Mammary Paget's Disease

An intraductal carcinoma of the breast extending to involve the nipple and areola, characterized clinically by eczema-like inflammatory skin changes and histologically by infiltration of the dermis by malignant cells (Paget's cells). (Dorland, 27th ed)
Also Known As:
Paget's Disease, Mammary; Mammary Paget Disease; Paget Disease of Breast; Paget Disease, Mammary; Paget's Disease of the Breast; Paget's Disease of the Nipple; Paget's Disease of the Nipple and Areola; Disease, Mammary Paget; Disease, Mammary Paget's; Mammary Pagets Disease; Paget Disease, Breast; Pagets Disease, Breast; Pagets Disease, Mammary; Paget's Disease of Breast
Networked: 73 relevant articles (3 outcomes, 9 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Melanoma (Melanoma, Malignant)
2. Carcinoma (Carcinomatosis)
3. Extramammary Paget Disease (Paget Disease, Extramammary)
4. Breast Neoplasms (Breast Cancer)
5. Noninfiltrating Intraductal Carcinoma (DCIS)


1. Crow, Julie C: 3 articles (01/2012 - 03/2002)
2. Ellis, Patricia E: 3 articles (01/2012 - 03/2002)
3. Perrett, Christopher W: 2 articles (01/2012 - 10/2008)
4. MacLean, Allan B: 2 articles (10/2008 - 03/2002)
5. Kalita, Dipti: 1 article (11/2015)
6. Nargotra, Namrata: 1 article (11/2015)
7. Napolitano, Larry: 1 article (05/2015)
8. Crowe, David: 1 article (05/2015)
9. Szpor, Joanna: 1 article (03/2015)
10. Dyduch, Grzegorz: 1 article (03/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Mammary Paget's Disease:
1. AntibodiesIBA
12/01/2005 - "As an in vivo model for highly motile tumor cells, Paget's disease of the nipple showed simultaneous EPIL and Her2 expression upon immunohistochemical examination using specific antibodies. "
12/01/1996 - "A comparative immunohistochemical study was performed on Paget's disease of the nipple (PDN), extramammary Paget's disease (EMPD) and cutaneous superficial spreading melanoma (SSM) using antibodies to S100, NK1-C3 and HMB45, cytokeratin (CAM 5.2) and c-erb B2 oncoprotein (21N). "
12/01/1993 - "Specimens of 35 cases of extramammary Paget disease (16 genital; 9 invasive carcinomas of genital; 6 axillary; 1 periumbilical; and 3 perianal), 4 cases of mammary Paget disease, 4 cases of breast carcinomas, and 6 cases of anal carcinomas of perianal spread from primary rectal adenocarcinomas were retrieved and stained by the avidin-biotin-complex method, using various kinds of monoclonal antikeratin antibodies. "
12/18/2008 - "Paraffin-embedded samples of Paget's disease of the breast (n=27) and of disease-free epidermis of the nipple (n=10) were investigated immunohistochemically for the presence of dendritic cells, in particular of Langerhans cells, using antibodies against S-100, CD1a, and HLA-DR, as well as novel reagents against Langerin/CD207, DC-LAMP/CD208 and p55 (Fascin), the latter two being specific for mature dendritic cells. "
02/01/1989 - "Utilizing three different anti-keratin antibodies and the avidin-biotin peroxidase complex system on sections of formalin-fixed paraffin-embedded tissues and on cryostat sections, immunohistochemical localization of keratin type intermediate filaments in mammary Paget's disease and extramammary Paget's disease was investigated. "
2. ParaffinIBA
3. Indicators and Reagents (Reagents)IBA
4. HLA-DR Antigens (HLA-DR)IBA
5. mucicarmineIBA
6. fascinIBA
7. Progesterone Receptors (Progesterone Receptor)IBA
8. MucinsIBA
9. Keratins (Keratin)IBA
10. AntigensIBA

Therapies and Procedures

1. Cryosurgery
2. Mastectomy (Mammectomy)
3. Radiotherapy
4. Radical Mastectomy
5. Segmental Mastectomy (Lumpectomy)