Oxepins (Oxepin)

Compounds based on a 7-membered heterocyclic ring including an oxygen. They can be considered a medium ring ether. A natural source is the MONTANOA plant genus. Some dibenzo-dioxepins, called depsidones, are found in GARCINIA plants.

Also Known As:

Networked: 16 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Andreeva, Olga E: 1 article (09/2019)
2.	Khripach, Vladimir A: 1 article (09/2019)
3.	Mekhtiev, Arif R: 1 article (09/2019)
4.	Savochka, Aleh P: 1 article (09/2019)
5.	Scherbakov, Alexander M: 1 article (09/2019)
6.	Shchegolev, Yuri Yu: 1 article (09/2019)
7.	Shcherbinin, Dmitrii S: 1 article (09/2019)
8.	Zhabinskii, Vladimir N: 1 article (09/2019)
9.	Debski, Janusz: 1 article (01/2018)
10.	Garbicz, Damian: 1 article (01/2018)

Related Diseases

1.	Osteoarthritis 01/01/1978 - "Clinical evaluation in phase II of 6,11-dihydro-11-oxodibenz[b,e]oxepin-3-acetic acid (oxepinac) has been made in a single-blind trial in the treatment of osteoarthritis, 135 patients with mainly gonitis. "
2.	Neoplasms (Cancer) 12/22/2017 - "Cytotoxicity tests of the isolated compounds showed that 6-hydroxy-3-methyl-8-phenylethylbenzo[b]oxepin-5-one (8) showed activity against the human cancer cell lines MCF-7, PC-3, and SMMC-7721, with IC50 values of 3.86, 6.60, and 3.58 μM, respectively, and induced MCF-7 cell death through a mitochondria-mediated apoptosis pathway." 01/01/2018 - "Evaluation of Anti-cancer Activity of Stilbene and Methoxydibenzo[b,f] oxepin Derivatives." 03/01/2006 - "Bioassay-guided (P388 lymphocytic leukemia cell line) separation of extracts prepared from the leaves, stems, and pods of Bauhinia purpurea, and, in parallel, its roots, led to the isolation of four new dibenz[b,f]oxepins (2a, 3-5) named bauhiniastatins 1-4, as well as the known and related pacharin (1) as cancer cell growth inhibitors. " 06/15/2012 - "Previously we reported the identification of a new oxepin-containing diketopiperazine-type marine fungal metabolite, named protuboxepin A which showed antiproliferative activity in several cancer cell lines. "
3.	Edema (Dropsy) 07/01/1978 - "6,11-Dhydro-11-oxodibenz[b,e]oxepins and some related compounds have been synthesized and evaluated for antiinflammatory effect according to the carrageenan paw edema method in rats. " 11/01/1977 - "Omega-(6,11-Dihydro-11-oxodibenz[b,e]oxepin-2-yl)butyric, -hexanoic, and -octanoic acids were evaluated in the carrageenan paw edema assay. " 01/01/1977 - "A series of 6,11-dihydrodibenz[b,e]oxepin-2-acetic acids has been evaluated for both antiinflammatory and analgetic activity in the carrageenan paw edema and phenylquinone writhing assays. "
4.	Ulcer 01/01/1984 - "The anti-ulcer and antisecretory properties of 3-(dibenz[b,e] oxepin - 11(6H)-ylidene)-N,N- dimethylpropylamine hydrochloride (doxepin) were investigated in a series of acute experiments in rats with gastric and duodenal ulcer. "
5.	Rhinitis 09/01/1995 - "Effect of (Z)-11-[3-(dimethylamino) propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid hydrochloride on experimental allergic conjunctivitis and rhinitis in rats and guinea pigs."

Related Drugs and Biologics

1.	Acetic Acid (Vinegar)
2.	oxepinac
3.	Carrageenan
4.	Brassinosteroids
5.	Antipyretics
6.	Diketopiperazines
7.	Anti-Allergic Agents (Antiallergic Agents)
8.	Stilbenes
9.	Estrogen Receptors
10.	Pyrogens