|1.||Go, Vay Liang: 2 articles (01/2013 - 02/2010)|
|2.||Yen, Yun: 2 articles (01/2013 - 02/2010)|
|3.||Lee, Wai-Nang Paul: 2 articles (01/2013 - 02/2010)|
|4.||Recker, Robert: 2 articles (01/2013 - 02/2010)|
|5.||Xiao, Gary Guishan: 2 articles (01/2013 - 02/2010)|
|6.||Wang, Qi: 2 articles (01/2013 - 02/2010)|
|7.||Zhao, Yingchun: 2 articles (01/2013 - 02/2010)|
|8.||Hoffmann, Peter: 1 article (06/2015)|
|9.||Cheruvu, Sowmya: 1 article (06/2015)|
|10.||Tan, Izza A: 1 article (06/2015)|
01/01/2014 - "However, thiamine deficiency itself inhibited the proliferation to a greater degree than did oxythiamine. "
01/01/2002 - "The experiments reported in this series of studies demonstrate that thiamine deficiency, induced pharmacologically by oxythiamine (OT) coupled with the acute administration of ethanol can adversely affect memory processing in the young chick. "
08/01/1990 - "Radiometric assays revealed that thiamine deficiency in rats to whom hydroxythiamine was administered in variable doses, is concomitant with activation of gluconeogenesis from pyruvate in liver tissue. "
07/01/1990 - "Thiamine-deficiency in animals induced by everyday subcutaneous administration of oxythiamine in a dose of 4, 40 and 100 mg/kg of weight for 10 days results in a decrease of the total activity of pyruvate kinase in the liver tissue and does not affect the mentioned index in the kidney and heart tissues. "
08/01/1985 - "Thiamine deficiency in rats induced by oxythiamine is accompanied by an increase in the free NADP+/NADPH ratio in liver tissue, which results in multifold stimulation of the metabolite flux in the oxidation branch of the pentose cycle. "
|2.||Memory Disorders (Memory Loss)
10/01/1997 - "This series of studies revealed that a 2.5-mg dose of oxythiamine administered over 2 days yielded memory deficits from 10 min following passive avoidance learning. "
10/01/1997 - "The combination of alcohol and oxythiamine also slowed the righting reflex, but higher doses of thiamine also were unable to ameliorate the memory deficit caused by a combination of oxythiamine and alcohol; however, the slowing of righting reflex was reversed. "
10/01/1997 - "A combination of oxythiamine and peripheral alcohol administration also resulted in memory deficits appearing from 10 min after training; however, in contrast to the effect of thiamine deficiency alone, the deficits induced by thiamine deficiency in association with acute administration of alcohol could not be reversed by thiamine resupplementation. "
|3.||Breast Neoplasms (Breast Cancer)
08/01/2014 - "This study uses two-photon fluorescence lifetime imaging microscopy (FLIM) to investigate metabolic changes in MCF10A premalignant breast cancer cells treated with a range of glycolysis inhibitors: namely, 2 deoxy-D-glucose, oxythiamine, lonidamine, and 4-(chloromethyl) benzoyl chloride, as well as the mitochondrial membrane uncoupling agent carbonyl cyanide m-chlorophenylhydrazone. "
08/01/2009 - "TKTL 1 was highest expressed in cell lines derived from more invasive tumors but the expression level was not strongly correlated to proliferation rate, to GLUT-1 expression or to the response to oxythiamine. "
07/30/1999 - "Experimentally, a dramatic decrease in tumor cell proliferation after the administration of the TK inhibitor oxythiamine (OT) was observed in several in vitro and in vivo tumor models. "
06/01/1998 - "Oxythiamine produced strong apoptosis in in-vitro hosted tumor cells. "
09/01/1992 - "[The effect of oxythiamine on tumor growth and certain biochemical and genetic characteristics of normal and tumor cells]."
01/01/1986 - "[Comparative evaluation of the action of oxythiamine and its derivatives on animals with Erhlich's ascitic cancer]."
|5.||Avitaminosis (Vitamin Deficiency)
03/01/1985 - "One of the forms does not react to development of avitaminosis in animals caused by oxythiamine in different doses. "
01/01/1966 - "[Some protein metabolism indicators in acute avitaminosis induced one day after administration of a large dose of oxythiamine]."
07/01/1964 - "[THE FORMATION OF SEDOHEPTULOSE-7-PHOSPHATE IN PIGEON TISSUES IN ACUTE B1 AVITAMINOSIS CAUSED BY OXYTHIAMINE]."
05/01/1989 - "Acute oxythiamine B1 avitaminosis (single subcutaneous administration of oxythiamine at a dose of 400 mg/kg) led to a decrease in the label incorporation into spleen DNA of immunized rats by 70% (p less than 0.01) as compared with control immunized animals, while incorporation of 14C-thymidine was unaltered in intact rats. "
11/01/1983 - "[Phospholipids in the liver and brain of animals in acute oxythiamine-induced avitaminosis B1]."
|1.||Ethanol (Ethyl Alcohol)
|2.||Deoxyglucose (2 Deoxy D glucose)
|8.||Pyruvic Acid (Pyruvate)
|1.||Heterologous Transplantation (Xenotransplantation)