/01/1996 - "Chemodectomas only very infrequently produce catecholamines (1 to 10%)" 01/01/1996 - "Two cases of carotid glomus chemodectomas with production of catecholamines are reported" 03/01/1986 - "A glomus jugulare chemodectoma producing catecholamines" 05/01/2008 - "Immunohistochemistry and silver staining did not allow further differentiation of the tumor, and the diagnosis remains consistent with either a chromaffin paraganglioma or a nonchromaffin paraganglioma (chemodectoma) with some production of catecholamines" 10/11/1986 - "Childhood retroperitoneal extra-adrenal paraganglioma, secretor of catecholamines, thyrocalcitonin and gastrin" Order ALL the reference details at left...

Therapies and Procedures

1.	Conformal Radiotherapy 04/01/2004 - "PURPOSE: To evaluate the role of fractionated stereotactic conformal radiotherapy (FSRT) as a noninvasive method in the management of large chemodectomas of the skull base" 04/01/2004 - "Fractionated stereotactic conformal radiotherapy in the management of large chemodectomas of the skull base." 04/01/2004 - "CONCLUSION: Fractionated stereotactic conformal radiotherapy is an effective and well-tolerated noninvasive treatment for chemodectomas, with excellent tumor control rates and a low risk of morbidity" Order ALL the reference details at left...
2.	X-Ray Therapy 01/01/1985 - "Results of roentgenotherapy of chemodectoma of the ear]" Order ALL the reference details at left...
3.	Resuscitation 03/01/1979 - "Resuscitation problems arising from the surgical treatment of chemodectomas in the carotid fork (author's transl)]" Order ALL the reference details at left...
4.	Laryngectomy 04/01/1988 - "A 53-year-old lady underwent a total laryngectomy in May 1984 for an extensive chemodectoma of the larynx" 04/01/1988 - "A 70-year-old man underwent a laryngectomy in April 1984 for a tumor diagnosed as a squamous cell carcinoma but which postoperatively proved to be a chemodectoma" Order ALL the reference details at left...
5.	Laparotomy 06/01/1982 - "A single case of an extra-adrenal paraganglioma removed at laparotomy from the falciform ligament of a 16 year-old girl is reported" Order ALL the reference details at left...

Research Interface

Rapidly retrieve summaries of all the evidence for any disease in seconds. Save hours of search and analysis time. CureHunter is unlike any "search engine" you have ever used. Where standard "search engines" produce lists of links, CureHunter quantifies evidence, extracts it from the literature and calculates a result you can use to immediately facilitate evidence based decision making in Real Clinical Time.

Unlimited Disease, Drug and Therapy Search
2 clicks from Disease to Drug to Evidence
Trial References
All the Positive Outcomes
Detailed Relationship Timeline Charts
Full Article Reference Details
Includes Mobile Interface Subscription
One-click to FDA Products/Patents
Request Institution License Details >>

Price:

$490.00 access via web interface
1 year subscription

Proceed to Checkout >>

Mobile Interface

Retrieve summaries of all the evidence for any disease from your Mobile Phone or PDA. Accelerate decision making in the field. Speed up your study of new drug and disease domains. Refresh your knowledge on the road.

Access from any web enabled PDA or Phone
Trial references
All the Positive Outcomes
Drug and Therapy searches
Full Article Reference Details
Try Mobile Interface >>

Price:

$45.00 access via "curehunter.com/m"
1 year subscription

Proceed to Checkout >>