Mammary Paget's Disease

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26 relevant articles (1 outcomes, 4 trials/studies) found for this Disease

Description: An intraductal carcinoma of the breast extending to involve the nipple and areola, characterized clinically by eczema-like inflammatory skin changes and histologically by infiltration of the dermis by malignant cells (Paget's cells). (Dorland, 27th ed)

Also Known As:

Paget's Disease, Mammary; Mammary Paget Disease; Paget Disease of Breast; Paget Disease, Mammary; Disease, Mammary Paget; Disease, Mammary Paget's; Mammary Pagets Disease; Paget Disease, Breast; Pagets Disease, Breast; Pagets Disease, Mammary; Paget's Disease of Breast

Relationship Network

Disease Context: Research Results

Neoplasms: 415397

Neoplasms by Histologic Type: 1

Glandular and Epithelial Neoplasms: 252

Carcinoma: 92356

Adenocarcinoma: 27452

Noninfiltrating Intraductal Carcinoma: 1250

Mammary Paget's Disease: 26

Neoplasms, Ductal, Lobular, and Medullary

Noninfiltrating Intraductal Carcinoma: 1250

Mammary Paget's Disease: 26

Related Diseases

1.	Melanoma (Melanoma, Malignant)
2.	Carcinoma (Carcinomatosis)
3.	Extramammary Paget's Disease (Paget Disease, Extramammary)
4.	Breast Neoplasms (Breast Cancer)
5.	Neoplasms (Cancer)

Experts

1.	Yamazaki, Naoya: 1 article (10/2006)
2.	Machida, Hideki: 1 article (10/2006)
3.	Fujisawa, Yasuhiro: 1 article (10/2006)
4.	Yamamoto, Akifumi: 1 article (10/2006)
5.	D'Atri, Carmelo: 1 article (01/2006)
6.	Giovannini, Monica: 1 article (01/2006)
7.	Piubello, Quirino: 1 article (01/2006)
8.	Molino, Annamaria: 1 article (01/2006)
9.	Kondo, Yoshiyuki: 1 article (05/2002)
10.	Fujiwara, Sakuhei: 1 article (05/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Mammary Paget's Disease:

1.	p-Aminosalicylic Acid (PAS)FDA Link 08/01/1987 - "Cytoplasmic PAS-positive material was present in the tumor cells of 9/10 cases of vulvar Paget's disease, but was noted in only 1/9 cases of mammary Paget's disease. " 08/01/1987 - "The PAS and mucicarmine stains are helpful in differentiating anogenital Paget's disease from pagetoid melanoma, but are less useful in mammary Paget's disease. " 01/01/1992 - "Diastase-resistant PAS positivity was seen in six of 13 cases of mammary Paget's disease and eight of 13 cases using an alcian blue counterstain. " Order ALL the reference details at left...
2.	mucicarmineIBA 08/01/1987 - "In mammary Paget's disease, only 2/8 cases stained by the mucicarmine technique. " 08/01/1987 - "The PAS and mucicarmine stains are helpful in differentiating anogenital Paget's disease from pagetoid melanoma, but are less useful in mammary Paget's disease. " Order ALL the reference details at left...
3.	MucinsIBA 01/01/1992 - "We conclude that CAM 5.2 and 21N should be used in the investigation of mammary Paget's disease in preference to conventional mucin stains." 05/01/2002 - "We performed an immunohistochemical examination of the expression of gastric, intestinal, and mammary-type mucins in 25 lesions from patients with extramammary Paget's disease (ExMPD) and in 10 lesions from patients with mammary Paget's disease (MPD). " 08/01/1985 - "The conclusion derived from these observations is that the mucin in Paget cells of extramammary Paget's disease is different from that found in cells of mammary Paget's disease. " 08/01/1985 - "Based on the epidermal changes alone, Paget cells in 90% of specimens from lesions of extramammary Paget's disease had abundant mucin that stained well, whereas Paget cells in only 40% of specimens from mammary Paget's disease stained for mucin and faintly at that. " 01/01/1992 - "This study compares the diagnostic reliability of conventional mucin histochemistry and immunocytochemical techniques in distinguishing mammary Paget's disease from superficial spreading malignant melanoma and primary intraepidermal carcinoma. " Order ALL the reference details at left...
4.	AntigensIBA 02/01/1984 - "The same antigens were also found in the cells of intraductal or ductal adenocarcinomas of the breast associated with mammary Paget's disease, suggesting a common origin for the cells. " 01/01/1985 - "The immunoperoxidase technique was used to study the immunoreactivities of two murine monoclonal antibodies to carcinoma-associated antigens raised respectively against a human breast cancer line (MBr1) and an ovarian carcinoma (MOv2) and of a conventional anti-CEA serum in 20 cases of mammary Paget's disease of the nipple and in three cases of extramammary Paget's disease. " 04/01/1985 - "The authors have used the indirect immunoperoxidase technique to examine the presence and distribution of milk fat globule membrane antigens in 12 cases of mammary Paget's disease using two monoclonal antibodies, HMFG-1 and HMFG-2. " Order ALL the reference details at left...
5.	Monoclonal AntibodiesIBA 01/01/1985 - "The immunoperoxidase technique was used to study the immunoreactivities of two murine monoclonal antibodies to carcinoma-associated antigens raised respectively against a human breast cancer line (MBr1) and an ovarian carcinoma (MOv2) and of a conventional anti-CEA serum in 20 cases of mammary Paget's disease of the nipple and in three cases of extramammary Paget's disease. " 04/01/1985 - "The authors have used the indirect immunoperoxidase technique to examine the presence and distribution of milk fat globule membrane antigens in 12 cases of mammary Paget's disease using two monoclonal antibodies, HMFG-1 and HMFG-2. " 02/01/1999 - "We studied 22 cases of mammary Paget's disease and 22 cases of extramammary Paget's disease with and without an underlying malignancy for their reactivity with monoclonal antibodies to cytokeratin 7 (CK7) and cytokeratin 20 (CK20). " Order ALL the reference details at left...
6.	Hematoxylin (Haematoxylon)IBA 05/01/2009 - "Using standard hematoxylin and eosin-stained sections and routine immunohistochemical studies, we describe and characterize 7 cases of pigmented extramammary and mammary Paget disease. " 06/01/2007 - "Therefore, immunohistochemical staining should be performed in growing lesions with equivocal clinical and dermoscopic aspects that are characterized by abundant pagetoid infiltration in hematoxylin-eosin-stained sections to avoid overlooking pigmented mammary Paget disease." Order ALL the reference details at left...
7.	Eosine Yellowish-(YS) (Eosin)IBA 05/01/2009 - "Using standard hematoxylin and eosin-stained sections and routine immunohistochemical studies, we describe and characterize 7 cases of pigmented extramammary and mammary Paget disease. " 06/01/2007 - "Therefore, immunohistochemical staining should be performed in growing lesions with equivocal clinical and dermoscopic aspects that are characterized by abundant pagetoid infiltration in hematoxylin-eosin-stained sections to avoid overlooking pigmented mammary Paget disease." Order ALL the reference details at left...
8.	Cyclin D1IBA 07/01/2001 - "The objective of this study was to investigate the expression of c-erbB-2, p53, Ki-67, Cyclin D1, Bcl-2, estrogen receptors (ER), and progesterone receptors (PR) in mammary Paget disease. " Order ALL the reference details at left...
9.	Progesterone Receptors (Progesterone Receptor)IBA 07/01/2001 - "The objective of this study was to investigate the expression of c-erbB-2, p53, Ki-67, Cyclin D1, Bcl-2, estrogen receptors (ER), and progesterone receptors (PR) in mammary Paget disease. " Order ALL the reference details at left...
10.	Estrogen ReceptorsIBA 07/01/2001 - "The objective of this study was to investigate the expression of c-erbB-2, p53, Ki-67, Cyclin D1, Bcl-2, estrogen receptors (ER), and progesterone receptors (PR) in mammary Paget disease. " Order ALL the reference details at left...

Therapies and Procedures

1.	Simple Mastectomy 01/01/2006 - "CASE PRESENTATION: We here describe a case of Paget's disease occurring on the thoracic wall site of a previous simple mastectomy, and also briefly summarise the most important aspects leading to a diagnosis of mammary Paget's disease. " Order ALL the reference details at left...
2.	Modified Radical Mastectomy (Mastectomy, Modified) 06/01/1997 - "BACKGROUND: Management of patients with mammary Paget's disease is controversial; recent recommendations range from primary radiotherapy to modified radical mastectomy. " Order ALL the reference details at left...
3.	Mastectomy (Mammectomy) 01/01/2006 - "CONCLUSION: To the best of our knowledge, this is the first reported case of mammary Paget's disease occurring after mastectomy. " 01/01/2006 - "Mammary Paget's disease occurring after mastectomy." Order ALL the reference details at left...

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