p-Aminohippuric Acid (p-Aminohippurate)

The glycine amide of 4-aminobenzoic acid. Its sodium salt is used as a diagnostic aid to measure effective renal plasma flow (ERPF) and excretory capacity.

Also Known As:

p-Aminohippurate; Aminohippurate Sodium; Aminohippuric Acid; Nephrotest; Sodium Para-Aminohippurate; 4 Aminohippuric Acid; Para-Aminohippurate, Sodium; Sodium Para Aminohippurate; Sodium, Aminohippurate; p Aminohippurate; p Aminohippuric Acid; para Aminohippuric Acid; 4-Aminohippuric Acid; para-Aminohippuric Acid; Glycine, N-(4-aminobenzoyl)-

Networked: 141 relevant articles (19 outcomes, 16 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Flamant, Martin: 5 articles (01/2020 - 09/2017)
2.	Haymann, Jean-Philippe: 5 articles (01/2020 - 09/2017)
3.	Houillier, Pascal: 5 articles (01/2020 - 09/2017)
4.	Metzger, Marie: 5 articles (01/2020 - 09/2017)
5.	Boffa, Jean-Jacques: 4 articles (10/2019 - 09/2017)
6.	Stengel, Bénédicte: 4 articles (10/2019 - 09/2017)
7.	Thervet, Eric: 4 articles (10/2019 - 09/2017)
8.	Vrtovsnik, François: 4 articles (10/2019 - 09/2017)
9.	Bjornstad, Petter: 3 articles (05/2022 - 01/2020)
10.	Schmieder, Roland E: 3 articles (04/2010 - 01/2002)

Related Diseases

1.	Body Weight (Weight, Body) 01/01/1978 - "Tubular secretory capacity has been investigated in the kidney of marine fishes Scorpaena porcus, Spicara smaris, frog Rana ridibunda and albino rat by determination of maximal transport of p-aminohippurate--TmPAH, Following values of Tmax expressed in mg/hour per 100 g of body weight were obtained: 0.73 +/- 0.17 for S. " 10/01/1988 - "A pressor response was observed in the latter at a dose of 10 pmol h-1 (100 g body weight)-1. 3. Pressor doses of vasopressin of 100 pmol h-1 (100 g body weight)-1 and less did not significantly alter the clearance of p-aminohippurate (PAH) in either conscious or anaesthetized rats. " 01/01/2020 - "At baseline, twenty-four piglets (12 treatment/12 control; 7 weeks old, all ♂) received the marker drugs iohexol (64.7 mg/kg body weight (BW)) and para-aminohippuric acid (10 mg/kg BW) to quantify glomerular filtration rate and effective renal plasma flow, respectively. " 02/01/1988 - "Para-aminohippuric acid (PAHA, 0.1 mg/min/kg of body weight) was infused IV into 2 mares, followed by concurrent IV infusion of PAHA and probenecid (0.075, 0.15, 0.25, or 0.35 mg of probenecid/min/kg). " 03/01/2010 - "Barrows (n 6; aged 35 d; weight 8.6 kg), implanted with arterial, portal, mesenteric and gastric catheters, were fed a diet containing dl-methionine (dl-MET) or dl-HMTB once hourly and infused intramesenterically with 1 % p-aminohippurate and intragastrically with [1-13C]methionine at 7.0 mumol/kg body weight per h. "
2.	Renal Insufficiency (Renal Failure) 11/01/1975 - "In the subject with asymptomatic renal failure, chelation therapy increased the glomerular filtration rate, p-aminohippurate (PAH) extraction, the maximal PAH secretion rate (TmPAH) and improved proximal tubule ultrastructure, despite decreased renal plasma flow. " 12/01/1993 - "We measured glomerular filtration rate and p-aminohippurate clearance before and after 4 weeks of treatment with CGS 12970 in 13 patients with renal allografts who had been treated with CsA for a mean 6.3 months and had mild renal insufficiency. " 03/01/1989 - "Glomerular Filtration Rate (GFR) and Renal Plasma Flow (RPF) were measured respectively, Polyfructosan and Para-aminohippuric acid clearances, in 13 patients with different degrees of renal insufficiency. " 10/01/1982 - "In fifty-seven patients with liver cirrhosis without overt renal failure endotoxin plasma level (Limulus Lysate test), mean renal blood flow (MRBF) (133Xe washout technique), and effective renal plasma flow (ERPF) (p-aminohippurate clearance) were determined. " 04/01/1989 - "The work included here examines the effects of limited renal failure on two separate functions of the nephron: glomerular filtration, as measured by inulin clearance and proximal tubular organic anion secretory function, as measured by p-aminohippuric acid (PAH) clearance. "
3.	Hypertension (High Blood Pressure) 10/02/2018 - "Extracellular Fluid Volume Is an Independent Determinant of Uncontrolled and Resistant Hypertension in Chronic Kidney Disease: A NephroTest Cohort Study." 05/09/1991 - "We compared renal hemodynamics, measured in terms of the clearance of para-aminohippuric acid and inulin, and the characteristics of the renin-angiotensin-aldosterone system in three groups of normotensive subjects at different degrees of risk for hypertension: 41 subjects with two normotensive parents, 52 with one normotensive and one hypertensive parent, and 61 with two hypertensive parents. " 01/01/2002 - "Normotensive young men (25 +/- 2 years) with positive family history (PFH) (n = 28) and negative family history (NFH) (n = 60) of arterial hypertension were investigated to study aldosterone response, and systemic and renal haemodynamic changes (p-aminohippurate- and inulin-clearance) to Ang II infusion (0.5 and 3.0 ng/min per kg). " 09/01/1997 - "To investigate changes in systemic and regional hemodynamics during the development of human hypertension, we simultaneously measured cardiac index (CI) by the indocyanine green (ICG) dye dilution method, hepatosplanchnic blood flow (HBF) by the ICG clearance method using a two-compartment model, and renal blood flow (RBF) by the p-aminohippurate clearance method in patients with borderline and essential hypertension. " 01/01/1982 - "Inulin clearance was measured in 624 patients with gout, and para-aminohippuric acid (PAH) clearance in 359; Group I consisted of 397 patients with uncomplicated gout; Group II, 191 patients with hypertension and/or ischemic heart disease; and Group III, 36 patients with chronic renal disease. "
4.	Chronic Kidney Failure (Chronic Renal Failure) 08/01/1995 - "We have measured clearance of inulin and para-aminohippuric acid in 18 children with chronic renal failure (CRF) during their 1st year of rhGH treatment to look at the immediate (first 3 h), short-term (1 week) and long-term (1 year) effects of treatment. " 10/06/2017 - "Correction to: Association of plasma potassium with mortality and end-stage kidney disease in patients with chronic kidney disease under nephrologist care - The NephroTest study." 09/12/2017 - "Association of plasma potassium with mortality and end-stage kidney disease in patients with chronic kidney disease under nephrologist care - The NephroTest study." 10/01/1991 - "Effects of tenoxicam on renal function and the disposition of inulin and p-aminohippurate in healthy volunteers and patients with chronic renal failure." 01/01/1981 - "3-alpha-Phenyl-propyl-5-beta-diethylaminoethyl-1,2,3-oxadiazole (proxazole), a spasmolytic papaverine-like agent, was i.v. administered to 13 patients with chronic renal failure (mean creatinine clearance 46.4 ml/min/1.73 m2), but did not improve renal plasma flow (p-aminohippurate clearance) or glomerular filtration rate (inulin clearance), nor did this agent prevent or modify nor-adrenaline induced renal ischemia. "
5.	Essential Hypertension 03/01/1947 - "Renal extraction of p-aminohippurate in normal subjects and in essential hypertension and chronic diffuse glomerulonephritis." 07/01/1982 - "To test these hypotheses, techniques for the clearance of inulin (Cin) and p-aminohippurate (Cpah) were used to assess renal function and hemodynamic measurements in patients with mild and moderate normal-renin and low-renin essential hypertension and in age-matched normotensive subjects. " 01/01/1988 - "We have therefore begun a study in hypertensive sibships (two sibs in a family with essential hypertension under the age of 60 years), assessing the basal renal blood flow [p = aminohippurate (PAH) clearance] and the response of renal blood flow to infused angiotensin II (AII) (3 ng/kg/min) on a 200-mEq sodium intake. " 09/01/1997 - "To investigate changes in systemic and regional hemodynamics during the development of human hypertension, we simultaneously measured cardiac index (CI) by the indocyanine green (ICG) dye dilution method, hepatosplanchnic blood flow (HBF) by the ICG clearance method using a two-compartment model, and renal blood flow (RBF) by the p-aminohippurate clearance method in patients with borderline and essential hypertension. " 12/01/1995 - "To determine the effects of circadian variation in arterial pressure on early hypertensive target organ disease, we examined systemic hemodynamics (cardiac output by indocyanine green dye dilution), renal hemodynamics (renal plasma flow by iodine-131 para-aminohippuric acid clearance), left ventricular structure and function (2D-guided M-mode echocardiogram), and 24-h ambulatory blood pressure in 20 women and 46 men with untreated essential hypertension. "

Related Drugs and Biologics

1.	Inulin
2.	Creatinine
3.	Albumins
4.	Proteins (Proteins, Gene)
5.	Potassium
6.	Sodium
7.	Nitric Oxide (Nitrogen Monoxide)
8.	Urea (Carbamide)
9.	Tetraethylammonium (Tetraethylammonium Bromide)
10.	Tea

Related Therapies and Procedures

1.	Lasers (Laser)
2.	Intravenous Administration
3.	Chelation Therapy (Therapy, Chelation)
4.	Surgical Instruments (Clip)
5.	Catheters