Oxygenators

Devices which mechanically oxygenate venous blood extracorporeally. They are used in combination with one or more pumps for maintaining circulation during open heart surgery and for assisting the circulation in patients seriously ill with some cardiac and pulmonary disorders. (UMDNS, 1999)

Also Known As:

Networked: 562 relevant articles (18 outcomes, 43 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1.	Philipp, Alois: 8 articles (08/2022 - 07/2013)
2.	Lehle, Karla: 7 articles (08/2022 - 07/2013)
3.	Schmitz-Rode, Thomas: 7 articles (01/2022 - 11/2010)
4.	Steinseifer, Ulrich: 7 articles (01/2022 - 11/2010)
5.	Lubnow, Matthias: 6 articles (08/2022 - 07/2013)
6.	Müller, Thomas: 6 articles (08/2022 - 06/2014)
7.	Arens, Jutta: 5 articles (01/2022 - 11/2010)
8.	Schmid, Christof: 5 articles (01/2018 - 07/2013)
9.	Butt, Warwick: 4 articles (01/2022 - 05/2014)
10.	Griffith, Bartley P: 4 articles (01/2021 - 10/2009)

Related Diseases

1.	Wounds and Injuries (Trauma) 02/01/2002 - "These data suggest that this newly improved oxygenator has superior efficiency, less blood trauma, and may be suitable for not only long-term ECMO but also pediatric CPB usage." 02/01/1982 - "This case illustrates the technical progress which has been made in CPB: reduction of blood cell trauma in the bypass circuits, improved oxygenation reducing the disturbances of tissue perfusion usually associated with bubble oxygenators. " 09/01/2000 - "This study compares the gas transfer capacity, the blood trauma, and the blood path resistance of the hollow-fiber membrane oxygenator Dideco D 903 with a surface area of 1.7 m2 (oxygenator 1.7) versus a prototype built on the same principles but with a surface area of 2 m2 (oxygenator 2). " 07/01/1984 - "These studies also demonstrated far less trauma to platelets with the use of a membrane rather than a bubble oxygenator. " 03/01/2017 - "Geometrical features of a typical commercial blood oxygenator is adopted and results in general show that a balance in pressure drop, shear stress, and mass transfer is required to avoid potential blood trauma or clotting formation. "
2.	Hypoxia (Hypoxemia) 11/01/2016 - "The results demonstrated that the PediPL (miniature integrated pump-oxygenator) has the potential to provide respiratory support as a novel treatment for both hypoxia and hypercarbia. " 09/01/2020 - "For repeated cannulation, the most common cause was hypoxia (64%, 9 patients), with 6 of these patients requiring a right ventricular assist device plus oxygenator. " 06/01/2020 - "Last, in cases of venoarterial extracorporeal membrane oxygenation, to measure gas variation and exclude differential hypoxia, blood samples of the native and extracorporeal (post-oxygenator) circulations are recommended." 09/01/2018 - "During CPB, lung ventilation is halted and oxygenation is performed by the CPB oxygenator and perfusion team This recurrent transfer throughout the procedure introduces the rare but serious possibility of a "never event", resulting in the patient's lungs not being ventilated upon stopping the CPB and potentially leading to catastrophic hypoxemia. " 09/01/2016 - "Second, if hypoxemia persists, algorithm considers multiple reasons for inadequate oxygenation, namely: (1) excessive recirculation, (2) excessive cardiac output (decrease of ratio pump flow/cardiac output), (3) decrease in SvO2 (oxygen saturation in mixed venous blood), (4) malfunction of oxygenator, and (5) deterioration of residual lung function. "
3.	Hypothermia 10/01/1994 - "In the 1950s, Sealy and his co-workers developed an improved technique for inducing cardiac and total body hypothermia using a pump oxygenator and heat exchanger. " 09/01/1960 - "Experience with perfusion hypothermia using an improved rotating disc oxygenator." 06/01/1981 - "In this study, the Shiley 100 A oxygenator was found to be the most suitable for cases requiring mild hypothermia and was generally considered to be the oxygenator of choice." 05/01/1961 - "Survival and physiologic studies with profound hypothermia (0 degree to 8 degrees C.) and a pump-oxygenator in dogs." 10/01/1959 - "Experimental studies on the production of deep hypothermia by means of a pump oxygenator and heat exchanger with a note on the clinical application."
4.	Hypoventilation 11/01/1994 - "This open clinical study was aimed at testing the hypothesis that an intravascular oxygenator (IVOX) may help to perform permissive hypoventilation in 10 patients with severe ARDS. " 07/01/1984 - "Experiments on 11 dogs under hypoventilation hypoxia (a decrease in the respiratory minute volume by 40-50%) were made to study the efficacy of membrane oxygenation using a membrane Sever-OMP oxygenator of the blood under the conditions of minor perfusion (14-17% of the minute volume of circulation). "
5.	Hemolysis 09/01/2007 - "The combination of a Rotaflow centrifugal pump and Lilliput 2 ECMO oxygenator in pediatric ECMO circuits improved durability and reduced circuit-induced hemolysis. " 04/01/2010 - "In this study, the hypothesis was tested that a low-resistant, high-compliant oxygenator provides better pulse conductance and less hemolysis than a high-resistant, low-compliant oxygenator during pulsatile cardiopulmonary bypass. " 01/01/2008 - "This study focuses on how the reduction of surface area and prime volume affects the essential function of the oxygenator in terms of oxygenation efficiency, heat transference, membrane pressure drops, haemolysis and safety. " 01/01/2006 - "In this study, effects of poly(2-metoxyethyl acrylate) (PMEA)-coated oxygenators on haemolysis was investigated. " 10/20/2023 - "Both the computational and experimental data showed that the pressure drop through the PPL's oxygenator is significantly low, even at a flow rate of more than 3.5 L/min. The PPL showed better hemolysis performance than a commercial ECMO circuit consisting of the Quadrox-iD pediatric oxygenator and the Rotaflow pump at a 3.5 L/min flow rate and 250 mm Hg afterload pressure. "

Related Drugs and Biologics

1.	Oxygen (Dioxygen)
2.	Nitric Oxide (Nitrogen Monoxide)
3.	Vincamine
4.	Vasodilator Agents (Vasodilators)
5.	Papaverine
6.	Aprotinin (Trasylol)
7.	Heparin (Liquaemin)
8.	Carbon Dioxide
9.	Silicones
10.	Solutions

Related Therapies and Procedures

1.	Cardiopulmonary Bypass (Heart-Lung Bypass)
2.	Therapeutics
3.	Membrane Oxygenators (Membrane Oxygenator)
4.	Coronary Artery Bypass (Coronary Artery Bypass Surgery)
5.	Extracorporeal Membrane Oxygenation