Pain (Aches)

An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
Also Known As:
Aches; Physical Suffering; Ache; Pain, Burning; Pain, Crushing; Pain, Migratory; Pain, Radiating; Pain, Splitting; Burning Pain; Burning Pains; Crushing Pain; Crushing Pains; Migratory Pain; Migratory Pains; Pains, Burning; Pains, Crushing; Pains, Migratory; Pains, Radiating; Pains, Splitting; Physical Sufferings; Radiating Pain; Radiating Pains; Splitting Pain; Splitting Pains; Sufferings, Physical; Suffering, Physical
Networked: 115883 relevant articles (14704 outcomes, 17380 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Neoplasms (Cancer)
2. Osteoarthritis
3. Inflammation
4. Neuralgia (Stump Neuralgia)
5. Migraine Disorders (Migraine)


1. Arendt-Nielsen, Lars: 171 articles (12/2015 - 01/2002)
2. Manchikanti, Laxmaiah: 165 articles (12/2015 - 01/2002)
3. Moore, R Andrew: 131 articles (01/2015 - 02/2002)
4. Derry, Sheena: 126 articles (01/2015 - 04/2004)
5. Mercadante, Sebastiano: 104 articles (02/2016 - 02/2002)
6. Kehlet, Henrik: 94 articles (12/2015 - 02/2002)
7. Jensen, Mark P: 93 articles (01/2016 - 01/2002)
8. Takahashi, Kazuhisa: 89 articles (12/2015 - 04/2002)
9. Porreca, Frank: 89 articles (11/2015 - 01/2002)
10. Svensson, Peter: 84 articles (08/2015 - 01/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pain:
1. Morphine (MS Contin)FDA LinkGeneric
2. Opioid Analgesics (Opioids)IBA
08/18/2015 - "However, close reading of the primary literature supports a different conclusion: opioids have been shown in randomized controlled trials (RCTs) to be highly effective in the treatment of chronic nonmalignant pain; long-term follow-up studies have shown that this effectiveness can be maintained; and effectiveness has been limited in many clinical trials by failure to take into account high variability in dose requirements, failure to adequately treat depression, and use of suboptimal outcome measures. "
05/01/2015 - "This study of patients with chronic spine pain was conducted to test the hypothesis that decreasing pain through interventional techniques coupled with cognitive motivational counseling can be highly effective in reducing chronic pain interference, reliance on prescription opioids, and enhancing overall function and quality of life. "
09/30/2014 - "The objectives of the article are to review the following: (1) the key initiating causes of the epidemic; (2) the evidence for safety and effectiveness of opioids for chronic pain; (3) federal and state policy responses; and (4) recommendations for neurologists in practice to increase use of best practices/universal precautions most likely to improve effective and safe use of opioids and to reduce the likelihood of severe adverse and overdose events. "
11/01/2012 - "Opioids are an extremely important part of medical practice, and for thousands of years, continued to provide relief from severe acute and chronic pain. "
01/01/2004 - "Opioid analgesics are highly effective for treating many forms of acute and chronic pain. "
3. Lidocaine (Xylocaine)FDA LinkGeneric
4. Analgesics (Analgesic Drugs)IBA
5. Acetaminophen (Paracetamol)FDA LinkGeneric
6. Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
7. Fentanyl (Sublimaze)FDA LinkGeneric
8. Bupivacaine (Bupivacaine Hydrochloride)FDA LinkGeneric
9. TramadolFDA LinkGeneric
10. Diclofenac (SR 38)FDA LinkGeneric

Therapies and Procedures

1. Analgesia
2. Injections
3. Arthroplasty
4. Aftercare (After-Treatment)
5. Drug Therapy (Chemotherapy)