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p-Chloroamphetamine

Chlorinated analog of AMPHETAMINE. Potent neurotoxin that causes release and eventually depletion of serotonin in the CNS. It is used as a research tool.
Also Known As:
LY-121860; Ly-123362; Parachloroamphetamine; LY 121860; LY121860; Ly 123362; Ly123362; p Chloramphetamine; p Chloroamphetamine; para Chloroamphetamine; p-Chloramphetamine; para-Chloroamphetamine; Benzeneethanamine, 4-chloro-alpha-methyl-
Networked: 62 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Inoue, K: 2 articles (10/2001 - 08/2001)
2. Ohkura, M: 2 articles (10/2001 - 08/2001)
3. Sugimoto, Y: 2 articles (10/2001 - 08/2001)
4. Yamada, J: 2 articles (10/2001 - 08/2001)
5. Hsieh, M T: 2 articles (01/2001 - 01/2000)
6. Wu, C R: 2 articles (01/2001 - 01/2000)
7. Kostrzewa, John P: 1 article (03/2020)
8. Kostrzewa, Richard M: 1 article (03/2020)
9. Ahn, Gook Jun: 1 article (04/2013)
10. Kang, Kyung Koo: 1 article (04/2013)

Related Diseases

1. Premature Ejaculation
2. Hyperthermia
3. Chronic Pain
4. Shock
5. Tremor (Tremors)
11/01/1977 - "A single dose of p-chloroamphetamine, 10 mg per kilogram, produced postural abnormalities, tremor, myoclonus, and autonomic signs in rats 5 minutes after intraperitoneal injection. "
07/01/1986 - "The behavioural responses to 5-MeODMT (with and without the monoamine oxidase inhibitor pargyline) or to p-chloroamphetamine were not significantly different to those of males except for tremor after p-chloroamphetamine which was more marked in the females. "
03/01/1976 - "Administration of p-chloroamphetamine (PCA) (2.5-10.0 mg/kg) or fenfluramine (FF) (5.0-15.0 mg/kg) to rats induces a behavioral syndrome--consisting of tremor, rigidity, Straub tail, hindlimb abduction, lateral head weaving and reciprocal forepaw treading--which is a reflection of the activity of central serotonin-mediated synapses. "
03/25/1985 - "Some responses to the 5-HT releaser p-chloroamphetamine (PCA) (4 and 10 mg/kg, i.p.) and the 5-HT agonist 5-methoxy-N,N-dimethyltryptamine (5-MEODMT) (5 mg/kg, i.p.) (forepaw treading and tremor) were enhanced after 7 days immobilization but others (limb abduction and headweaving) were not. "
01/01/1991 - "Idazoxan pre-treatment, in rats, enhanced forepaw treading, head weaving and tremor induced by the 5-HT agonist 5-methoxy-N,N dimethyltryptamine (5-MeODMT), increased head twitches (but decreased hindlimb abduction) induced by the 5-HT releaser p- chloroamphetamine (pCA), but did not clearly alter head twitches induced by the 5-HT precursor L-5-hydroxytryptophan in mice. "

Related Drugs and Biologics

1. DA 8031
2. Serotonin (5 Hydroxytryptamine)
3. Neurotoxins
4. Nerve Growth Factor (NGF)
5. Brain-Derived Neurotrophic Factor (BDNF)
6. Nerve Growth Factors (Neurotrophins)
7. Fenfluramine
8. Scopolamine (Hyoscine)
9. Fenclonine (p-Chlorophenylalanine)
10. Amphetamine (Amfetamine)

Related Therapies and Procedures

1. Intraperitoneal Injections
2. Spinal Injections
3. Analgesia