|2.||Melanoma (Melanoma, Malignant)
|3.||Squamous Cell Carcinoma (Epidermoid Carcinoma)
|4.||Basal Cell Carcinoma (Rodent Ulcer)
|1.||Furue, Masutaka: 9 articles (10/2011 - 01/2007)|
|2.||Moroi, Yoichi: 8 articles (10/2011 - 01/2007)|
|3.||Takeuchi, Satoshi: 8 articles (10/2011 - 01/2007)|
|4.||Xie, Lining: 5 articles (10/2011 - 03/2010)|
|5.||Nakahara, Takeshi: 5 articles (10/2011 - 01/2007)|
|6.||Takahara, Masakazu: 5 articles (10/2011 - 03/2007)|
|7.||Hayashida, Sayaka: 5 articles (07/2011 - 06/2008)|
|8.||Uchi, Hiroshi: 5 articles (05/2010 - 01/2007)|
|9.||Tu, Ya-Ting: 4 articles (10/2011 - 06/2008)|
|10.||Tsuji, Gaku: 4 articles (10/2011 - 03/2010)|
|1.||imiquimod (Aldara)FDA LinkGeneric
09/21/2011 - "We present a case of a 59-year-old woman with primary extramammary Paget's disease of the vulva, in which a conservative approach to therapy was desired, and who underwent complete and stable remission with imiquimod cream. "
01/01/2012 - "[Extramammary Paget disease: successful therapy with imiquimod 5% cream]."
10/01/2012 - "Sustained remission of extramammary Paget disease following treatment with imiquimod 5% cream."
04/01/2010 - "Recently, topical Imiquimod has been shown as a safe and effective treatment option for extramammary Paget's disease. "
10/01/2014 - "We describe a case series that includes 10 patients with histopathologic diagnosis of extramammary Paget disease of the vulva, who were treated with 5% imiquimod cream. "
|2.||docetaxel (Taxotere)FDA Link
03/01/2012 - "Complete remission of advanced extramammary Paget's disease treated with docetaxel: a case report."
02/01/2006 - "Metastatic extramammary Paget's disease successfully controlled with tumour dormancy therapy using docetaxel."
01/01/2002 - "Docetaxel may be an effective drug for patients with advanced extramammary Paget's disease."
01/01/2002 - "Docetaxel induced durable response in advanced extramammary Paget's disease: a case report."
10/01/2011 - "Successful treatment of metastatic extramammary Paget's disease with S-1 and docetaxel combination chemotherapy."
01/01/2011 - "Following Cochrane guidelines, a comprehensive systematic review of all clinical studies and reports examining the use of PDT for mammary and extra-mammary Paget's disease was conducted. "
11/01/2009 - "Our aim was to determine the usefulness of fluorescence examination and photodynamic therapy (PDT) for the management of perianal extramammary Paget's disease. "
01/01/2009 - "Although photodynamic therapy (PDT) has been used for extramammary Paget's disease for some time, recurrence and residual tumour cells are common. "
02/01/2005 - "Photodynamic therapy (PDT), which employs a combination of a tumor-localizing photosensitizer and visible light, has been used in the treatment of extramammary Paget's disease (EMPD). "
09/01/2014 - "The combination treatment with 20% PDT and imiquimod acquired complete remission in treatment for recurrent and wide spread extramammary Paget disease in two patients."
03/01/2007 - "Retrospective chart review of 26,000 cases treated with MMS at the Geisinger Medical Center Department of Dermatology during a 16-year period with the following diagnoses: poorly differentiated squamous cell carcinoma (PDSCC), dermatofibrosarcoma protuberans (DFSP), microcystic adnexal carcinoma (MAC), extramammary Paget's disease (EMPD), Merkel cell carcinoma (MCC), and sebaceous carcinoma (SEB CA). "
12/01/1996 - "We describe our experience of this method in the management of squamous cell carcinomas (11), extramammary Paget's disease (two), microcystic adnexal cell carcinomas (two), dermatofibrosarcoma protuberans (two), and primary cutaneous neuroendocrine carcinoma (Merkel cell carcinoma) (one). "
08/01/2005 - "Its efficacy in treating BCC and SCC has led clinicians to explore the role of Mohs micrographic surgery in the management of less common cutaneous neoplasms, such as melanoma, Merkel cell carcinoma, dermatofibrosarcoma protuberans, extramammary Paget's disease, and microcystic adnexal carcinoma."
12/01/2008 - "In recent years, the application of immunostaining techniques has facilitated the successful removal of a number of common and less common cutaneous malignancies, including basal cell carcinoma, squamous cell carcinoma, malignant melanoma, dermatofibrosarcoma protuberans, microcystic adnexal carcinoma, sebaceous carcinoma, atypical fibroxanthoma, extramammary Paget's disease, and even sarcomas. "
08/01/1990 - "Between 1970 and 1984 in Rochester, Minnesota, rare skin cancers developed in 15 local residents: cutaneous T cell lymphoma (six subjects), dermatofibrosarcoma protuberans (four), adenocarcinoma of sweat glands (two), Merkel cell carcinoma (one), liposarcoma (one), and extramammary Paget's disease (one). "
|5.||Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA
10/01/1964 - "HISTOCHEMICAL STUDY OF MUCIN OCCURRING IN THE PAGET CELL OF EXTRAMAMMARY PAGET'S DISEASE."
09/01/2008 - "Mucin immunohistochemistry in the diagnosis and mapping of extramammary Paget's disease."
09/01/2004 - "Furthermore, the mucin core protein expression pattern, which was identical to that observed in extramammary Paget's disease, supported the above interpretation."
12/01/2001 - "Differential expression of mucin genes in mammary and extramammary Paget's disease."
07/01/1997 - "Cytokeratins, CEA, and mucin histochemistry in the diagnosis and characterization of extramammary Paget's disease."
12/01/1993 - "Paget cells in extramammary Paget disease revealed a similar cytokeratin expression to that in secretory cells of normal apocrine or eccrine glands. "
12/01/1993 - "Simple epithelial keratins were expressed in Paget cells in extramammary Paget disease, but no expression of differentiation-specific or noncornifying stratified squamous epithelial keratins was observed, regardless of the degree of invasion. "
12/01/1993 - "There was no significant difference in cytokeratin expression among these cases of extramammary Paget disease. "
02/01/1989 - "Immunohistochemical staining properties of keratin type intermediate filaments in mammary and extramammary Paget's disease."
01/01/1989 - "We studied the expression of CEA and keratin in two cases of extramammary Paget disease. "
|8.||Proteins (Proteins, Gene)IBA
08/01/2010 - "Immunohistochemical study of HER2 and TUBB3 proteins in extramammary Paget disease."
08/01/2008 - "The proteins p53, p63 and p73 are known to be overexpressed and to play important roles in the pathogenesis of many tumours, but the expression of p63 and p73 has not previously been investigated in extramammary Paget's disease (EMPD). "
12/01/2005 - "Here, we analyzed the correlation between activation of the HER2 signal pathways and clinicopathologic parameters of 36 extramammary Paget's disease samples from 34 Japanese patients, using immunohistochemical analyses for HER2, phosphorylated HER2, phosphorylated AKT, and phosphorylated ERK proteins. "
05/01/2002 - "Expression of mucin core proteins in extramammary Paget's disease."
01/01/1984 - "In an attempt to delineate the origin of the neoplastic cells in this disease, the immunoperoxidase localization of gross cystic disease fluid protein (GCDFP-15), a marker of apocrine epithelium, carcinoembryonic antigen (CEA), and keratin proteins, was determined for seven cases of extramammary Paget's disease (five vulvar, one anogenital, and one axillary). "
12/01/1984 - "Evaluation of carcinoembryonic antigen in extramammary Paget's disease."
02/01/2004 - "In addition, the carcinoembryonic antigen level, a useful tumor marker for extramammary Paget's disease, decreased remarkably. "
04/01/1985 - "There was positive intracytoplasmic staining for the carcinoembryonic antigen with the use of an immunoperoxidase stain, another similarity between this neoplasm and extramammary Paget's disease. "
04/01/1994 - "Rapid staining with carcinoembryonic antigen aids limited excision of extramammary Paget's disease treated by Mohs surgery."
01/01/1989 - "[Immunohistochemical study of the distribution of carcinoembryonic antigen and keratin in 2 cases of extramammary Paget disease]."
11/01/2010 - "Frequent expression of the breast differentiation antigen NY-BR-1 in mammary and extramammary Paget's disease."
12/27/2008 - "Interestingly, 7 out of 16 extramammary Paget's disease cases were immunopositive for these antigens. "
12/27/2008 - "The distribution of histo-blood group A type 1, 2 and 3 antigens was investigated using immunohistochemistry in normal human skin and extramammary Paget's disease (EMPD). "
12/27/2008 - "Expression of histo-blood group A type 1, 2 and 3 antigens in normal skin and extramammary Paget's disease."
04/01/1989 - "Some antigens, such as EMA and low molecular weight cytokeratins are consistently present in both diseases, whereas other antigens, identified by H.10.A and TW19 are found more frequently in cases of extramammary Paget's disease. "
05/01/2015 - "Extramammary Paget's disease of the perianal region treated successfully with radiotherapy."
01/01/1991 - "Radiotherapy: an effective treatment for extramammary Paget's disease."
09/01/2007 - "Several reports have suggested the efficacy of radiotherapy for treating extramammary Paget's disease (EMPD); however, these reports comprised only clinical observations, without in-depth histopathological observations. "
02/01/2015 - "External beam radiotherapy of extramammary Paget disease."
06/01/2014 - "Aggressive clinical course of extramammary Paget disease after radiotherapy."
|2.||Drug Therapy (Chemotherapy)
05/01/1999 - "We encountered a patient in whom extramammary Paget's disease had metastasized to the lymph nodes beyond the regional lymph nodes and systemic chemotherapy was partially effective. "
04/01/2015 - "Invasive cases of extramammary Paget's disease have a poor prognosis, owing to its rapid progression and resistance to irradiation and chemotherapy. "
02/01/2004 - "We evaluated chemotherapy in a patient with advanced extramammary Paget's disease of the male genitalia unassociated with an underlying malignancy. "
02/01/2004 - "An effective chemotherapy for advanced extramammary Paget's disease has not yet been established. "
08/01/1993 - "We reviewed systemic chemotherapy of extramammary Paget's disease in the literature, but only a few complete and partial responses were reported. "
|3.||Mohs Surgery (Mohs' Micrographic Surgery)
06/01/2012 - "In this study, we discuss our experience with extramammary Paget's disease, along with a novel approach to treatment by using a modification of peripheral Mohs micrographic surgery that incorporates histologic analysis of the central specimen's depth."
04/01/2013 - "Mohs micrographic surgery for extramammary Paget disease: a pooled analysis of individual patient data."
06/01/2012 - "Extramammary Paget's disease: a novel approach to treatment using a modification of peripheral Mohs micrographic surgery."
04/01/2009 - "[Extramammary paget disease: report of 2 cases treated by mohs micrographic surgery]."
01/01/2009 - "Comparison of Mohs micrographic surgery and wide excision for extramammary Paget's Disease: Korean experience."
|4.||Photochemotherapy (Photodynamic Therapy)
02/01/2012 - "Incomplete efficacy of 5-aminolevulinic acid (5 ALA) photodynamic therapy in the treatment of widespread extramammary Paget's disease."
07/01/2013 - "A prospective pilot study to evaluate combined topical photodynamic therapy and surgery for extramammary paget's disease."
07/01/2013 - "Photodynamic therapy with M-ALA as non surgical treatment option in patients with primary extramammary Paget's disease."
01/01/2013 - "Letter: Photodynamic therapy with methyl-aminolevulinate for the treatment of double extramammary Paget's disease."
02/01/2012 - "[Photodynamic therapy for the treatment of extramammary Paget's disease]."
01/01/2012 - "There are studies that have demonstrated the efficacy of imiquimod to treat Extramammary Paget's disease, but we found no mention in the literature of its use as neoadjuvant therapy previous to surgery excision. "
04/01/2008 - "Intralesional interferon alfa-2b as neoadjuvant treatment for perianal extramammary Paget's disease."