Pancoast Syndrome

A condition caused by an apical lung tumor (Pancoast tumor) with involvement of the nearby vertebral column and the BRACHIAL PLEXUS. Symptoms include pain in the shoulder and the arm, and atrophy of the hand.

Also Known As:

Networked: 69 relevant articles (3 outcomes, 2 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pain (Aches)
2.	Neoplasms (Cancer)
3.	Chronic Pain
4.	Carcinoma (Carcinomatosis)
5.	Hyperthermia

Experts

1.	Jones, David R: 3 articles (05/2013 - 01/2003)
2.	Nosotti, Mario: 2 articles (11/2016 - 04/2016)
3.	Palleschi, Alessandro: 2 articles (11/2016 - 04/2016)
4.	Rosso, Lorenzo: 2 articles (11/2016 - 04/2016)
5.	Detterbeck, Frank C: 2 articles (05/2013 - 01/2003)
6.	Larner, James M: 2 articles (05/2013 - 09/2007)
7.	Acharya, Achyut Bhakta: 1 article (02/2022)
8.	Bhatta, Narendra: 1 article (02/2022)
9.	Katuwal, Srijan: 1 article (02/2022)
10.	Limbu, Sion Hangma: 1 article (02/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pancoast Syndrome:

1.	Opioid Analgesics (Opioids)IBA 11/07/2019 - "The chronic pain associated with Pancoast tumor, which was difficult to treat with opioids and other medications, was effectively treated with a high-thoracic erector spinae plane block (ESPB). "
2.	alpha-Fetoproteins (alpha-Fetoprotein)IBA 03/01/2001 - "Further evaluation revealed an increased level of serum alpha-fetoprotein (24278 ng/ml), cryptogenic liver cirrhosis and primary hepatocellular carcinoma with protruding T3 vertebra metastasis that resulted in Pancoast's syndrome. " 08/01/2012 - "A 48-year-old male patient presented with a Pancoast tumor of the right lung and a serum alpha-fetoprotein (αFP) at 39,000 ng/ml. Alpha-fetoprotein is a tumor marker found elevated in patients with hepatocellular carcinoma (HCC), germ cell or stromal tumors of the ovary and nonseminomatous testicular cancer. " 12/15/1989 - "We report a patient with Pancoast syndrome in whom a biopsy specimen of a cervical mass at first thought to be anaplastic carcinoma was found to stain positively for leukocyte common antigen and negatively for keratin, epithelial membrane antigen, and alpha-fetoprotein. "
3.	Morphine (MS Contin)FDA LinkGeneric 01/01/1992 - "Here are two clinical reports: the first case with cervical epidural analgesia by ambulatory autoadministration device (Patient control analgesia), the other one with intrathecal in C7-T1 catheter with port access in which morphine was injected every 24 hours resulting in efficient analgesia, in metastatic Pancoast's syndrome. " 09/01/1989 - "The long-term, epidural administration of morphine and marcaine (bupivacaine) in 12 patients suffering from bronchogenic carcinoma of the pulmonary apex and consequent Pancoast's syndrome has been examined. " 09/01/1989 - "[Morphine combined with marcaine in long-term epidural analgesia in patients with Pancoast's syndrome caused by bronchogenic carcinoma of the apex of the lung]."
4.	Analgesics (Analgesic Drugs)IBA 11/01/1981 - "[Pancoast's syndrome from the analgesic viewpoint. " 04/01/1985 - "Cordotomy alone or, as necessary, in conjunction with analgesic drugs afforded complete pain control in 34/45 patients (75%) with Pancoast syndrome and in 50/58 patients (86%) with thoracic pain. "
5.	Phenol (Carbolic Acid)FDA Link 11/01/1980 - "Brachial plexus block with phenol for painful arm associated with Pancoast's syndrome."
6.	Mucin-1 (CA 15-3 Antigen)IBA 12/15/1989 - "We report a patient with Pancoast syndrome in whom a biopsy specimen of a cervical mass at first thought to be anaplastic carcinoma was found to stain positively for leukocyte common antigen and negatively for keratin, epithelial membrane antigen, and alpha-fetoprotein. "
7.	Leukocyte Common Antigens (CD45 Antigen)IBA 12/15/1989 - "We report a patient with Pancoast syndrome in whom a biopsy specimen of a cervical mass at first thought to be anaplastic carcinoma was found to stain positively for leukocyte common antigen and negatively for keratin, epithelial membrane antigen, and alpha-fetoprotein. "
8.	Paclitaxel (Taxol)FDA LinkGeneric 11/01/2004 - "Elimination of Pancoast tumor by carboplatin, paclitaxel, and concurrent radiation." 11/01/2004 - "Preoperative chemoradiotherapy with carboplatin (AUC 1.5), paclitaxel (40 mg/m2), and concurrent extracorporeal radiation (40 Gy) was used to treat a Pancoast tumor (clinical T3N0M0), without causing adverse events. "
9.	Carboplatin (JM8)FDA LinkGeneric 11/01/2004 - "Elimination of Pancoast tumor by carboplatin, paclitaxel, and concurrent radiation." 11/01/2004 - "Preoperative chemoradiotherapy with carboplatin (AUC 1.5), paclitaxel (40 mg/m2), and concurrent extracorporeal radiation (40 Gy) was used to treat a Pancoast tumor (clinical T3N0M0), without causing adverse events. "
10.	Vasopressins (Vasopressin)IBA 11/01/2013 - "The key clinical features in this case are to make the diagnosis apical lung cancer (Pancoast tumor) in a patient with brachial plexopathy and to recognize the association between syndrome of inappropriate secretion of antidiuretic hormone (SIADH) as a paraneoplastic syndrome and non-small cell lung cancer (NSCLC). "

Therapies and Procedures

1.	Radiotherapy 01/01/2012 - "Eventually, the patient was referred to the radiotherapy ward for treatment of Pancoast tumor. " 05/01/1993 - "[The value of radiotherapy in the treatment of Pancoast tumor of the lung]." 08/01/1991 - "Pancoast tumor: radiation therapy alone versus preoperative radiation therapy and surgery." 01/01/1990 - "If a Pancoast tumor is present, radiotherapy alone obtains a similar result as preoperative irradiation followed by resection. " 09/01/1979 - "Pancoast tumor: the value of high dose radiation therapy."
2.	Chemoradiotherapy 08/01/2023 - "The patient was managed with palliative chemoradiotherapy for Pancoast syndrome. " 11/11/2016 - "We report a case of Pancoast tumor in a 57-year-old man, staged as cT3N0M0, that was treated with induction chemoradiotherapy prior to the hybrid surgical approach. " 05/01/2013 - "In patients with a Pancoast tumor, a multimodality approach appears to be optimal, involving chemoradiotherapy and surgical resection, provided that appropriate staging has been carried out. " 01/01/2010 - "[Complete resection of Pancoast tumor following induction chemoradiotherapy improves survival]." 09/01/2007 - "In patients with a Pancoast tumor, a multimodality approach seems to be optimal, involving chemoradiotherapy and surgical resection, provided appropriate staging has been conducted. "
3.	Cordotomy 09/01/2006 - "Cordotomy is very effective in pain treatment and it may produce complete abolishment of pain, especially in patients suffering from neoplastic invasion of the brachial plexus (Pancoast's syndrome) or lumbosacral plexus. " 10/01/2001 - "However, cordotomy is still a valuable operation for certain forms of cancer related pains (Pancoast's syndrome, breakthrough pain) which are relatively resistant to pharmacotherapy. " 04/01/1985 - "The authors analyse the results up to death in 103 followed-up patients undergoing unilateral percutaneous cervical cordotomy for persistent cervico-thoracic malignant pain (45 cases of Pancoast syndrome and 58 cases of thoracic pain associated with lung cancer or metastases). " 04/01/1985 - "Cordotomy alone or, as necessary, in conjunction with analgesic drugs afforded complete pain control in 34/45 patients (75%) with Pancoast syndrome and in 50/58 patients (86%) with thoracic pain. " 04/01/1985 - "Twenty (44%) of 45 patients with Pancoast syndrome were pain-free up to death as a result of cordotomy alone, while only 13/58 patients (22%) with thoracic pain were pain-free as a result of cordotomy alone owing to the very high incidence of mirror pain in this group of patients (42/58 patients, 72%) compared to those with Pancoast syndrome (14/45 patients, 31%). "
4.	Catheters 11/07/2019 - "T1 Erector Spinae Plane Block Catheter As a Novel Treatment Modality for Pancoast Tumor Pain." 01/01/1992 - "Here are two clinical reports: the first case with cervical epidural analgesia by ambulatory autoadministration device (Patient control analgesia), the other one with intrathecal in C7-T1 catheter with port access in which morphine was injected every 24 hours resulting in efficient analgesia, in metastatic Pancoast's syndrome. "
5.	Therapeutics 09/01/2006 - "Multimodality therapy for Pancoast tumor." 07/01/1998 - "The evolution of therapy in 105 patients with superior sulcus (Pancoast) tumor over the past 42 years was reviewed. " 07/01/1987 - "Twenty-one patients underwent combined therapy (irradiation and radical resection) for a Pancoast tumor at the Massachusetts General Hospital between 1976 and 1985. " 11/01/1977 - "Adjuvant preoperative or postoperative therapy of any type does not improve the results of surgery except in patients with Pancoast tumor. " 02/01/2009 - "This patient was successfully treated with concurrent chemoradiotherapy, which is suggested to be a useful therapy for Pancoast tumor."