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Pancreatic Polypeptide (Pancreatic Polypeptide (PP))

A 36-amino acid pancreatic hormone that is secreted mainly by endocrine cells found at the periphery of the ISLETS OF LANGERHANS and adjacent to cells containing SOMATOSTATIN and GLUCAGON. Pancreatic polypeptide (PP), when administered peripherally, can suppress gastric secretion, gastric emptying, pancreatic enzyme secretion, and appetite. A lack of pancreatic polypeptide (PP) has been associated with OBESITY in rats and mice.
Also Known As:
Pancreatic Polypeptide (PP); Pancreatic Polypeptide Hormone; Pancreatic Prohormone
Networked: 680 relevant articles (6 outcomes, 53 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Davis, Stephen N: 5 articles (01/2015 - 07/2004)
2. Cryer, Philip E: 5 articles (04/2004 - 04/2002)
3. Davis, S N: 5 articles (06/2001 - 01/2000)
4. Bloom, Stephen R: 4 articles (12/2011 - 01/2008)
5. Banarer, Salomon: 4 articles (05/2003 - 04/2002)
6. Tate, D: 4 articles (06/2001 - 01/2000)
7. Sainsbury, Amanda: 3 articles (12/2015 - 05/2002)
8. Ertl, Andrew C: 3 articles (04/2010 - 07/2004)
9. Tate, Donna B: 3 articles (04/2010 - 09/2008)
10. McGregor, Veronica P: 3 articles (05/2002 - 04/2002)

Related Diseases

1. Neoplasms (Cancer)
2. Chronic Pancreatitis
3. Ganglion Cysts (Ganglion)
4. Multiple Endocrine Neoplasia (Multiple Endocrine Adenomatosis)
02/05/1982 - "Multiple endocrine adenomatosis type I. Occurrence in an octogenarian with high levels of circulating pancreatic polypeptide."
12/01/1983 - "Pancreatic polypeptide update: its roles in detection of the trait for multiple endocrine adenopathy syndrome, type I and pancreatic polypeptide-secreting tumors."
08/01/1981 - "An apparently complete remission of metastases in the liver from a resected pure pancreatic polypeptide apudoma occurred following intra-arterial and intravenous administration of streptozocin to a patient in a family with multiple endocrine adenopathy, type 1. Plasma concentrations of human pancreatic polypeptide constitute an excellent marker system for the detection and assessment of tumor status before and after surgical and streptozocin therapy."
01/01/1980 - "Elevated basal and responsive (after a meal) plasma concentrations of a relatively new candidate-hormone, human pancreatic polypeptide (hPP), were associated with pancreatic apudoma tumors in three asymptomatic patients with multiple endocrine adenopathies, type I. Two of these patients had excision of the tumors that resulted in normal plasma hPP concentrations postoperatively. "
06/01/2002 - "Ten cases of normal pancreatic tissue, two cases of nesidioblastosis, five insulin-producing tumours and one case of multiple endocrine neoplasia 1 syndrome, containing an insulin-, a somatostatin- and several glucagon-producing tumours, as well as tiny foci of endocrine dysplasia with different predominance of the secreted hormones (mainly glucagon and pancreatic polypeptide) were included in the study. "
5. Body Weight (Weight, Body)

Related Drugs and Biologics

1. Insulin (Novolin)
2. Somatostatin (Somatotropin Release-Inhibiting Factor)
3. Phosphopyruvate Hydratase (Enolase)
4. Glucose (Dextrose)
5. Blood Glucose (Blood Sugar)
6. S100 Proteins (S 100 Protein)
7. Streptozocin (Streptozotocin)
8. Glucagon (Glukagon)
9. Gastrins
10. Hormones

Related Therapies and Procedures

1. Subcutaneous Infusions
2. Intravenous Injections
3. Electroacupuncture
4. Truncal Vagotomy
5. Vagotomy