|4.||Neoplasm Metastasis (Metastasis)
|5.||Compression Fractures (Compression Fracture)
|1.||Massari, Francesco: 4 articles (07/2008 - 01/2004)|
|2.||Masala, Salvatore: 4 articles (07/2008 - 01/2004)|
|3.||Simonetti, Giovanni: 4 articles (07/2008 - 01/2004)|
|4.||Nijensohn, Daniel E: 3 articles (12/2015 - 09/2014)|
|5.||Bruera, Eduardo: 3 articles (04/2015 - 07/2012)|
|6.||Uezono, Yasuhito: 3 articles (03/2015 - 03/2014)|
|7.||Ueno, Susumu: 3 articles (03/2015 - 03/2014)|
|8.||Okura, Dan: 3 articles (03/2015 - 03/2014)|
|9.||Yanagihara, Nobuyuki: 3 articles (03/2015 - 03/2014)|
|10.||Sata, Takeyoshi: 3 articles (03/2015 - 03/2014)|
|1.||Morphine (MS Contin)FDA LinkGeneric
02/01/2006 - "The use of intrathecal morphine has been effective with few complications for chronic intractable pain of both benign and malignant origins. "
03/01/2013 - "The Prometra pump demonstrated accurate drug delivery throughout the study and provides an effective and safe means for intrathecal administration of morphine sulfate for treatment of chronic intractable pain."
04/01/2010 - " The Prometra pump provides an accurate, effective, and safe system for intrathecal administration of morphine sulfate for treatment of chronic intractable pain."
06/01/1994 - "Intraspinal infusion of morphine sulfate by use of an implanted, externally programmable pump is safe and effective in selected patients with intractable pain of nonmalignant origin."
04/01/2010 - "This trial evaluated the accuracy and efficacy of the new Prometra® Programmable Pump System for intrathecal administration of morphine sulfate to treat chronic intractable pain. "
|2.||Opioid Analgesics (Opioids)IBA
11/01/2000 - "This strategy could be very useful for the treatment of intractable pain that responds to opioids. "
12/01/2012 - "Epidural/subcutaneous reservoir therapy is often offered to relieve refractory pain, and to reduce the side effects of systemic administration of opioids, such as drowsiness, in homecare patients. "
07/01/2012 - "( good) 5. A) Long-acting opioids in high doses are recommended only in specific circumstances with severe intractable pain that is not amenable to short-acting or moderate doses of long-acting opioids, as there is no significant difference between long-acting and short-acting opioids for their effectiveness or adverse effects. "
07/01/2012 - "Intracerebroventricular opioids for intractable pain."
02/01/2012 - "Neuraxial (epidural and intrathecal) opioids for intractable pain."
|3.||ziconotide (Prialt)FDA Link
10/01/2006 - "Ziconotide, an intrathecal analgesic with orphan drug status, is a novel alternative for the management of chronic intractable pain. "
12/15/2014 - "There is also human validation data from ziconotide, the CaV2.2-selective peptidyl inhibitor used clinically to treat refractory pain. "
12/01/2012 - "Additionally, ziconotide, a selective peptide inhibitor of Ca(V)2.2 channels, is clinically used to treat refractory pain. "
08/01/2010 - "Ziconotide, a state-independent peptide inhibitor of Ca(v)2.2 channels, is efficacious in treating refractory pain but exhibits a narrow therapeutic window and must be administered intrathecally. "
07/01/2009 - "Although ziconotide is approved by the US Food and Drug Administration for monotherapy, it is sometimes used in combination with other intrathecal drugs for the management of intractable pain conditions in clinical practice. "
|4.||Bupivacaine (Bupivacaine Hydrochloride)FDA LinkGeneric
01/01/2014 - "Intrathecal bupivacaine delivery as a viable treatment of intractable pain is well documented. "
10/01/2011 - "In this retrospective study, 126 consecutive noncancer intractable pain patients were implanted with IDDS and initiated with an IT opioid (O) as a single medication or an IT opioid and bupivacaine (O + B). "
01/15/2006 - "Acute response to intracisternal bupivacaine in patients with refractory pain of the head and neck."
09/01/2000 - "Intrathecal (IT) administration of bupivacaine (BUP) for treatment of "refractory" pain has sometimes been associated with unacceptable side effects. "
02/01/1996 - "Continuous intracisternal infusion of bupivacaine may be a useful method in exceptional, well selected patients with refractory pain from the head and neck structures. "
|5.||Analgesics (Analgesic Drugs)IBA
12/01/2014 - "At the time of embolization, they experienced severe pain refractory to analgesics. "
10/01/2013 - "This review will focus on advances in topical analgesics, especially their role as an effective analgesic in nociceptive and neuropathic refractory pain states. "
01/01/2013 - "Thus, Cav3.2 T-channels are considered to serve as novel targets for development of drugs for treatment of intractable pain resistant to currently available analgesics. "
09/01/2012 - "A case is presented of a 69 year old male patient with a history of wrist fracture from over 50 years ago with pain refractory to analgesics and with joint destruction of the wrist in conventional radiology. "
07/01/2007 - "It is our objective to report our experience using intrathecal delivery of analgesics in a population of patients with refractory pain due to vertebral fractures. "
05/01/2008 - "Treatment with intravenous ketamine appeared to be effective in completely resolving intractable pain caused by severe refractory CRPS I. Future research on this treatment is needed."
02/01/2012 - "We conclude that in patients with severe refractory pain of multiple etiologies, subanesthetic ketamine infusions may improve VAS scores. "
09/01/2011 - "Our case series adds to the extant literature supporting the role of subanesthetic ketamine for refractory pain problems."
10/01/2008 - "We describe a case of opioid-refractory pain that responded to a low-dose IV infusion of ketamine in the inpatient setting. "
02/01/2002 - "There is a growing interest in low-dose ketamine as an analgesic agent in different intractable pain conditions. "
|7.||gabapentin (Neurontin)FDA LinkGeneric
02/01/2002 - "Gabapentin was effective in approximately 50% of pretreated patients with intractable pain. "
02/01/2002 - "It was therefore the aim to study gabapentin in patients suffering from intractable pain with respect to efficacy, predictive factors and side effects. "
02/01/2002 - "Retrospective analysis of the data sheet of pretreated patients suffering from intractable pain and treated with gabapentin as a third line drug at a university pain clinic. "
02/01/2002 - "[Gabapentin in the treatment of chronic intractable pain]."
06/01/2014 - "She was admitted to a tertiary pediatric hospital for intractable pain where PM&R diagnosed her with complex regional pain syndrome (CRPS) type 1, began gabapentin, and initiated an aggressive inpatient rehabilitation program. "
|8.||Methadone (Dolophine)FDA LinkGeneric
04/01/2008 - "Among the many patients served by methadone maintenance treatment programs (MMTPs) is a small population with severe, refractory pain that may be effectively managed using long-term opioid therapy. "
05/01/1985 - "Managing intractable pain with methadone (nursing grand rounds)."
01/01/1982 - "Methadone: an effective agent in managing intractable pain as a symptom of psychotic anger."
08/01/2013 - "Methadone is a commonly used opioid in hospice and palliative care for patients with refractory pain. "
03/01/2013 - "Methadone is one of the most important medications used for the treatment of refractory pain in the palliative care setting, and is usually initially prescribed by one of a limited number of physicians who have acquired authorization for its use. "
06/24/2015 - "In Switzerland, medical cannabinoids can be prescribed under compassionate use after special authorization in justified indications such as refractory pain. "
01/01/2008 - "Data show that cannabinoids are often effective in individuals with refractory pain receiving concomitant analgesic drugs. "
10/01/2005 - "Cannabinoids such as tetrahydrocannabinol offer a valuable add-on option for cancer patients with refractory pain, spasticity, nausea or appetite loss."
12/01/2014 - "A small number of high-quality clinical trials support the safety and efficacy of cannabinoids for treatment of spasticity of multiple sclerosis, pain refractory to opioids, glaucoma, nausea and vomiting. "
|10.||Narcotics (Narcotic Analgesics)IBA
11/01/1990 - "Continuous infusions of narcotics can be safely administered in the home setting, thus leading to an improved quality of life for patients with intractable pain. "
03/01/2014 - "His postoperative course was complicated by pain refractory to intravenous narcotics. "
02/01/1992 - "The IPTA brings Texas law more into conformity with federal law, which clearly states that narcotics have a proper place in the treatment of intractable pain even if the etiology is not established. "
01/01/1992 - "Treatment of intractable pain with parenteral, subarachnoid, or epidural narcotics is often unsatisfactory due to tolerance and other systemic complications that accompany increasing dosages of these drugs. "
08/01/1989 - "The other issues addressed include: Optimal use of narcotic analgesics and adjuvant drugs; and intractable pain syndromes. "
08/01/2009 - "For patients with severe and refractory pain in areas innervated by cranial and upper cervical nerves, cervical high spinal analgesia can provide safe and effective analgesia."
09/01/2004 - "Intraspinal analgesia can be helpful in some patients with intractable pain. "
11/01/2013 - "Good analgesia was achieved in 24/30 lesions (80%) that presented with intractable pain. "
02/01/2012 - "The intrathecal infusion of drugs to provide analgesia for terminally ill children with refractory pain is a rarely utilized but very effective technique. "
11/01/2009 - "The remaining patients suffer from intractable pain requiring intrathecal analgesia. "
10/01/2007 - "Total pancreatectomy followed by autologous islet cell autotransplantation appears to be a potential therapeutic approach but should be considered as the last option in patients with refractory pain who have failed conventional medical, endoscopic, and surgical options."
01/01/2015 - "In the last decade, total pancreatectomy with autologous islet cell transplantation has emerged as a promising treatment for the refractory pain of CP and is currently performed at approximately a dozen centers in the United States. "
09/01/2014 - "A sixty-five-year-old woman underwent total pancreatectomy for intractable pain without islet transplant, this patient was diagnosed as AP and MBL deficient from a blood test performed preoperatively. "
09/01/2012 - "One patient (disconnected duct syndrome) was considered a treatment failure as the stent migrated and the patient underwent distal pancreatectomy for refractory pain. "
06/01/2014 - "In pancreatitis, total pancreatectomy (TP) is an effective treatment for refractory pain. "
08/01/2005 - "This study confirms that vertebroplasty facilitates a rapid hospital discharge as well as long-term improvement in patients admitted for refractory pain. "
02/01/2011 - "Percutaneous vertebroplasty in painful osteoporotic vertebral collapse: a safe treatment option for intractable pain."
07/01/2009 - "This review aims to assess the effectiveness of percutaneous vertebroplasty as a treatment for the severe refractory pain associated with vertebral fracture, in a group of patients with fractures secondary to either osteoporotic or neoplastic disease. "
07/01/2006 - "Vertebroplasty is safe and efficacious; it is the treatment of choice for vertebral pain refractory to medication. "
02/01/2006 - "Percutaneous vertebroplasty in patients with intractable pain from osteoporotic or metastatic fractures: A prospective study using quality-of-life assessment."
09/01/1997 - "A computer model is used to calculate the optimum geometry of an epidural electrode, consisting of a longitudinal contact array, for spinal cord stimulation in the management of chronic, intractable pain. "
05/01/2005 - "This computer modelling study on motor cortex stimulation (MCS) introduced a motor cortex model, developed to calculate the imposed electrical potential field characteristics and the initial response of simple fibre models to stimulation of the precentral gyrus by an epidural electrode, as applied in the treatment of chronic, intractable pain. "
01/01/2003 - "The objectives of this study were to assess the effectiveness of cervical spinal cord stimulation in the management of intractable pain syndromes affecting the upper limb and face and to assess the reliability of a specific electrode system in this mobile environment. "
06/01/2006 - "The method of retrograde insertion of an electrode for spinal cord stimulation seems to be a good way to treat intractable pain of the area innervated by a single spinal nerve."
06/01/2005 - "We report the first patient with SUNCT in whom severe intractable pain (70 per day) was well controlled by electrode implant to and continuous stimulation of the posterior inferior hypothalamus. "
|5.||Palliative Care (Palliative Medicine)
01/01/2013 - "Lumbar paravertebral blockade as intractable pain management method in palliative care."
01/01/2011 - "Refractory pain, existential suffering, and palliative care: releasing an unbearable lightness of being."
01/01/2003 - "Terminal sedation: palliative care for intractable pain, post Glucksberg and Quill."
09/01/2000 - "If, nevertheless, intractable pain or ongoing disabling symptoms continue despite proper therapy, every doctor should feel himself obliged to consult an expert in palliative medicine, in order not to tolerate avoidable suffering of his patient."
04/01/2015 - "We describe here a patient who experienced intractable pain and unsuccessfully underwent cordotomy but responded to the interdisciplinary (IDT) palliative care approach in an acute palliative care unit (APCU). "