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Pancuronium (Pavulon)

A bis-quaternary steroid that is a competitive nicotinic antagonist. As a neuromuscular blocking agent it is more potent than CURARE but has less effect on the circulatory system and on histamine release.
Also Known As:
Pavulon; Organon Brand of Pancuronium Bromide; Organon Teknika Brand of Pancuronium Bromide; Pancuronium Bromide; Pancuronium Curamed; Pancuronium Organon; Schwabe Brand of Pancuronium Bromide; Bromide, Pancuronium; Piperidinium, 1,1'-((2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetyloxy)androstane-2,16-diyl)bis(1-methyl-)
Networked: 450 relevant articles (15 outcomes, 25 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1. Pitsillides, Andrew A: 2 articles (04/2006 - 08/2003)
2. Cools, F: 2 articles (01/2005 - 01/2000)
3. Offringa, M: 2 articles (01/2005 - 01/2000)
4. Szokol, Joseph W: 2 articles (01/2004 - 05/2003)
5. Avram, Michael J: 2 articles (01/2004 - 05/2003)
6. Vender, Jeffery S: 2 articles (01/2004 - 05/2003)
7. Murphy, Glenn S: 2 articles (01/2004 - 05/2003)
8. Marymont, Jesse H: 2 articles (01/2004 - 05/2003)
9. Sugumar, Bina: 1 article (01/2016)
10. Cappello, Paola: 1 article (01/2016)

Related Diseases

1. Paralysis (Palsy)
09/30/1976 - "The half-life of the beta-phase varied between 89.5 and 161.5 min. The apparent volume of distribution of the central compartment ranged from 62.9 to145.5 ml/kg and the plasma clearance from 57.6 to 187.3 ml/min. At the first sign of recovery from neuro-muscular blockade the mean pancuronium plasma level was found to be 0.218 mcg/ml. The mean duration of action as measured from time of onset of paralysis to 20% recovery was 83.4 min with the plasma level at 20% being 0.169 mcg/ml corresponding to 45.4% of dose remaining to be eliminated from the body."
07/01/1995 - "To study the effects of muscle paralysis on joint mobility, we compared eight premature infants treated with pancuronium bromide with a control group. "
05/01/1985 - "We conclude that 1) although tonic inspiratory activity of chest wall muscles exists, it does not significantly affect the chest wall relaxation characteristics in trained subjects; 2) submaximal paralysis produced by pancuronium bromide is likely to modify either spinal attitude or the distribution of blood between extremities and the thorax; these effects may account for the changes in FRC in other studies."
12/01/1984 - "The purpose of this study was to evaluate cerebral blood flow and metabolism following pancuronium bromide paralysis in healthy newborn lambs. "
07/01/2011 - "We found that pancuronium-induced paralysis did not affect the electrophysiological properties of ongoing cortical activity and its perturbation evoked by visual and tactile stimuli. "
2. Bradycardia
3. Anoxia (Hypoxia)
4. Renal Insufficiency (Renal Failure)
5. Seizures (Seizure)

Related Drugs and Biologics

1. Succinylcholine (Suxamethonium Chloride)
2. Midazolam (Versed)
3. Fentanyl (Sublimaze)
4. Atracurium (Tracrium)
5. Halothane (Fluothane)
6. Neostigmine (Neostigmine Bromide)
7. metocurine (Metubine)
8. Atropine (Hyoscyamine)
9. Alcuronium (Alcuronium Chloride)
10. Propofol (Diprivan)

Related Therapies and Procedures

1. Artificial Respiration (Mechanical Ventilation)
2. Anesthesia
3. Ligation
4. Tracheostomy
5. Electrodes (Electrode)