Pancreatic Cyst

A true cyst of the PANCREAS, distinguished from the much more common PANCREATIC PSEUDOCYST by possessing a lining of mucous EPITHELIUM. Pancreatic cysts are categorized as congenital, retention, neoplastic, parasitic, enterogenous, or dermoid. Congenital cysts occur more frequently as solitary cysts but may be multiple. Retention cysts are gross enlargements of PANCREATIC DUCTS secondary to ductal obstruction. (From Bockus Gastroenterology, 4th ed, p4145)

Also Known As:

Networked: 498 relevant articles (18 outcomes, 59 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Cysts
2.	Pancreatitis
3.	Pathologic Constriction (Stenosis)
4.	Abdominal Pain (Pain, Abdominal)
5.	Abscess

Experts

1.	Schmidt, C Max: 15 articles (11/2022 - 02/2008)
2.	Hruban, Ralph H: 14 articles (01/2018 - 01/2011)
3.	Yip-Schneider, Michele T: 11 articles (02/2021 - 02/2008)
4.	Lennon, Anne Marie: 10 articles (01/2022 - 07/2013)
5.	Pitman, Martha B: 10 articles (05/2021 - 01/2014)
6.	Brugge, William R: 10 articles (01/2018 - 05/2009)
7.	Goggins, Michael: 8 articles (01/2022 - 02/2008)
8.	Wu, Huangbing: 8 articles (02/2021 - 04/2014)
9.	Lee, Linda S: 8 articles (01/2021 - 01/2012)
10.	Wolfgang, Christopher L: 8 articles (11/2019 - 09/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pancreatic Cyst:

1.	Ethanol (Ethyl Alcohol)IBA 05/01/2015 - "We undertook a meta-analysis and systematic review to assess the overall safety and efficacy of EUS-guided ethanol ablation of pancreatic cysts. " 05/01/2015 - "Data was extracted from seven studies (n = 152) of EUS-guided ethanol ablation of pancreatic cysts, which met the inclusion criteria. " 10/01/2010 - "In a previously reported trial, we found that CT scanning documented pancreatic cyst resolution in 12 patients (33%) after one (n = 6) or two (n = 6) ethanol lavages. " 10/01/2010 - "This study involved 12 patients with 1-to-5-cm, unilocular, pancreatic cysts that had previously resolved after ethanol lavage. " 05/01/2015 - "EUS-guided ethanol ablation may be a safe alternative treatment modality for pancreatic cysts, with acceptable intraprocedural and postprocedural complications. "
2.	Paclitaxel (Taxol)FDA LinkGeneric 01/01/2019 - "To evaluate the safety and efficacy of EUS-guided pancreatic cyst ablation with alcohol lavage or paclitaxel-based regimens. " 12/01/2022 - "Early phase trial of intracystic injection of large surface area microparticle paclitaxel for treatment of mucinous pancreatic cysts." 01/01/2019 - "A systematic review of computerized bibliographic databases was carried out for studies of EUS-guided pancreatic cyst ablation with alcohol lavage or paclitaxel-based regimens from January 1980 to February 2018. " 11/01/2019 - "Response to: 'The efficacy and safety of endoscopic ultrasound-guided ablation of pancreatic cysts with alcohol and paclitaxel: a systematic review'." 10/01/2019 - "Clinical outcomes of endoscopic ultrasound-guided ablation of pancreatic cysts with alcohol and paclitaxel."
3.	Biomarkers (Surrogate Marker)IBA 01/01/2019 - "Next generation sequencing of the cellular and liquid fraction of pancreatic cyst fluid supports discrimination of IPMN from pseudocysts and reveals cases with multiple mutated driver clones: First findings from the prospective ZYSTEUS biomarker study." 07/24/2017 - "This study aimed to provide an aid based on biological markers for the preoperative management of patients with pancreatic cysts. " 09/01/2014 - "Incremental improvements in pancreatic cyst diagnosis have occurred with new biomarkers and endoscopic tools requiring validation in large-scale studies." 08/01/2013 - "In this small single-center study, miRs are potential pancreatic cyst fluid diagnostic biomarkers. " 05/06/2011 - "Results from this study indicate that proteomic analysis of cyst fluid could provide reliable candidates for developing new biomarkers for the preoperative management of malignant and premalignant pancreatic cysts."
4.	AmylasesFDA Link 04/01/2017 - "This study reports on the value of ancillary tests, amylase and carcinoembryonic, in the evaluation and management of patients with negative and non-diagnostic pancreatic cysts. " 02/01/2013 - "Mean amylase levels in benign lesions (27825.7±91.9 U/l) were higher compared with malignant pancreatic cysts (8359.2±32.7 U/l; P<0.05). " 10/01/2009 - "442 pancreatic cyst fluids were tested for CEA, CA19-9, and amylase. " 03/01/1968 - "[Blood amylase in patients with pancreatic cyst]." 06/01/2008 - "Subsequently, the patient's abdominal pain improved, the pancreatic cyst disappeared, and the serum amylase level normalized. "
5.	Glucose (Dextrose)FDA LinkGeneric 10/01/2021 - "Low pancreatic cyst fluid glucose was associated with a high sensitivity and specificity with significantly improved diagnostic accuracy compared with CEA alone for the diagnosis of mucinous versus nonmucinous pancreatic cystic lesions." 01/01/2022 - "Multiple databases were searched and studies that reported on the utility of intracystic glucose levels in diagnosing mucinous pancreatic cysts were analyzed. " 01/01/2020 - "The aim of the study was to confirm the diagnostic yield of intracystic glucose in the diagnosis of pancreatic cyst subtypes. " 06/01/2015 - "A previous metabolomic study showed cyst fluid glucose as a potential marker to differentiate mucinous from non-mucinous pancreatic cysts. " 07/01/2023 - "In this French multicenter study, data of consecutive patients who underwent fine-needle aspiration of pancreatic cyst with intracyst glucose assay between 2018 and 2022 were retrospectively reviewed. "
6.	SteroidsIBA 01/01/2016 - "However, clinicians must be alert for atypical pancreatic cysts, such as multilocular cysts or cysts without obvious steroid response." 01/01/2016 - "We aimed to see the incidence and steroid response of pancreatic cysts and the features of cysts without proper response in cases with AIP. " 06/01/2009 - "Oral steroid therapy resulted in reduced pancreatic swelling, complete disappearance of the pancreatic cyst, and an improvement in biliary stenosis. " 05/01/2023 - "Steroid therapy has an acceptable role as the initial treatment in autoimmune pancreatitis patients with pancreatic cyst formation: Based on a Japanese nationwide study." 09/01/2008 - "Rapid disappearance of a pancreatic cyst after steroid therapy in a patient with autoimmune pancreatitis."
7.	Sclerosing Solutions (Sclerosing Agents)IBA 08/01/2020 - "All clinical studies examining the safety and efficacy of EUS-guided pancreatic cyst ablation with radiofrequency, sclerosants, ethanol, chemotherapeutics or a combination hereof were included. "
8.	SolutionsIBA 06/01/2003 - "Gussenbauer's procedure was a significant advance, representing a safe and effective solution to the pancreatic cyst problem. " 11/01/2011 - "Although rare, pancreatic cysts of type II may be unsuitable for internal drainage operations so that resection of the effected part of the pancreas could be a much better solution than external drainage."
9.	PlasticsIBA 07/01/2022 - "Therefore, we aimed to describe four pediatric cases of the pseudo-pancreatic cyst treated successfully with EUS-guided cysto-gastrostomy using plastic stents. "
10.	Ceftriaxone (Ceftriaxon)FDA LinkGeneric 01/01/2017 - "Single-dose intra-procedural ceftriaxone during endoscopic ultrasound fine-needle aspiration of pancreatic cysts is safe and effective: results from a single tertiary center."

Therapies and Procedures

1.	Therapeutics 05/01/1960 - "[Experimental studies on the therapy of pancreatic cysts]." 05/01/2020 - "Although most cystic lesions are benign, the malignant potential of several types of pancreatic cysts makes accurate classification vital to directing therapy. " 01/01/2017 - "Pancreatic Cysts: Controversies, Advances, Diagnoses, and Therapies." 10/01/2015 - "Endoscopic ultrasound-guided ablation therapy for pancreatic cysts." 07/01/2011 - "To assess the impact of antimicrobial therapy for prophylaxis during EUS-FNA of pancreatic cysts. "
2.	Lasers (Laser) 01/01/2020 - "Our meta-analysis speaks in favor of the use of needle-based confocal laser endomicroscopy as a safe and effective tool in the diagnostic algorithm of pancreatic cysts." 05/01/2015 - "Diagnosis of pancreatic cysts: EUS-guided, through-the-needle confocal laser-induced endomicroscopy and cystoscopy trial: DETECT study." 02/02/2023 - "Advances in endoscopic techniques (confocal laser endomicroscopy, microforceps biopsy) can provide a definitive diagnosis of pancreatic cysts in some cases; however, the use of these techniques involves a higher risk of adverse events." 01/01/2020 - "Needle-based confocal laser endomicroscopy in pancreatic cysts: a meta-analysis." 01/01/2019 - "Pancreatic Cysts: Diagnostic Role of EUS-Guided Microforceps Biopsy and Confocal Laser Endomicroscopy."
3.	Punctures 08/01/2015 - "In 83 patients operative interventions were performed, and in 1--positive results were achieved after pancreatic cyst puncture under ultrasonographic control. " 01/01/2007 - "Aspiration puncture method was effective at 59% cases that permitted to reduce the number of external and internal drainage operations at the patients with false pancreatic cysts." 01/01/2007 - "Results of treatment of 39 patients with false pancreatic cysts with fine needle aspiration punctures are analyzed. " 01/01/2007 - "[Puncture method for the treatment of postnecrotic pancreatic cysts]." 11/01/2002 - "Basing on accumulated experience the authors recommend to perform puncture-cathetherizational intervention under ultrasonic investigation and computeric tomography control, when nonformated or complicated pancreatic cyst is present; in the treatment of uncomplicated nonformated pancreatic cyst the operation of internal drainage, using different organs, stomach, duodenum, small intestine, constitutes the method of choice. "
4.	Stents 04/01/1996 - "Of the two unsuccessful insertions, one proceeded to longitudinal pancreato-jejunostomy and in the other a stent was inserted at distal pancreatic cyst-jejunostomy. " 05/01/2014 - "We evaluated the frequency and effectiveness of endoscopic (biliary or pancreatic sphincterotomy, biliary or pancreatic stent placement) and surgical (pancreatic cyst removal, pancreatic drainage procedure, pancreatic resection, surgical sphincterotomy) therapies. " 03/01/1990 - "The authors also worked out recommendations for a choice of instruments for prolonged external transcutaneous drainage of pancreatic cysts and abscesses, cleansing of the cavity and its sclerosing, inoperative cystogastrostomy between a cyst and a stomach stent." 01/01/2021 - "We report the case of a 63-year-old white man who, 3 days after stent removal of endoscopic drainage of pancreatic cysts, developed a penile necrosis due to purpura fulminans (PF) that has been misdiagnosed as Fournier's gangrene. " 01/01/2008 - "For localizing diagnosis of these small and multiple pancreatic cysts, we placed an endoscopic pancreatic stent (EPS), and MDCT with injection of CO2 via EPS was examined for the virtual CO2 pancreatography, consisting of OsiriX software system employing 3D virtual anatomic reconstruction with CO2 gas as a negative contrast agent. "
5.	Surgical Instruments (Clip) 01/01/2018 - "Pancreatic cyst biopsy: Improvement in diagnosis with micro forceps biopsy." 10/01/2023 - "Next-generation sequencing of pancreatic cyst wall specimens obtained using micro-forceps for improving diagnostic accuracy." 11/01/2019 - "A novel microbiopsy forceps used during endoscopic ultrasound examinations offers new opportunities for histological examination of tissue from pancreatic cysts as well as next-generation sequencing. " 11/01/2018 - "Recently, a through-the-needle microbiopsy forceps has become available, enabling procurement of EUS-guided histological specimens from the pancreatic cyst wall. " 01/01/2018 - "Beyond Pancreatic Cyst Epithelium: Evidence of Ovarian-Like Stroma in EUS-Guided Through-the-Needle Micro-Forceps Biopsy Specimens."